RSL3

Product Name: RSL3
CAS No.: 1219810-16-8
Chemical Name: RSL3
Synonyms: RSL;(1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate;RSL3;RSL3 1S;3R-RSL3;CS-2409;1S,3R-RSL3;RSL 3;RSL-3;RSL3 (1S,3R-);RSL3 1S;3R-;1S;3R-RSL3
CBNumber: CB43126772
Molecular Formula: C23H21ClN2O5
Formula Weight: 440.88
MOL File: 1219810-16-8.mol

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RSL3 Property

Boiling point:: 641.3±55.0 °C(Predicted)
Density: 1.368±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO (45 mg/ml)
pka: 16.09±0.60(Predicted)
form: solid
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19288
Product name: (1S,3R)-RSL3
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19288
Product name: (1S,3R)-RSL3
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 19288
Product name: (1S,3R)-RSL3
Purity: ≥98%
Packaging: 10mg
Price: $199
Updated: 2024/03/01

Cayman Chemical

Product number: 19288
Product name: (1S,3R)-RSL3
Purity: ≥98%
Packaging: 25mg
Price: $420
Updated: 2024/03/01

Tocris

Product number: 6118
Product name: 1S,3R-RSL3
Purity: ≥98%(HPLC)
Packaging: 50
Price: $908
Updated: 2021/12/16

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RSL3 Chemical Properties,Usage,Production

Description

RSL3 (1219810-16-8) Inhibits glutathione peroxidase (GPX4) inducing ferroptosis.1,2? Effectively induces ferroptosis in glioblastoma cells.3? Everolimus in combination with RSL3 synergistically inhibits the viability of renal cell carcinoma (RCC) cells suggesting a mechanism by which RCC drug resistance may be overcome.4

in vitro

rsl3, which was a glutathione peroxidase (gpx) 4 inhibitor, had been cooperated with the smac mimetic bv6 to induce reactive oxygen species (ros)-dependent cell death in acute lymphoblastic leukemia cells. it was found that addition of the caspase inhibitor failed to rescue ros-induced cell death, suggesting that rsl3-induced cell death occured in a caspase-independent manner. moreover, the iron chelator deferoxamine inhibited rsl3/bv6-induced cell death significantly, however, it could not rescue cell death by erastin/bv6, indicating that rsl3/bv6-, but not erastin/bv6-mediated cell death depended on iron. in addition, it was shown that ros production was required for both rsl3/bv6- and erastin/bv6-induced cell death. in contrast, genetic or pharmacological inhibition of lipid peroxidation by gpx4 overexpression significantly decreased rsl3/bv6-induced cell death. of importance, inhibition of lipid peroxidation could protect from rsl3/bv6-stimulated ros production [1].

IC 50

100 nm

storage

Store at -20°C

References

Yang et al. (2014), Regulation of ferroptotic cancer cell death by GPX4; Cell 156 317 Kagan et al. (2017), Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis; nAT. Chem. Biol. 13 81 Shengbiao et al. (2021), RSL3 Drives Ferroptosis through NF-kB Pathway Activation and GPX4 depletion in Glioblastoma; oXID. Med. Cell. Longev. 2021 2915019 Yangyun et al. (2022), Everolimus accelerates Erastin and RSL3-induced ferroptosis in renal cell carcinoma; Gene 809 145992

RSL3 Preparation Products And Raw materials

Raw materials

Preparation Products

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RSL3 Suppliers

China 107 India 1 United Kingdom 1 United States 13 Global 122

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

ApexBio Technology

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ProdList: 6251
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Focus Biomolecules

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ProdList: 1284
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Abcam

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Email: us.orders@abcam.com
Country: United States
ProdList: 6001
Advantage: 50

Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

MedChemExpress

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Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Combi-Blocks Inc.

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Country: United States
ProdList: 6618
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View Lastest Price from RSL3 manufacturers

Career Henan Chemical Co

Product: RSL3 1219810-16-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kgs
Release date: 2019-12-17

1219810-16-8, RSL3Related Search:

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(1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate

CS-2409

methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methoxycarbonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate

RSL 3;RSL-3

RSL3 1S;3R-;1S;3R-RSL3

3R-RSL3

RSL3 1S

RSL3

RSL3 (1S,3R-)

1S,3R-RSL3

RSL

1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-, methyl ester, (1S,3R)-

1S,3R-RSL 3 >=98% (HPLC)

(1S,3R)-Methyl 2-(2-chloroacetyl)-1-(4-(methoxycarbonyl)phenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

RSL-3,inhibit,Ferroptosis,(1S,3R)-RSL3,RSL 3,Inhibitor,RSL3,Glutathione Peroxidase

Methyl (1S,3R)-2-(2-Chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Ceftobiprole Impurity 25

1219810-16-8

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