STF-62247

ChemicalBook > CAS DataBase List > STF-62247

Product Name: STF-62247
CAS No.: 315702-99-9
Chemical Name: STF-62247
Synonyms: ERROR;CS-2363;STF-62247;UV0364770;STF-62247 (STF62247;STF-62247 USP/EP/BP;STF-62247;STF62247;STF 62247;Autophagy Inducer, STF-62247;4-(pyridin-4-yl)-N-m-tolylthiazol-2-amine;N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolaMine
CBNumber: CB82526236
Molecular Formula: C15H13N3S
Formula Weight: 267.35
MOL File: 315702-99-9.mol

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STF-62247 Property

Melting point:: 158-160℃
Density: 1.255
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO: soluble26mg/mL
form: solid
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26-39
WGK Germany: 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S7448
Product name: STF-62247
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Sigma-Aldrich

Product number: 189497
Product name: Autophagy Inducer, STF-62247
Packaging: 10mg
Price: $111
Updated: 2024/03/01

Cayman Chemical

Product number: 13084
Product name: STF-62247
Purity: ≥98%
Packaging: 5mg
Price: $60
Updated: 2024/03/01

Cayman Chemical

Product number: 13084
Product name: STF-62247
Purity: ≥98%
Packaging: 1mg
Price: $19
Updated: 2023/06/20

Cayman Chemical

Product number: 13084
Product name: STF-62247
Purity: ≥98%
Packaging: 10mg
Price: $107
Updated: 2024/03/01

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STF-62247 Chemical Properties,Usage,Production

Description

STF-62247 (315702-99-9) specifically induces autophagic cell death in VHL (von Hippel-Lindau)-deficient renal carcinoma cells both in vitro (IC50=625 nM) and in vivo. Renal cell carcinoma cell lines were radiosensitized by induction of autophagy following treatment with STF-62247. Cell permeable

Uses

Autophagy Inducer, STF-62247 is selectively kills RCC cells that have lost VHL tumor suppressor activity.

Definition

ChEBI: N-(3-methylphenyl)-4-pyridin-4-yl-2-thiazolamine is a substituted aniline.

in vitro

in vitro study demonstrated that stf-62247 exhibited selectively cytotoxicity and tumor growth inhibitory activity towards wild-type vhl and vhl-deficient renal cell carcinoma (rcc) in a hif-independent manner with ic50 of 16 μm and 0.625 μm, respectively. in addion, stf-62247 also resulted in cell apoptosis by inducing acidification and increasing autophagy in vhl-deficient cells. [1]

in vivo

animal experiments for stf-62247 activity were performed according to institutional and national guidelines and approved by stanford university's administrative panel on laboratory animal care. based on an in vivo mouse model, it was found that intraperitoneal injection of stf-62247 at a dose of 8 mg/kg significantly inhibited tumor growth of vhl-deficient sn12c tumor cells. [1]

IC 50

stf-62247 inhibits tumor growth in wild-type vhl and vhl-deficient renal cell carcinoma (rcc) in a hif-independent manner with ic50 of 16 μm and 0.625 μm, respectively.

References

1) Turcotte et al. (2008), Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death; Autophagy, 4 944 2) Chan et al. (2008), Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics; Cell Cycle, 7 2987 3) Anbalagan et al. (2012), Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy; Radiother. Oncol., 103 388

STF-62247 Preparation Products And Raw materials

Raw materials

Preparation Products

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STF-62247 Suppliers

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View Lastest Price from STF-62247 manufacturers

Career Henan Chemical Co

Product: STF-62247 315702-99-9
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%MIN
Supply Ability: ASK
Release date: 2020-01-09

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STF-62247

N-(3-Methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolaMine

4-(pyridin-4-yl)-N-m-tolylthiazol-2-amine

Autophagy Inducer, STF-62247

ERROR

CS-2363

STF-62247 (STF62247

Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem

STF-62247;STF62247;STF 62247

N-(3-methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine

UV0364770

2-Thiazolamine, N-(3-methylphenyl)-4-(4-pyridinyl)-

STF-62247 USP/EP/BP

315702-99-9

Inhibitors