ChemicalBook > CAS DataBase List > STF-62247

STF-62247

Product Name
STF-62247
CAS No.
315702-99-9
Chemical Name
STF-62247
Synonyms
ERROR;CS-2363;STF-62247;UV0364770;STF-62247 (STF62247;STF-62247 USP/EP/BP;STF-62247;STF62247;STF 62247;Autophagy Inducer, STF-62247;4-(pyridin-4-yl)-N-m-tolylthiazol-2-amine;N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolaMine
CBNumber
CB82526236
Molecular Formula
C15H13N3S
Formula Weight
267.35
MOL File
315702-99-9.mol
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STF-62247 Property

Melting point:
158-160℃
Density 
1.255
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO: soluble26mg/mL
form 
solid
color 
Off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26-39
WGK Germany 
2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S7448
Product name
STF-62247
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$172
Updated
2024/03/01
Sigma-Aldrich
Product number
189497
Product name
Autophagy Inducer, STF-62247
Packaging
10mg
Price
$111
Updated
2024/03/01
Cayman Chemical
Product number
13084
Product name
STF-62247
Purity
≥98%
Packaging
5mg
Price
$60
Updated
2024/03/01
Cayman Chemical
Product number
13084
Product name
STF-62247
Purity
≥98%
Packaging
1mg
Price
$19
Updated
2023/06/20
Cayman Chemical
Product number
13084
Product name
STF-62247
Purity
≥98%
Packaging
10mg
Price
$107
Updated
2024/03/01
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STF-62247 Chemical Properties,Usage,Production

Description

STF-62247 (315702-99-9) specifically induces autophagic cell death in VHL (von Hippel-Lindau)-deficient renal carcinoma cells both in vitro (IC50=625 nM) and in vivo. Renal cell carcinoma cell lines were radiosensitized by induction of autophagy following treatment with STF-62247. Cell permeable

Uses

Autophagy Inducer, STF-62247 is selectively kills RCC cells that have lost VHL tumor suppressor activity.

Definition

ChEBI: N-(3-methylphenyl)-4-pyridin-4-yl-2-thiazolamine is a substituted aniline.

in vitro

in vitro study demonstrated that stf-62247 exhibited selectively cytotoxicity and tumor growth inhibitory activity towards wild-type vhl and vhl-deficient renal cell carcinoma (rcc) in a hif-independent manner with ic50 of 16 μm and 0.625 μm, respectively. in addion, stf-62247 also resulted in cell apoptosis by inducing acidification and increasing autophagy in vhl-deficient cells. [1]

in vivo

animal experiments for stf-62247 activity were performed according to institutional and national guidelines and approved by stanford university's administrative panel on laboratory animal care. based on an in vivo mouse model, it was found that intraperitoneal injection of stf-62247 at a dose of 8 mg/kg significantly inhibited tumor growth of vhl-deficient sn12c tumor cells. [1]

IC 50

stf-62247 inhibits tumor growth in wild-type vhl and vhl-deficient renal cell carcinoma (rcc) in a hif-independent manner with ic50 of 16 μm and 0.625 μm, respectively.

References

1) Turcotte et al. (2008), Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death; Autophagy, 4 944 2) Chan et al. (2008), Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics; Cell Cycle, 7 2987 3) Anbalagan et al. (2012), Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy; Radiother. Oncol., 103 388

STF-62247 Preparation Products And Raw materials

Raw materials

Preparation Products

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STF-62247 Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9958
Advantage
58
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
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View Lastest Price from STF-62247 manufacturers

Career Henan Chemical Co
Product
STF-62247 315702-99-9
Price
US $2.00/KG
Min. Order
1g
Purity
98%MIN
Supply Ability
ASK
Release date
2020-01-09

315702-99-9, STF-62247Related Search:


  • STF-62247
  • N-(3-Methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine
  • N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolaMine
  • 4-(pyridin-4-yl)-N-m-tolylthiazol-2-amine
  • Autophagy Inducer, STF-62247
  • ERROR
  • CS-2363
  • STF-62247 (STF62247
  • Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem
  • STF-62247;STF62247;STF 62247
  • N-(3-methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine
  • UV0364770
  • 2-Thiazolamine, N-(3-methylphenyl)-4-(4-pyridinyl)-
  • STF-62247 USP/EP/BP
  • 315702-99-9
  • Inhibitors