3-Amino-1-adamantanol

Product Name: 3-Amino-1-adamantanol
CAS No.: 702-82-9
Chemical Name: 3-Amino-1-adamantanol
Synonyms: 3-AMINO-1-ADAMANTANOL;3-AMINOADAMANTAN-1-OL;3-Amino-1-admantanol;4-aminoadamantan-1-ol;3-Amino-1-Adamantanamine;3-Hydroxy-1-aminoadamantane;1-AMINO-3-HYDROXYADAMANTANE;C1oH17NO;AKOS BB-9784;CHEMBRDG-BB 4003530
CBNumber: CB5777891
Molecular Formula: C10H17NO
Formula Weight: 167.25
MOL File: 702-82-9.mol

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3-Amino-1-adamantanol Property

Melting point:: 265 °C (dec.)(lit.)
Boiling point:: 266.8±23.0 °C(Predicted)
Density: 1.252±0.06 g/cm3(Predicted)
Flash point:: 230 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Crystalline Powder
pka: 15.07±0.40(Predicted)
color: White to yellow
Water Solubility: Soluble in organic solvents,insoluble in water.
InChI: InChI=1S/C10H17NO/c11-9-2-7-1-8(3-9)5-10(12,4-7)6-9/h7-8,12H,1-6,11H2
InChIKey: DWPIPTNBOVJYAD-UHFFFAOYSA-N
SMILES: C12(O)CC3CC(CC(N)(C3)C1)C2
CAS DataBase Reference: 702-82-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29221990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 523690
Product name: 3-Amino-1-adamantanol
Purity: 96%
Packaging: 1g
Price: $26.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 523690
Product name: 3-Amino-1-adamantanol
Purity: 96%
Packaging: 5g
Price: $39.14
Updated: 2025/07/31

TCI Chemical

Product number: A2079
Product name: 3-Amino-1-adamantanol Hydrate
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $17
Updated: 2025/07/31

TCI Chemical

Product number: A2079
Product name: 3-Amino-1-adamantanol Hydrate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $40
Updated: 2025/07/31

TRC

Product number: A580300
Product name: 1-Amino-3-adamantanol
Packaging: 1g
Price: $100
Updated: 2021/12/16

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3-Amino-1-adamantanol Chemical Properties,Usage,Production

Description

3-Amino-1-adamantanol is an important adamantane drug intermediate mainly used in the synthesis of inhibitors with antihyperglycaemic properties for the preparation of Vildagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor used in the treatment of type 2 diabetes.

Chemical Properties

White solid

Uses

It is employed in the synthesis of inhibitors with antihyperglycemic properties. vil- dagliptin is synthesised from 3-Amino-1-adamantanol.

Uses

3-Amino-1-hydroxyadamantane can be employed in the synthesis of inhibitors with antihyperglycemic properties.

Uses

As reagent, 3-Amino-1-hydroxyadamantane can be used in the preparation of Vildagliptin.

Synthesis

A preparation method of 3-amino-1-adamantanol comprises the following steps: (1) adding amantadine or a salt thereof to sulfuric acid at 10-30°C and adding a mixed acid dropwise to perform a nitration reaction to obtain a reaction liquid; (2) adding the reaction liquid to water and mixing the reaction liquid with water to obtain a mixed solution; (3) performing a hydroxylation reaction under the effect of alkaline to obtain the 3-amino-1-adamantanol. The preparation method employs the raw material, is easy to obtain, is simple in operations, is environmentally protective, is low in cost, and is high in yield, which is generally higher than 80%, maximally 90.1%.

References

[1] Pharmaceutical Chemistry Journal, 1990, vol. 24, # 1, p. 35 - 39
[2] Khimiko-Farmatsevticheskii Zhurnal, 1990, vol. 24, # 1, p. 29 - 31
[3] Tetrahedron Letters, 2017, vol. 58, # 15, p. 1456 - 1458
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 3, p. 947 - 964
[5] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 554 - 564

3-Amino-1-adamantanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Amino-1-adamantanol manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: 3-Amino-1-adamantanol 702-82-9
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-30

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 3-Amino-1-adamantanol 702-82-9
Price: US $99.00-66.00/kg
Min. Order: 0.0010000000474974513kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-19

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 3-Amino-1-adamantanol 702-82-9
Price: US $40.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-05-17

702-82-9, 3-Amino-1-adamantanolRelated Search:

Adamantane Glycine ALTRENOGEST Betaine Altrenogest Amantadine PotassiuM sodiuM Dehydroandrographolide Succinate 1-Adamantanol 3-Amino-1-propanesulfonic acid 3-Amino-1,2-propanediol Dichloroacetyl chloride Vildagliptin Impurity 25 Vildagliptin Impurity 6 Vildagliptin IMpurity 2 (Mixture of DiastereoMers) N-acetic acid-1-aMino-3-adaMantanol Vildagliptin Impurity 19 1,3,5,7-tetrahydroxyadamantane 2-Pyrrolidinecarbonitrile,1-acetyl-,(2S)-(9CI)

CHEMBRDG-BB 4003530

3-AMINO-1-ADAMANTANOL

3-Amino-1-hydroxyadamantane

3-AMINOADAMANTAN-1-OL

AKOS BB-9784

1-AMINO-3-ADAMANTANOL

1-AMINO-3-HYDROXYADAMANTANE

3-Hydroxy-1-aminoadamantane

TRICYCLO[3.3.1.13,7]DECAN-1-OL, 3-AMINO-

Vigliptin impurity 15

4-aminoadamantan-1-ol

(5r,7s)-3-aminoadamantan-1-ol

3-Amino-1-adamantanol Hydrate

3-aminoadamantan-1-ol(SALTDATA: HCl)

Vildagliptin Intermediate 1

1-AMino adaMantane-3-ol

3-AMino-1-adaMantanole 3

(3-HydroxyadaMantan-1-yl)aMine

3-AMino-tricyclo[3.3.1.13,7]decan-1-ol

3-AMino-1-adaMantanol, 98+%

3-Aminoadamantan-1-ol, 3-Aminotricyclo[3.3.1.1~3,7~]decan-1-ol, 3-Hydroxytricyclo[3.3.1.1~3,7~]decan-1-amine

Vildagliptin Amino Alcohol Impurity

3-AMino-1-HydroxyadaMantane SynonyMs: 3-AMinoadaMantan-1-ol

3-AMino-1-adaMantano, 98%

3 - aMino adaMantane alcohol

3-Amino-1-hydroxyadamantane 3-Aminoadamantan-1-ol

3-Amino-1-adamantanol 3-Amino-1-adamantanol

3-aminoadamantan-1-ol hydrochloride

Vildagliptin Impurity 24

3-Amino-1-hydroxyadamantane (Vildagliptin)

3-Amino-1-admantanol

3-Amino-1-adamantanol Hydrate&gt

3-amino-1-amantadine

3-Amino-1-hydroxyadamantane USP/EP/BP

Vildagliptin Impurity 74

Vildagliptin Amino Alcohol Impurity/Vildagliptin Impurity 15

3-Amino-1-Adamantanamine

Vildagliptin VLN-01(3-Hydroxy-1-adamantan amine)

Vildagliptin Amino Alcohol ImpurityQ: What is Vildagliptin Amino Alcohol Impurity Q: What is the CAS Number of Vildagliptin Amino Alcohol Impurity Q: What is the storage condition of Vildagliptin Amino Alcohol Impurity Q: What are the applications of Vildagliptin Amino Alcohol Impurity

3-AMINO-1-ADAMNANOL

3-Amino -1-Adamantol

2-Amino-1-Hydroxyadamantane

3-amino-1-hydroxy Ademantane

1-Amino-3- Admatanol

C1oH17NO

3-Amino-1-Adamentanol

Vildagliptin Amino Alcohol Impurity 1-Amino-3-adamantanol

3-Aminoadamantan-ol

Vildagliptin Impurity: 1-Amino-3-adamantanol

702-82-9

02-82-9

702-82-7

702-89-2

C10H18NO

C10H17NOxH2O

C10H17NOH2O

Building Blocks

Amino Alcohols