SBI-0206965
- Product Name
- SBI-0206965
- CAS No.
- 1884220-36-3
- Chemical Name
- SBI-0206965
- Synonyms
- CS-1581;SBI-0206965;SBI-0206965（02）;SBI 0206965;SBI0206965;SBI0206965; SBI-0206965; SBI 0206965.;2-((5-Bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide;SBI-0206965,SBI 0206965,inhibit,Inhibitor,Unc-51 like kinase,Apoptosis,Autophagy,ULK;Benzamide, 2-[[5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]oxy]-N-methyl-
- CBNumber
- CB83039306
- Molecular Formula
- C21H21BrN4O5
- Formula Weight
- 489.32
- MOL File
- 1884220-36-3.mol
SBI-0206965 Property
- Melting point:
- 170 - 172°C
- Density
- 1.434±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 30 mg/ml)
- form
- powder
- pka
- 14.80±0.46(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1540
- Product name
- SBI-0206965
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $159
- Updated
- 2023/06/20
- Product number
- SML1540
- Product name
- SBI-0206965
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $639
- Updated
- 2023/06/20
- Product number
- 18477
- Product name
- SBI-0206965
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 18477
- Product name
- SBI-0206965
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- 18477
- Product name
- SBI-0206965
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $288
- Updated
- 2024/03/01
SBI-0206965 Chemical Properties,Usage,Production
Description
ULK1 is a serine/threonine kinase that acts upstream of phosphatidylinositol 3-kinase (PI3K) to regulate the formation of autophagophores, the precursors of autophagosomes, in response to nutrient deprivation. It is activated by phosphorylation by AMPK and, in turn, phosphorylates and inhibits AMPK. SBI-0206965 is an inhibitor of ULK1 (IC50 = 108 nM) that is less effective against ULK2 (IC50 = 711 nM). It is selective for ULK1 and ULK2 over a panel of 456 additional kinases, showing activity against a few kinases in vitro but not in cells. SBI-0206965 suppresses autophagy induced by mTOR inhibition via AZD 8055 . It also blocks ULK1-dependent cell survival following nutrient deprivation.
Uses
SBI-0206965 is an inhibitor of ULK1. It also blocks ULK1-dependent cell survival following nutrient deprivation. ULK1 is a serine/threonine kinase that acts upstream of phosphatidylinositol 3-kinase (PI3K) to regulate the formation of autophagophores, the precursors of autophagosomes, in response to nutrient deprivation.
Biochem/physiol Actions
Since most of the tumor cells survive on autophagy mechanism, inhibition of autophagy inducers Unc-51 (serine/threonine-protein kinase)-like autophagy activating kinase (ULK1 and ULK2) might be useful in cancer therapy.
References
1) Egan?et al. (2015), Small Molecules Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates; Mol. Cell, 59?285
SBI-0206965 Preparation Products And Raw materials
Raw materials
Preparation Products
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