Outline Uses
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1-Adamantanol

Outline Uses
Product Name
1-Adamantanol
CAS No.
768-95-6
Chemical Name
1-Adamantanol
Synonyms
1-AD-OH;1-ADA-OH;1-Adamantol;ADAMANTANOL;damantol-(1);1-Adamatanol;AKOS BC-0650;1-Admantanol;1-Adamantano;1-ADAMANTANOL
CBNumber
CB2135047
Molecular Formula
C10H16O
Formula Weight
152.23
MOL File
768-95-6.mol
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1-Adamantanol Property

Melting point:
247 °C (subl.) (lit.)
Boiling point:
214.73°C (rough estimate)
Density 
0.8544 (rough estimate)
refractive index 
1.4880 (estimate)
Flash point:
240°C
storage temp. 
Sealed in dry,Room Temperature
pka
15.38±0.20(Predicted)
form 
Crystalline Powder or Needles
color 
White to off-white
Water Solubility 
Soluble in ethanol , methanol, and diethyl ether. Partly miscible in water.
Sublimation 
240 ºC
BRN 
1903952
InChIKey
VLLNJDMHDJRNFK-UHFFFAOYSA-N
CAS DataBase Reference
768-95-6(CAS DataBase Reference)
NIST Chemistry Reference
1-Adamantanol(768-95-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
RTECS 
AU4980000
Hazard Note 
Irritant
HS Code 
29061900
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
130346
Product name
1-Adamantanol
Purity
ReagentPlus , 99%
Packaging
5g
Price
$27
Updated
2021/03/22
Sigma-Aldrich
Product number
130346
Product name
1-Adamantanol
Purity
ReagentPlus , 99%
Packaging
25g
Price
$69.5
Updated
2021/03/22
TCI Chemical
Product number
A0939
Product name
1-Adamantanol
Purity
>98.0%(GC)
Packaging
25g
Price
$83
Updated
2021/03/22
TCI Chemical
Product number
A0939
Product name
1-Adamantanol
Purity
>98.0%(GC)
Packaging
250g
Price
$416
Updated
2021/03/22
Alfa Aesar
Product number
A10209
Product name
1-Adamantanol, 99%
Packaging
50g
Price
$127
Updated
2020/06/24
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1-Adamantanol Chemical Properties,Usage,Production

Outline

1-adamantanol is also known as 1-hydroxide adamantane, 1-tricyclo [3.3.1.1 (3.7)] decyl alcohol. At room temperature, it is white crystalline powder with the melting point higher than 240 ℃. It is soluble in organic solvents and insoluble in water with sublimation property. It can be used for the manufacture of synthetic adamantane derivatives and adapalene. It can react with vinylidene chloride to generate 1-adamantane acetic acid. 1-adamantyl acetate can further undergo bromination and hydrolyzed into 3-hydroxy-1-adamantyl acetate which can further react with vinylidene chloride to give 1, 3-adamantane di-acetic acid.
1-adamantanol can have Friedel-Crafts alkylation reaction acetanilide in the 98% sulfuric acid medium at room temperature for direct synthesis of 1, 3-bis (4-acetylamino-phenyl) adamantane which can undergo alkaline hydrolysis for synthesis of 1, 3 bis (4-aniline) adamantane. The synthetic route has many advantages including relative high reaction yield and easy purification, etc., therefore greatly facilitating the synthesis of 1, 3-diaryl adamantane derivatives.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Uses

1-adamantanol can be used as the intermediate for synthesis of adamantanes derivatives. For example, it can be used for the manufacture of synthetic adamantane derivatives and adapalene. It can react with vinylidene chloride to give 1-adamantane acetic acid.

Chemical Properties

white to off-white crystalline powder or needles

Synthesis Reference(s)

Synthetic Communications, 19, p. 2061, 1989 DOI: 10.1080/00397918908052598
Tetrahedron Letters, 28, p. 1941, 1987 DOI: 10.1016/S0040-4039(00)96015-5

Purification Methods

If 2-adamantanol is a suspected impurity, then dissolve the substance (10g) in acetone (100mL) and add Jones's reagent [CrO3 (10.3g) in H2O (30mL)], then conc H2SO4 (8.7mL) is added dropwise (turns green in colour) until excess reagent is present (slight red colour). Stir overnight, decant the acetone solution from the Cr salts and adamantan-2-one, dry (Na2SO4) and evaporate to dryness. The residue (ca 7g) is chromatographed through Al2O3 (250g) and washed with 50% *benzene/pet ether (b 40-60o), then 100% Et2O (to remove any adamantan-2-one present) and the 1-adamantanol is then eluted with 5% MeOH in Et2O. The eluate is evaporated, and the residue is recrystallised from pet ether (b 30-60o) at -70o, m 287.2-288.5o. It also crystallises from MeOH and can be sublimed in vacuo. It has characteristic IR, max 3640, 1114, 1086, 982 and 930cm-1. [Schleyer & Nicholas J Am Chem Soc 83 182 1961.] [Beilstein 6 IV 391.] Alternatively, if free from the 2-isomer, dissolve it in tetrahydrofuran, dilute with H2O to precipitate the alcohol. Collect, dry and sublime it in a vacuum at 130o. [Stetter et al. Chem Ber 92 1629 1959.]

1-Adamantanol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Adamantanol Suppliers

Sichuan Zhongbang Pharma CO.,LTD
Tel
0830-2585019
Fax
0830-2589033
Email
sales2@zhongbangst.com
Country
China
ProdList
99
Advantage
69
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TIANJIN MINXIANG BIOMEDICAL INC.
Tel
022-88718329-
Fax
86-22-88718329
Email
tjmx@mxpharm.com
Country
China
ProdList
65
Advantage
58
Jinxiang Chemical (Danyang) Products Co., Ltd.
Tel
025-86819862
Fax
0086-25-86819859
Email
nancyzong@jinchemical.com
Country
China
ProdList
97
Advantage
74
Chengdu bioauto bio-pharmaceutical Technology Co. , Ltd.
Tel
028-61706249-
Email
3491899930@qq.com
Country
China
ProdList
2201
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3579
Advantage
66
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2346
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
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View Lastest Price from 1-Adamantanol manufacturers

Hebei Crovell Biotech Co Ltd
Product
1-Adamantanol 768-95-6
Price
US $10.70/Kg/Bag
Min. Order
10g
Purity
99%
Supply Ability
10000kg
Release date
2021-08-06
Hebei Zhanyao Biotechnology Co. Ltd
Product
1-Adamantanol 768-95-6
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 TONS
Release date
2021-11-17
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-Adamantanol 768-95-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

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