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Calcium citrate

Description References
Product Name
Calcium citrate
CAS No.
813-94-5
Chemical Name
Calcium citrate
Synonyms
citrical;acicontral;Calsium citrate;Calcium citrate;DICALCIUMCITRATE;Tricalcium citrate;CALCIUM CITRATE USP;TRICALCIUM DICITRATE;CALCIUM CITRATE pure;tribasiccalciumcitrate
CBNumber
CB7153589
Molecular Formula
C12H10Ca3O14
Formula Weight
498.43
MOL File
813-94-5.mol
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Calcium citrate Property

solubility 
0.1 M HCl: 0.01 M at 20 °C, clear, colorless
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
813-94-5(CAS DataBase Reference)
EPA Substance Registry System
Tricalcium citrate (813-94-5)
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Safety

WGK Germany 
1
Hazardous Substances Data
813-94-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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Calcium citrate Chemical Properties,Usage,Production

Description

Calcium citrate, a naturally occurring chemical in most plants and animals, is the calcium salt derived from citric acid. Calcium citrate is present in foods which have naturally occurring citric acid. Calcium citrate is used as a calcium supplement and may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). Calcium citrate may be chemopreventive for colon and other cancers. Calcium citrate is used as an ingredient in dietary supplements, and as a nutrient, sequestrant, buffer, antioxidant, firming agent, acidity regulator (in jams and jellies, soft drinks and wines), as a raising agent and an emulsifying salt. It is also used to improve the baking properties of flours and as a stabilizer.

References

  1. https://www.cancer.gov
  2. https://www.drugs.com
  3. https://www.webmd.com
  4. https://www.livestrong.com
  5. https://www.ams.usda.gov

Description

Calcium citrate is the calcium salt of citric acid. It is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate. Calcium citrate is also used as a water softener because the citrate ions can chelate unwanted metal ions. Calcium citrate is also found in some dietary calcium supplements (e.g. Citracal). Calcium makes up 21% of calcium citrate by weight.

Chemical Properties

white powder or white to colourless crystals

Production Methods

Calcium citrate is an intermediate in the isolation of citric acid from the fermentation process by which citric acid is produced industrially. The citric acid in the broth solution is neutralized by calcium hydroxide, precipitating insoluble calcium citrate. This is then filtered off from the rest of the broth and washed to give clean calcium citrate.
The calcium citrate thus produced may be sold as-is, or it may be converted to citric acid using dilute sulfuric acid.

Pharmaceutical Applications

Calcium citrate is more easily absorbed (bioavailability is 2.5 times higher than calcium carbonate); it is easier to digest and less likely to cause constipation and gas than calcium carbonate. Calcium citrate can be taken without food and is more easily absorbed than calcium carbonate on an empty stomach. It is also believed that it contributes less to the formation of kidney stones. Calcium citrate consists of around 24% Ca2+, which means that 1000 mg calcium citrate contains around 240 mg Ca2+. The lower Ca2+ content together with the higher price makes it a more expensive treatment option compared to calcium carbonate, but its slightly different application field can justify this.

Biological Activity

In many individuals, bioavailability of calcium citrate is found to be equal to that of the cheaper calcium carbonate.However, alterations to the digestive tract may change how calcium is digested and absorbed. Unlike calcium carbonate, which is basic and neutralizes stomach acid, calcium citrate has no effect on stomach acid. Individuals who are sensitive to antacids or who have difficulty producing adequate stomach acid should choose calcium citrate over calcium carbonate for supplementation. According to recent research into calcium absorption after gastric bypass surgery , calcium citrate may have improved bioavailability over calcium carbonate in Rouxen- Y gastric bypass patients who are taking calcium citrate as a dietary supplement after surgery. This is mainly due to the changes related to where calcium absorption occurs in the digestive tract of these individuals.

Calcium citrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Calcium citrate Suppliers

Lianyungang Kexin Chemical Co., Ltd.
Tel
518-85110578-
Email
sales3257@jskolod.com
Country
China
ProdList
100
Advantage
58
Adamas Reagent, Ltd.
Tel
400-600-9262
Email
bxy@titansci.com
Country
China
ProdList
13915
Advantage
59
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9844
Advantage
79
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852-
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2957
Advantage
58
Beijing Universal Century Technology Co., Ltd.
Tel
400-8706899
Fax
400-8706899
Email
hysj_bj.com
Country
China
ProdList
3602
Advantage
55
Vientiane Tianjin Hengyuan Technology Co., Ltd.
Tel
15722085254
Fax
022-26358246
Email
phytochemical@126.com
Country
China
ProdList
813
Advantage
55
RiZhao LiDeShi Chemical Co., Ltd.
Tel
010-51268198
Fax
010-63833209
Email
leadershipchem@126.com
Country
China
ProdList
2560
Advantage
58
Mei Lan Industrial (Shanghai) Co., Ltd.
Tel
021-61500788
Fax
021-58957967
Email
wouchina@126.com
Country
China
ProdList
2680
Advantage
55
Dalian Rivin Technology Co., Ltd
Tel
86-0411-62789512
Fax
86-0411-62789510
Email
xj_cui@dlrivin.com
Country
China
ProdList
123
Advantage
56
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Email
xingcanyaoye@sina.com;
Country
China
ProdList
2250
Advantage
58
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View Lastest Price from Calcium citrate manufacturers

qingdao trust agri chemical co.,ltd
Product
Calcium Citrate 813-94-5
Price
US $25.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100ton/month
Release date
2021-09-29
Wuhan Mulei New Material Technology Co. Ltd
Product
Calcium citrate 813-94-5
Price
US $10.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
5000tons per month
Release date
2021-04-06
Baoji Guokang Bio-Technology Co., Ltd.
Product
Calcium citrate 813-94-5
Price
US $8.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2021-06-08

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