ChemicalBook > CAS DataBase List > 3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE

3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE

Product Name: 3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE
CAS No.: 24623-65-2
Chemical Name: 3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE
Synonyms: 3-TERT-BUTYLSALICYLALDEHYDE;3-tert-Butylsalicylaldehyde >3-t-Butyl-2-hydroxybenzaldehyde;3-tert-butyl salicylic aldehyde;3-tert-butyl-2-hydroxybenzaldehy;2-Hydroxy-3-tert-butylbenzaldehyde;3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE;3-tert-Butyl-2-hydroxybenzaldehyde 96%;001ERT-BUTYL-2-HYDROXYBENZALDEHYDE, 96%;3-tert-Butyl-2-hydroxybenzaldehyde
CBNumber: CB4311777
Molecular Formula: C11H14O2
Formula Weight: 178.23
MOL File: 24623-65-2.mol

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3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE Property

Boiling point:: 78-79 °C/1 mmHg (lit.)
Density: 1.041 g/mL at 25 °C (lit.)
refractive index: n20/D 1.544(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Soluble), DMSO (Sparingly)
form: Oil
pka: 9.55±0.10(Predicted)
color: Pale Yellow to Light Yellow
InChI: InChI=1S/C11H14O2/c1-11(2,3)9-6-4-5-8(7-12)10(9)13/h4-7,13H,1-3H3
InChIKey: ROILLNJICXGZQQ-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=CC(C(C)(C)C)=C1O
EPA Substance Registry System: Benzaldehyde, 3-(1,1-dimethylethyl)-2-hydroxy- (24623-65-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29125000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 481874
Product name: 3-tert-Butyl-2-hydroxybenzaldehyde
Purity: 96%
Packaging: 5g
Price: $154
Updated: 2025/07/31

Sigma-Aldrich

Product number: 481874
Product name: 3-tert-Butyl-2-hydroxybenzaldehyde
Purity: 96%
Packaging: 25g
Price: $729
Updated: 2025/07/31

TCI Chemical

Product number: B4016
Product name: 3-tert-Butylsalicylaldehyde
Purity: >95.0%(GC)
Packaging: 1g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: B4016
Product name: 3-tert-Butylsalicylaldehyde
Purity: >95.0%(GC)
Packaging: 5g
Price: $120
Updated: 2025/07/31

TRC

Product number: T135715
Product name: 3-tert-Butyl-2-hydroxybenzaldehyde
Packaging: 1g
Price: $40
Updated: 2021/12/16

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3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

light yellow liquid

Uses

3-tert-Butyl-2-hydroxybenzaldehyde is used in preparation of coumarin derivative.

General Description

3-tert-Butyl-2-hydroxybenzaldehyde is a mono-tert-butyl substituted 2-hydroxybenzaldehyde that can be synthesized using ethylbromide and 2-tert-butylphenol.

Synthesis

50-00-0

88-18-6

24623-65-2

Triethylamine (8.35 mL, 60 mmol) was added dropwise to a stirred suspension of 2-tert-butylphenol (4.55 g, 30 mmol), magnesium chloride (5.71 g, 60 mmol) and paraformaldehyde (2.08 g, 66 mmol) in THF (120 mL) at room temperature. The reaction mixture was heated to reflux with continuous stirring for 3 h. An orange-colored suspension was obtained upon completion of the reaction. The crude product was extracted with EtOAc (3 x 50 mL). If a permanent emulsion is formed, a small amount of diluted HCl is added to break the emulsion. The organic layers were combined, dried with anhydrous MgSO4, filtered and concentrated under reduced pressure to give a light yellow oily product which did not require further purification. The product may gradually change to dark green color during storage. Yield: 90%. The product was a light yellow oil.1H-NMR (CDCl3, 300 MHz) δH: 1.44 (9H, s, 3×CH3), 6.97 (1H, t, J = 7.5 Hz, HAr), 7.41 (1H, dd, J = 1.5 Hz, J = 7.5 Hz, HAr), 7.54 (1H, dd, J = 1.2 Hz, J = 7.5 Hz, HAr), 9.88 (1H, s, CHO), 11.82 (1H, s, OH).

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 7, p. 1658 - 1667
[2] Advanced Synthesis and Catalysis, 2017, vol. 359, # 22, p. 3990 - 4001
[3] Patent: WO2008/132474, 2008, A1. Location in patent: Page/Page column 31
[4] Advanced Synthesis and Catalysis, 2009, vol. 351, # 9, p. 1325 - 1332
[5] Patent: WO2009/109765, 2009, A1. Location in patent: Page/Page column 27; 28

3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE Suppliers

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View Lastest Price from 3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE 24623-65-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-02-12

Anhui Ruihan Technology Co., Ltd

Product: 3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE 24623-65-2
Price: US $80.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000tons
Release date: 2023-09-11

LY Global chemicals co.,ltd .

Product: 3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE 24623-65-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100kg
Release date: 2023-03-19

24623-65-2, 3-TERT-BUTYL-2-HYDROXYBENZALDEHYDERelated Search:

(-)-USNIC ACID USNIC ACID 3,5-Di-tert-butylsalicylaldehyde 3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE (+)-Usniacin 6,8-DI(TERT-BUTYL)-4-OXO-4H-CHROMENE-2-CARBOXYLIC ACID 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3(2H,9bH)-dione monosodium salt 9-Formyl-8-hydroxy-1,1,7,7-tetramethyljulolidine ZINC 3 5-DI-TERT-BUTYLSALICYLATE 97 3,5-Bis-tert-butylsalicylic acid 4-TERT-BUTYL-2-HYDROXYBENZALDEHYDE 3,5-DI-TERT-BUTYL-4-HYDROXYBENZALDEHYDE HEMIHYDRATE 3,5-Di-Tert-Butyl-P-Hydroxybenzaldehyde ,3,5-Di-tert-butyl-4-hydroxybenzaldehyde, 98+%,3,5-DI-TERT-BUTYL-4-HYDROXYBENZALDEHYDE 5-TERT-BUTYL-2-HYDROXY-BENZALDEHYDE furaquinocin A 2,7-DI-TERT-BUTYL-9,9-DIMETHYL-4,5-XANTHENEDICARBOXYLIC ACID 3-tert-butyl-2-hydroxy-6-methylbenzoic acid 3-Tert-butyl-5-methylsalicylicacid

3-TERT-BUTYLSALICYLALDEHYDE

3-TERT-BUTYL-2-HYDROXYBENZALDEHYDE

001ERT-BUTYL-2-HYDROXYBENZALDEHYDE, 96%

3-tert-Butyl-2-hydroxybenzaldehyde,3-tert-Butylsalicylaldehyde

Benzaldehyde, 3-(1,1-diMethylethyl)-2-hydroxy-

2-Hydroxy-3-tert-butylbenzaldehyde

3-t-Butyl-2-hydroxybenzaldehyde

3-tert-butyl-2-hydroxybenzaldehy

3-tert-Butyl-2-hydroxybenzaldehyde

3-tert-Butyl-2-hydroxybenzaldehyde 96%

3-tert-Butylsalicylaldehyde &gt

3-tert-butyl salicylic aldehyde

3-tert-Butyl-2-hydroxybenzaldehyde

24623-65-2

CH33CC6H3OHCHO

Carbonyl Compounds

Building Blocks

C10 to C21

Organic Building Blocks

Aldehydes

Building Blocks

C10-C12

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

john's