SBI-0640756

Product Name: SBI-0640756
CAS No.: 1821280-29-8
Chemical Name: SBI-0640756
Synonyms: SBI756;SBI 756;CS-2838;SBI-756;SBI-0640756;SBI-0640756, 10 mM in DMSO;SBI-0640756;SBI 0640756;SBI0640756;SBI 756;SBI756;SBI-756;(E)-6-chloro-3-(3-(5-fluoropyridin-3-yl)acryloyl)-4-phenylquinolin-2(1H)-one;2(1H)-Quinolinone,6-chloro-3-[(2E)-3-(5-fluoro-3-pyridinyl)-1-oxo-2-propen-1-yl]-4-phenyl-;Autophagy,Inhibitor,SBI756,SBI 756,SBI0640756,Eukaryotic Initiation Factor (eIF),inhibit,SBI-0640756
CBNumber: CB43133350
Molecular Formula: C23H14ClFN2O2
Formula Weight: 0
MOL File: Mol file

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SBI-0640756 Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO : ≥ 26 mg/mL (64.23 mM)
form: Solid
color: Light yellow to yellow
InChI: 1S/C23H14ClFN2O2/c24-16-7-8-19-18(11-16)21(15-4-2-1-3-5-15)22(23(29)27-19)20(28)9-6-14-10-17(25)13-26-12-14/h1-13H,(H,27,29)/b9-6+
InChIKey: VVWGPQZBDQVQRC-RMKNXTFCSA-N
SMILES: FC1=CN=CC(/C=C/C(C2=C(C3=CC=CC=C3)C4=C(C=CC(Cl)=C4)NC2=O)=O)=C1

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 40328
Product name: SBI-0640756
Purity: ≥95%
Packaging: 1mg
Price: $28
Updated: 2026/04/30

Cayman Chemical

Product number: 40328
Product name: SBI-0640756
Purity: ≥95%
Packaging: 5mg
Price: $104
Updated: 2026/04/30

Cayman Chemical

Product number: 40328
Product name: SBI-0640756
Purity: ≥95%
Packaging: 10mg
Price: $193
Updated: 2026/04/30

Cayman Chemical

Product number: 40328
Product name: SBI-0640756
Purity: ≥95%
Packaging: 25mg
Price: $447
Updated: 2026/04/30

ChemScene

Product number: CS-5696
Product name: SBI-0640756
Purity: 98.52%
Packaging: 2mg
Price: $132
Updated: 2021/12/16

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SBI-0640756 Chemical Properties,Usage,Production

Uses

SBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex.

Biological Activity

SBI-0640756 is a potent inhibitor of eIF4G1 th at disrupts the eIF4F complex assembly independently of mTOR. SBI-0640756 potently inhibits growth of BRAF-resistant and BRAF-independent melanomas including NRAS- and NF1-mutant melanomas. SBI-0640756 exhibits low toxicity against nontransformed fibroblasts. SBI-0640756 also suppressed AKT and NF-kB signaling.

in vivo

SBI-0640756 (SBI-756) (0.5 mg/kg, i.p.) delays tumor onset and reduces tumor incidence by 50% in Nras^Q61K/Ink4a^–/– genetic model. SBI-0640756 (SBI-756) (1 mg/kg, 2 times per week, i.p.) in combination with BRAF inhibitor potently suppresses growth of established tumors and does not resume tumor growth in immunodeficient mice bearing A375 tumors^[1].

IC 50

eIF4

References

[1] Feng Y et al. SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Res, 2015 Dec 15, 75(24):5211-8. DOI:10.1158/0008-5472.CAN-15-0885

SBI-0640756 Preparation Products And Raw materials

Raw materials

Preparation Products

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SBI-0640756 Suppliers

China 62 India 1 United States 6 Global 69

Shanghai Boyle Chemical Co., Ltd.

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MedChemexpress LLC

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Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghaizehan biopharma technology co., Ltd.

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DebyeTec.com Inc.

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Shanghai YuanYe Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai Chaolan Chemical Technology Center

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Beijing Jin Ming Biotechnology Co., Ltd.

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MQ (shanghai) Pharmaceuticals Co., Ltd.

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1821280-29-8, SBI-0640756Related Search:

SBI-0206965

SBI-0640756

(E)-6-chloro-3-(3-(5-fluoropyridin-3-yl)acryloyl)-4-phenylquinolin-2(1H)-one

CS-2838

SBI 756

SBI-0640756;SBI 0640756;SBI0640756;SBI 756;SBI756;SBI-756

SBI756

SBI-756

2(1H)-Quinolinone,6-chloro-3-[(2E)-3-(5-fluoro-3-pyridinyl)-1-oxo-2-propen-1-yl]-4-phenyl-

Autophagy,Inhibitor,SBI756,SBI 756,SBI0640756,Eukaryotic Initiation Factor (eIF),inhibit,SBI-0640756

SBI-0640756, 10 mM in DMSO

1821280-29-8