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YL 0919

Product Name
YL 0919
CAS No.
1339058-04-6
Chemical Name
YL 0919
Synonyms
0919;CS-2407;YL 0919 ，S0282;YL0919 (YL-0919;YL0919 hydrochloride;Hypidone hydrochloride;Hypidone hydrochloride, 10 mM in DMSO;1-((1-Benzyl-4-hydroxypiperidin-4-yl)methyl)pyridin-2(1H)-one hydrochloride;Inhibitor,5-hydroxytryptamine Receptor,Serotonin Receptor,5-HT Receptor,Hypidone,Hypidone hydrochloride,YL 0919,inhibit,YL-0919
CBNumber
CB43148080
Molecular Formula
C18H23ClN2O2
Formula Weight
334.84
MOL File
1339058-04-6.mol
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YL 0919 Property

storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 30 mg/mL (89.60 mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5980
Product name
YL0919
Purity
99.77%
Packaging
2mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-5980
Product name
YL0919
Purity
99.77%
Packaging
5mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-5980
Product name
YL0919
Purity
99.77%
Packaging
10mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-5980
Product name
YL0919
Purity
99.77%
Packaging
25mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-5980
Product name
YL0919
Purity
99.77%
Packaging
50mg
Price
$250
Updated
2021/12/16
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YL 0919 Chemical Properties,Usage,Production

Uses

Hypidone hydrochloride (YL0919) is an orally active antidepressant agent with dual activity as a highly seletive 5-HT uptake blocker and an effective 5-HT1A receptor agonist (Ki=0.19 nM). Hypidone hydrochloride inhibits the uptake of [3H]-5-HT into rat cerebral cortical synaptosomes and HEK293 cells with IC50s of 1.78 nM and 1.93 nM, respectively. Hypidone hydrochloride shows remarkable antidepressant effects in animal models and has the poential for the investigation of depressive disorder[1].

in vivo

Hypidone hydrochloride (YL0919) (oral administration; 1.25 or 5 mg/kg; 4 weeks) and fluoxetine (10 mg/kg) reverses the inhibition of locomotor activity in CUS rats[1].Hypidone hydrochloride (oral administration; 1.25, 2.5, and 5 mg/kg; 4 weeks) significantly reduces the immobility time in TST in mcie FST in mice. Besides, Hypidone hydrochloride displays no effect on the locomotor activity in a separate OFT. Furthermore, the antidepressant-like effect of Hypidone hydrochloride in TST and FST is completely bunted by coadministration with WAY-100635[1].

Animal Model:Male ICR mice weighing 18–22 g[1]
Dosage:1.25, 2.5, and 5 mg/kg
Administration:Oral administration
Result:Had an effect on Antidepressant-like mice in TST and FST.

IC 50

5-HT1A Receptor

References

[1] Chen, H. X. et al. Antidepressant-like activity of YL-0919: a novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist. PloS one 8, e83271, doi:10.1371/journal.pone.0083271 (2013). DOI:10.1371/journal.pone.0083271
[2] Qin, J. J. et al. The role of activation of the 5-HT1A receptor and adenylate cyclase in the antidepressant-like effect of YL-0919, a dual 5-HT1A agonist and selective serotonin reuptake inhibitor. Neuroscience letters 582, 104-108, 2014.09.009 (2014)

YL 0919 Preparation Products And Raw materials

Raw materials

Preparation Products

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YL 0919 Suppliers

China 48 India 1 United States 6 Global 55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12476
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3276
Advantage
58
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View Lastest Price from YL 0919 manufacturers

Career Henan Chemical Co
Product
YL 0919 1339058-04-6
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

1339058-04-6, YL 0919Related Search:

YKL-5-124 yk11 YK-4-279 YKL 06-061 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE

  • YL0919 hydrochloride
  • CS-2407
  • YL0919 (YL-0919
  • 0919
  • Hypidone hydrochloride
  • Inhibitor,5-hydroxytryptamine Receptor,Serotonin Receptor,5-HT Receptor,Hypidone,Hypidone hydrochloride,YL 0919,inhibit,YL-0919
  • 1-((1-Benzyl-4-hydroxypiperidin-4-yl)methyl)pyridin-2(1H)-one hydrochloride
  • Hypidone hydrochloride, 10 mM in DMSO
  • YL 0919 ，S0282
  • 1339058-04-6