yk11

ChemicalBook > CAS DataBase List > yk11

Product Name: yk11
CAS No.: 1370003-76-1
Chemical Name: yk11
Synonyms: yk1;YK-ll;YK-11-OA;Hot sell;YK11;YK 11;sarms YK11;yk11/mk677;YK-11 powder;YK11-1 gram(44);YK11 White Powder
CBNumber: CB73055372
Molecular Formula: C25H34O6
Formula Weight: 430.53
MOL File: 1370003-76-1.mol

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yk11 Property

Melting point:: 134-137°C
Boiling point:: 564.4±50.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White to Pale Yellow
InChI: InChI=1S/C25H34O6/c1-23-11-9-18-17-8-6-16(26)13-15(17)5-7-19(18)20(23)10-12-25(23)21(14-22(27)28-3)30-24(2,29-4)31-25/h13-14,17-20H,5-12H2,1-4H3/b21-14+/t17-,18+,19+,20-,23-,24?,25+/m0/s1
InChIKey: KCQHQCDHFVGNMK-PQUNLUOYSA-N
SMILES: O1C(C([H])([H])[H])(OC([H])([H])[H])O/C(=C(\[H])/C(=O)OC([H])([H])[H])/[C@]21C([H])([H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(C([H])([H])C([H])([H])[C@]4([H])[C@@]3([H])C([H])([H])C([H])([H])[C@@]12C([H])([H])[H])=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H341Suspected of causing genetic defects

H361Suspected of damaging fertility or the unborn child

H370Causes damage to organs

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 9003137
Product name: YK-11
Packaging: 10mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 9003137
Product name: YK-11
Packaging: 100mg
Price: $263
Updated: 2024/03/01

Cayman Chemical

Product number: 9003137
Product name: YK-11
Packaging: 50mg
Price: $156
Updated: 2024/03/01

TRC

Product number: Y120025
Product name: YK-11(Mixtureofdiasteromers)
Packaging: 50mg
Price: $175
Updated: 2021/12/16

DC Chemicals

Product number: DC10809
Product name: YK-11
Purity: >98%
Packaging: 100mg
Price: $450
Updated: 2021/12/16

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yk11 Chemical Properties,Usage,Production

Description

YK11 was first studied by Japanese researcher Yuichiro Kanno in 2011. It was found to be a partial agonist of the androgen receptor (AR), genetically selective, leading researchers to believe the compound was a SARM. YK11 is an experimental drug candidate and an unapproved substance for use in humans.

Uses

YK-11 is a synthetic steroidal selective androgen receptor modulator (SARM).It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce the physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the AR.

Mechanism of action

YK-11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM.1 It induces expression of the androgen receptor target genes FKBP51 and FGF18 in HEK293 cells when used at a concentration of 10 μM. YK-11 accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini. In C2C12 cells, YK-11 (500 nM) increases expression of the myogenic regulatory factors MyoD, Myf5, and myogenin, as well as follistatin (Fst), and induces myogenic differentiation.

References

[1] Yuichiro Kanno, et al. Exp Cell Res. Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells DOI:10.1016/j.yexcr.2022.113333
[2] Su Jin Lee, et al. Biochem Biophys Res Commun. Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis DOI:10.1016/j.bbrc.2021.01.030
[3] Tomofumi Yatsu, et al. Biol Pharm Bull. Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells DOI:10.1248/bpb.b17-00748
[4] Mario Thevis, et al. Mol Cell Endocrinol. Detection of SARMs in doping control analysis DOI:10.1016/j.mce.2017.01.040
[5] Yuichiro Kanno, et al. Biol Pharm Bull. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression DOI:10.1248/BPB.B13-00231

yk11 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from yk11 manufacturers

Wuhan Cell Pharmaceutical Co., Ltd

Product: YK11 1370003-76-1
Price: US $9.90-17339.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 25kg
Release date: 2023-03-30

hebei hongtan Biotechnology Co., Ltd

Product: YK-11 1370003-76-1
Price: US $90.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 1000
Release date: 2024-03-21

Dorne Chemical Technology co. LTD

Product: yk11 1370003-76-1
Price: US $1.00-1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

1370003-76-1, yk11Related Search:

YK11 YKL-5-124 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE YKL 06-061 YL 0919 YK-3-237 YK-4-279

YK-11-OA

(17alpha,20E)-17,20-[(1-Methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester

YK11 YK11 white powder

High quality 1370003-76-1 Sarms YK11 CAS NO.1370003-76-1 Manufacturers wholesale

YK11;YK 11

Factory supply with low price Sarms YK11 99% YK-11 in stock CAS NO.1370003-76-1

YK-11 (Mixture of diasteromers)

Hot sell

yk1

19-Norpregna-4,20-diene-21-carboxylic acid, 17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-, methyl ester, (17α,20E)-

free samples sarms YK11

sarms YK11

Sarms Yk 11 Powder

(17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-Norpregna-4,20-diene-21-carboxylic acid, methyl ester

Pharmaceutical Grade YK-11

YK11 White Powder

yk11/mk677

YK-11 powder

Methyl (2E)-2-[(8R,9S,10R,13S,14S,17S)-2'-methoxy-2',13-dimethyl-3-oxospiro[1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,5'-1,3-dioxolane]-4'-ylidene]acetate

YK11-1 gram(44)

YK-ll

1370003-76-1