yk11
- Product Name
- yk11
- CAS No.
- 1370003-76-1
- Chemical Name
- yk11
- Synonyms
- yk1;YK-ll;YK-11-OA;Hot sell;YK11;YK 11;sarms YK11;yk11/mk677;YK-11 powder;YK11-1 gram(44);YK11 White Powder
- CBNumber
- CB73055372
- Molecular Formula
- C25H34O6
- Formula Weight
- 430.53
- MOL File
- 1370003-76-1.mol
yk11 Property
- Melting point:
- 134-137°C
- Boiling point:
- 564.4±50.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Pale Yellow
- InChI
- InChI=1S/C25H34O6/c1-23-11-9-18-17-8-6-16(26)13-15(17)5-7-19(18)20(23)10-12-25(23)21(14-22(27)28-3)30-24(2,29-4)31-25/h13-14,17-20H,5-12H2,1-4H3/b21-14+/t17-,18+,19+,20-,23-,24?,25+/m0/s1
- InChIKey
- KCQHQCDHFVGNMK-PQUNLUOYSA-N
- SMILES
- O1C(C([H])([H])[H])(OC([H])([H])[H])O/C(=C(\[H])/C(=O)OC([H])([H])[H])/[C@]21C([H])([H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(C([H])([H])C([H])([H])[C@]4([H])[C@@]3([H])C([H])([H])C([H])([H])[C@@]12C([H])([H])[H])=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child
H370Causes damage to organs
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 9003137
- Product name
- YK-11
- Packaging
- 10mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 9003137
- Product name
- YK-11
- Packaging
- 100mg
- Price
- $263
- Updated
- 2024/03/01
- Product number
- 9003137
- Product name
- YK-11
- Packaging
- 50mg
- Price
- $156
- Updated
- 2024/03/01
- Product number
- Y120025
- Product name
- YK-11(Mixtureofdiasteromers)
- Packaging
- 50mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- DC10809
- Product name
- YK-11
- Purity
- >98%
- Packaging
- 100mg
- Price
- $450
- Updated
- 2021/12/16
yk11 Chemical Properties,Usage,Production
Description
YK11 was first studied by Japanese researcher Yuichiro Kanno in 2011. It was found to be a partial agonist of the androgen receptor (AR), genetically selective, leading researchers to believe the compound was a SARM. YK11 is an experimental drug candidate and an unapproved substance for use in humans.
Uses
YK-11 is a synthetic steroidal selective androgen receptor modulator (SARM).It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce the physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the AR.
Mechanism of action
YK-11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM.1 It induces expression of the androgen receptor target genes FKBP51 and FGF18 in HEK293 cells when used at a concentration of 10 μM. YK-11 accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini. In C2C12 cells, YK-11 (500 nM) increases expression of the myogenic regulatory factors MyoD, Myf5, and myogenin, as well as follistatin (Fst), and induces myogenic differentiation.
References
[1] Yuichiro Kanno, et al. Exp Cell Res. Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells DOI:10.1016/j.yexcr.2022.113333
[2] Su Jin Lee, et al. Biochem Biophys Res Commun. Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis DOI:10.1016/j.bbrc.2021.01.030
[3] Tomofumi Yatsu, et al. Biol Pharm Bull. Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells DOI:10.1248/bpb.b17-00748
[4] Mario Thevis, et al. Mol Cell Endocrinol. Detection of SARMs in doping control analysis DOI:10.1016/j.mce.2017.01.040
[5] Yuichiro Kanno, et al. Biol Pharm Bull. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression DOI:10.1248/BPB.B13-00231
yk11 Preparation Products And Raw materials
Raw materials
Preparation Products
yk11 Suppliers
- Tel
- 027-87607080 13433334465
- 396587392@qq.com
- Country
- China
- ProdList
- 347
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- 58
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- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
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- China
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- 021-61984905-1 18016477331
- synchempharma@aliyun.com
- Country
- China
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- 55
- Tel
- 16314854226
- info@bocsci.com
- Country
- United States
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- 9926
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- 65
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- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
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- China
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- 58
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- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9934
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- 55
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- 18872289958、027-52304252、3400508168
- Fax
- 027-52304252
- 3400508168@qq.com
- Country
- China
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- 1910
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- 55
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- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
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- 4662
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- Tel
- admin@ws-biology.hzqiye.ntesmail.com
- Country
- China
- ProdList
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- Tel
- 0576-88813233 13396860566
- sales@pharm-intermediates.com
- Country
- China
- ProdList
- 2013
- Advantage
- 58
View Lastest Price from yk11 manufacturers
- Product
- YK-11 1370003-76-1
- Price
- US $90.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 1000
- Release date
- 2024-03-21
- Product
- yk11 1370003-76-1
- Price
- US $1.00-1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2024-03-26
- Product
- YK11 1370003-76-1
- Price
- US $9.90-17339.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 25kg
- Release date
- 2023-03-30