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SBI-0640756

Product Name
SBI-0640756
CAS No.
1821280-29-8
Chemical Name
SBI-0640756
Synonyms
SBI756;SBI 756;CS-2838;SBI-756;SBI-0640756;SBI-0640756, 10 mM in DMSO;SBI-0640756;SBI 0640756;SBI0640756;SBI 756;SBI756;SBI-756;(E)-6-chloro-3-(3-(5-fluoropyridin-3-yl)acryloyl)-4-phenylquinolin-2(1H)-one;2(1H)-Quinolinone,6-chloro-3-[(2E)-3-(5-fluoro-3-pyridinyl)-1-oxo-2-propen-1-yl]-4-phenyl-;Autophagy,Inhibitor,SBI756,SBI 756,SBI0640756,Eukaryotic Initiation Factor (eIF),inhibit,SBI-0640756
CBNumber
CB43133350
Molecular Formula
C23H14ClFN2O2
Formula Weight
0
MOL File
Mol file
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SBI-0640756 Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO : ≥ 26 mg/mL (64.23 mM)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5696
Product name
SBI-0640756
Purity
98.52%
Packaging
2mg
Price
$132
Updated
2021/12/16
ChemScene
Product number
CS-5696
Product name
SBI-0640756
Purity
98.52%
Packaging
5mg
Price
$216
Updated
2021/12/16
ChemScene
Product number
CS-5696
Product name
SBI-0640756
Purity
98.52%
Packaging
10mg
Price
$360
Updated
2021/12/16
ChemScene
Product number
CS-5696
Product name
SBI-0640756
Purity
98.52%
Packaging
25mg
Price
$720
Updated
2021/12/16
ChemScene
Product number
CS-5696
Product name
SBI-0640756
Purity
98.52%
Packaging
50mg
Price
$1188
Updated
2021/12/16
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SBI-0640756 Chemical Properties,Usage,Production

Uses

SBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex.

Biological Activity

SBI-0640756 is a potent inhibitor of eIF4G1 th at disrupts the eIF4F complex assembly independently of mTOR. SBI-0640756 potently inhibits growth of BRAF-resistant and BRAF-independent melanomas including NRAS- and NF1-mutant melanomas. SBI-0640756 exhibits low toxicity against nontransformed fibroblasts. SBI-0640756 also suppressed AKT and NF-kB signaling.

in vivo

SBI-0640756 (SBI-756) (0.5 mg/kg, i.p.) delays tumor onset and reduces tumor incidence by 50% in NrasQ61K/Ink4a–/– genetic model. SBI-0640756 (SBI-756) (1 mg/kg, 2 times per week, i.p.) in combination with BRAF inhibitor potently suppresses growth of established tumors and does not resume tumor growth in immunodeficient mice bearing A375 tumors[1].

IC 50

eIF4

References

[1] Feng Y et al. SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Res, 2015 Dec 15, 75(24):5211-8. DOI:10.1158/0008-5472.CAN-15-0885

SBI-0640756 Preparation Products And Raw materials

Raw materials

Preparation Products

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SBI-0640756 Suppliers

China 59 India 1 United States 6 Global 66
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

1821280-29-8, SBI-0640756Related Search:

SBI-0206965

  • SBI-0640756
  • (E)-6-chloro-3-(3-(5-fluoropyridin-3-yl)acryloyl)-4-phenylquinolin-2(1H)-one
  • CS-2838
  • SBI 756
  • SBI-0640756;SBI 0640756;SBI0640756;SBI 756;SBI756;SBI-756
  • SBI756
  • SBI-756
  • 2(1H)-Quinolinone,6-chloro-3-[(2E)-3-(5-fluoro-3-pyridinyl)-1-oxo-2-propen-1-yl]-4-phenyl-
  • Autophagy,Inhibitor,SBI756,SBI 756,SBI0640756,Eukaryotic Initiation Factor (eIF),inhibit,SBI-0640756
  • SBI-0640756, 10 mM in DMSO
  • 1821280-29-8