RSL3

Product Name: RSL3
CAS No.: 1219810-16-8
Chemical Name: RSL3
Synonyms: RSL;(1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate;RSL3;RSL3 1S;3R-RSL3;CS-2409;1S,3R-RSL3;RSL 3;RSL-3;RSL3 (1S,3R-);RSL3, 10 mM in DMSO
CBNumber: CB43126772
Molecular Formula: C23H21ClN2O5
Formula Weight: 440.88
MOL File: 1219810-16-8.mol

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RSL3 Property

Boiling point:: 641.3±55.0 °C(Predicted)
Density: 1.368±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO (45 mg/ml)
pka: 16.09±0.60(Predicted)
form: solid
color: Off-white
optical activity: [α]/D 9.0 to 15.0°, c =0.5 in methanol
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey: TXJZRSRTYPUYRW-NQIIRXRSSA-N
SMILES: N1C2=C(C=CC=C2)C2C[C@H](C(OC)=O)N(C(CCl)=O)[C@@H](C3=CC=C(C(OC)=O)C=C3)C1=2

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Safety

WGK Germany: WGK 3
HS Code: 2933998090
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19288
Product name: (1S,3R)-RSL3
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19288
Product name: (1S,3R)-RSL3
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 19288
Product name: (1S,3R)-RSL3
Purity: ≥98%
Packaging: 10mg
Price: $199
Updated: 2024/03/01

Cayman Chemical

Product number: 19288
Product name: (1S,3R)-RSL3
Purity: ≥98%
Packaging: 25mg
Price: $420
Updated: 2024/03/01

Tocris

Product number: 6118
Product name: 1S,3R-RSL3
Purity: ≥98%(HPLC)
Packaging: 10
Price: $216
Updated: 2021/12/16

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RSL3 Chemical Properties,Usage,Production

Description

RSL3 (1219810-16-8) Inhibits glutathione peroxidase (GPX4) inducing ferroptosis.1,2 Effectively induces ferroptosis in glioblastoma cells.3 Everolimus in combination with RSL3 synergistically inhibits the viability of renal cell carcinoma (RCC) cells suggesting a mechanism by which RCC drug resistance may be overcome.4

Uses

RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells[1].

in vitro

rsl3, which was a glutathione peroxidase (gpx) 4 inhibitor, had been cooperated with the smac mimetic bv6 to induce reactive oxygen species (ros)-dependent cell death in acute lymphoblastic leukemia cells. it was found that addition of the caspase inhibitor failed to rescue ros-induced cell death, suggesting that rsl3-induced cell death occured in a caspase-independent manner. moreover, the iron chelator deferoxamine inhibited rsl3/bv6-induced cell death significantly, however, it could not rescue cell death by erastin/bv6, indicating that rsl3/bv6-, but not erastin/bv6-mediated cell death depended on iron. in addition, it was shown that ros production was required for both rsl3/bv6- and erastin/bv6-induced cell death. in contrast, genetic or pharmacological inhibition of lipid peroxidation by gpx4 overexpression significantly decreased rsl3/bv6-induced cell death. of importance, inhibition of lipid peroxidation could protect from rsl3/bv6-stimulated ros production [1].

in vivo

RSL3 (100 mg/kg, Intratumorally twice per week for 20 days) significantly inhibits the growth of tumor in combination with Trigonelline (HY-N0414) in mice bearing HN3R cells^[1].

Animal Model:	Ten-week-old athymic BALB/c male nude mice (nu/nu) bearing HN3R cells^[1]
Dosage:	100 mg/kg in combination with trigonelline (50 mg/kg)
Administration:	Intratumorally twice per week for 20 days
Result:	Significantly reduced the volume of tumor combined with trigonelline in mice.

IC 50

100 nm

storage

Store at -20°C

References

[1] WAN SEOK YANG. Regulation of ferroptotic cancer cell death by GPX4.[J]. Cell, 2014: 317-331. DOI:10.1016/j.cell.2013.12.010
[2] VALERIAN E KAGAN. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis[J]. Nature chemical biology, 2016, 13 1: 81-90. DOI:10.1038/nchembio.2238
[3] SHENGBIAO LI. RSL3 Drives Ferroptosis through NF-κB Pathway Activation and GPX4 Depletion in Glioblastoma.[J]. Oxidative Medicine and Cellular Longevity, 2021: 2915019. DOI:10.1155/2021/2915019
[4] WANG YANGYUN . Everolimus accelerates Erastin and RSL3-induced ferroptosis in renal cell carcinoma[J]. Gene, 2022, 809: Article 145992. DOI:10.1016/j.gene.2021.145992

RSL3 Preparation Products And Raw materials

Raw materials

Preparation Products

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RSL3 Suppliers

China 200 India 1 United Kingdom 1 United States 13 Global 215

Fujian boshi pharmaceutical technology co. LTD

Tel: 0595-22008920; 18120708884
Email: 393612455@qq.com
Country: China
ProdList: 255
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44802
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4765
Advantage: 58

Nanjing Dulai Biotechnology Co., Ltd.

Tel: 025-846993838003-8003 18013301590
Fax: 025-84699383-8003
Email: njduly@126.com
Country: China
ProdList: 3253
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 8000
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15872
Advantage: 55

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View Lastest Price from RSL3 manufacturers

Career Henan Chemical Co

Product: RSL3 1219810-16-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kgs
Release date: 2019-12-17

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(1S,3R)-Methyl 2-(2-chloroacetyl)-1-(4-(methoxycarbonyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

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RSL3, 10 mM in DMSO

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1219810-16-8

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