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Calcium citrate

Description References
Product Name
Calcium citrate
CAS No.
813-94-5
Chemical Name
Calcium citrate
Synonyms
Tricalcium citrate;tribasiccalciumcitrate;Tricalcium Citrate anhydrous;citrical;acicontral;Calsium citrate;Calcium citrate;DICALCIUMCITRATE;CALCIUM CITRATE USP;TRICALCIUM DICITRATE
CBNumber
CB7153589
Molecular Formula
C12H10Ca3O14
Formula Weight
498.43
MOL File
813-94-5.mol
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Calcium citrate Property

solubility 
0.1 M HCl: 0.01 M at 20 °C, clear, colorless
Odor
at 100.00?%. odorless
Stability:
Stable. Incompatible with strong oxidizing agents.
LogP
-1.721 (est)
CAS DataBase Reference
813-94-5(CAS DataBase Reference)
EPA Substance Registry System
Tricalcium citrate (813-94-5)
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Safety

WGK Germany 
1
Hazardous Substances Data
813-94-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific
Product number
5928AF
Product name
Calciumcitrate,anhydrous
Packaging
100g
Price
$24
Updated
2021/12/16
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Calcium citrate Chemical Properties,Usage,Production

Description

Calcium citrate, a naturally occurring chemical in most plants and animals, is the calcium salt derived from citric acid. Calcium citrate is present in foods which have naturally occurring citric acid. Calcium citrate is used as a calcium supplement and may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). Calcium citrate may be chemopreventive for colon and other cancers. Calcium citrate is used as an ingredient in dietary supplements, and as a nutrient, sequestrant, buffer, antioxidant, firming agent, acidity regulator (in jams and jellies, soft drinks and wines), as a raising agent and an emulsifying salt. It is also used to improve the baking properties of flours and as a stabilizer.

References

  1. https://www.cancer.gov
  2. https://www.drugs.com
  3. https://www.webmd.com
  4. https://www.livestrong.com
  5. https://www.ams.usda.gov

Description

Calcium citrate is the calcium salt of citric acid. It is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate. Calcium citrate is also used as a water softener because the citrate ions can chelate unwanted metal ions. Calcium citrate is also found in some dietary calcium supplements (e.g. Citracal). Calcium makes up 21% of calcium citrate by weight.

Chemical Properties

white powder or white to colourless crystals

Production Methods

Calcium citrate is an intermediate in the isolation of citric acid from the fermentation process by which citric acid is produced industrially. The citric acid in the broth solution is neutralized by calcium hydroxide, precipitating insoluble calcium citrate. This is then filtered off from the rest of the broth and washed to give clean calcium citrate.
The calcium citrate thus produced may be sold as-is, or it may be converted to citric acid using dilute sulfuric acid.

Definition

ChEBI: Calcium citrate is an organic calcium salt composed of calcium cations and citrate anions in a 3:2 ratio. It has a role as a nutraceutical, a food additive, a food preservative and a flavouring agent. It contains a citrate(3-).

Flammability and Explosibility

Non flammable

Pharmaceutical Applications

Calcium citrate is more easily absorbed (bioavailability is 2.5 times higher than calcium carbonate); it is easier to digest and less likely to cause constipation and gas than calcium carbonate. Calcium citrate can be taken without food and is more easily absorbed than calcium carbonate on an empty stomach. It is also believed that it contributes less to the formation of kidney stones. Calcium citrate consists of around 24% Ca2+, which means that 1000 mg calcium citrate contains around 240 mg Ca2+. The lower Ca2+ content together with the higher price makes it a more expensive treatment option compared to calcium carbonate, but its slightly different application field can justify this.

Biological Activity

In many individuals, bioavailability of calcium citrate is found to be equal to that of the cheaper calcium carbonate.However, alterations to the digestive tract may change how calcium is digested and absorbed. Unlike calcium carbonate, which is basic and neutralizes stomach acid, calcium citrate has no effect on stomach acid. Individuals who are sensitive to antacids or who have difficulty producing adequate stomach acid should choose calcium citrate over calcium carbonate for supplementation. According to recent research into calcium absorption after gastric bypass surgery , calcium citrate may have improved bioavailability over calcium carbonate in Rouxen- Y gastric bypass patients who are taking calcium citrate as a dietary supplement after surgery. This is mainly due to the changes related to where calcium absorption occurs in the digestive tract of these individuals.

Calcium citrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Calcium citrate manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Calcium Citrate 813-94-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-03-26
Hebei Duling International Trade Co. LTD
Product
Calcium Citrate 813-94-5
Price
US $3.20/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
20tons
Release date
2023-02-22
Hebei Dongdu Import and Export Co. LTD
Product
calcium citrate 813-94-5
Price
US $1.85/kg
Min. Order
1000kg
Purity
99%
Supply Ability
5000 Tons/Year
Release date
2023-11-21

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