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2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE

Product Name
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
CAS No.
36341-25-0
Chemical Name
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
Synonyms
Y109;Y-109;YL-109;Y-109;Y109;Phenol, 4-(2-benzothiazolyl)-2-methoxy-;4-(benzo[d]thiazol-2-yl)-2-Methoxyphenol;4-(1,3-Benzothiazol-2-yl)-2-methoxyphenol;2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE;4-(3H-1,3-benzothiazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one;inhibit,aryl,YL 109,hydrocarbon,AhR,antitumor,Aryl Hydrocarbon Receptor,YL109,carboxyl,breast,Hsp70-interacting,CHIP,protein,AhR,cancer,YL-109,terminus,invasiveness,Inhibitor
CBNumber
CB61477104
Molecular Formula
C14H11NO2S
Formula Weight
257.31
MOL File
36341-25-0.mol
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2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Property

storage temp. 
2-8°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml; Ethanol: 1 mg/ml
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30290
Product name
YL-109
Packaging
5mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
30290
Product name
YL-109
Packaging
50mg
Price
$380
Updated
2024/03/01
Cayman Chemical
Product number
30290
Product name
YL-109
Packaging
10mg
Price
$195
Updated
2024/03/01
Cayman Chemical
Product number
30290
Product name
YL-109
Packaging
25mg
Price
$352
Updated
2024/03/01
AK Scientific
Product number
3261AH
Product name
4-(Benzo[D]thiazol-2-yl)-2-methoxyphenol
Packaging
1g
Price
$520
Updated
2021/12/16
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2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Chemical Properties,Usage,Production

Biological Activity

YL-109 is a novel antitumor agent that inhibits the growth and invasion of breast cancer cells in vitro and in vivo.

in vitro

YL-109 (0.001-10 μM; 96 h or 24 h) inhibits cell proliferation, motility, and invasiveness in breast cancer cells.
YL-109 (1 μM) increases both CHIP mRNA and protein levels in MDA-MB-231 cells.

Cell Proliferation Assay

< td class="col2"> MCF-7 and MDA-MB-231 cells
Cell Line:
Concentration: 0.001, 0.01, 0.1, 1, 10 μM
Incubation Time: 96 hours
Result: Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50 =85.8 nM and 4.02 μM, respectively).

in vivo

YL-109 (15 mg/kg; sc for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo.

< /p>

Animal Model: BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells
Dosage: 15 mg/kg
Administration: < /td> Sc every 2 days for 63 days
Result: Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells.

2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Suppliers

China 44 India 1 United States 11 Global 56
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
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China
ProdList
19918
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Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
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61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
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58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
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Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
18122150900
Fax
QQ:2869377561
Email
sculk28@163.com
Country
China
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647
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Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
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China
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3868
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58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
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Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
info@SuperLan-chem.com
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China
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9445
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Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
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58
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
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36341-25-0, 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLERelated Search:

YKL-5-124 yk11 YK-4-279 YKL 06-061 YL 0919

  • 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
  • YL-109
  • 4-(benzo[d]thiazol-2-yl)-2-Methoxyphenol
  • Y109
  • Y-109
  • Y-109;Y109
  • 4-(3H-1,3-benzothiazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one
  • 4-(1,3-Benzothiazol-2-yl)-2-methoxyphenol
  • Phenol, 4-(2-benzothiazolyl)-2-methoxy-
  • inhibit,aryl,YL 109,hydrocarbon,AhR,antitumor,Aryl Hydrocarbon Receptor,YL109,carboxyl,breast,Hsp70-interacting,CHIP,protein,AhR,cancer,YL-109,terminus,invasiveness,Inhibitor
  • 36341-25-0
  • Inhibitors