ChemicalBook > CAS DataBase List > 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE

2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE

Product Name
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
CAS No.
36341-25-0
Chemical Name
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
Synonyms
Y109;Y-109;YL-109;Y-109;Y109;Phenol, 4-(2-benzothiazolyl)-2-methoxy-;4-(benzo[d]thiazol-2-yl)-2-Methoxyphenol;4-(1,3-Benzothiazol-2-yl)-2-methoxyphenol;2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE;4-(3H-1,3-benzothiazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one;inhibit,aryl,YL 109,hydrocarbon,AhR,antitumor,Aryl Hydrocarbon Receptor,YL109,carboxyl,breast,Hsp70-interacting,CHIP,protein,AhR,cancer,YL-109,terminus,invasiveness,Inhibitor
CBNumber
CB61477104
Molecular Formula
C14H11NO2S
Formula Weight
257.31
MOL File
36341-25-0.mol
More
Less

2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Property

storage temp. 
2-8°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml; Ethanol: 1 mg/ml
form 
A crystalline solid
color 
Light yellow to yellow
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
30290
Product name
YL-109
Packaging
5mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
30290
Product name
YL-109
Packaging
50mg
Price
$380
Updated
2024/03/01
Cayman Chemical
Product number
30290
Product name
YL-109
Packaging
10mg
Price
$195
Updated
2024/03/01
Cayman Chemical
Product number
30290
Product name
YL-109
Packaging
25mg
Price
$352
Updated
2024/03/01
AK Scientific
Product number
3261AH
Product name
4-(Benzo[D]thiazol-2-yl)-2-methoxyphenol
Packaging
1g
Price
$520
Updated
2021/12/16
More
Less

2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Chemical Properties,Usage,Production

Biological Activity

YL-109 is a novel antitumor agent that inhibits the growth and invasion of breast cancer cells in vitro and in vivo.

in vitro

YL-109 (0.001-10 μM; 96 h or 24 h) inhibits cell proliferation, motility, and invasiveness in breast cancer cells.
YL-109 (1 μM) increases both CHIP mRNA and protein levels in MDA-MB-231 cells.

Cell Proliferation Assay

< td class="col2"> MCF-7 and MDA-MB-231 cells
Cell Line:
Concentration: 0.001, 0.01, 0.1, 1, 10 μM
Incubation Time: 96 hours
Result: Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50 =85.8 nM and 4.02 μM, respectively).

in vivo

YL-109 (15 mg/kg; sc for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo.

< /p>

Animal Model: BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells
Dosage: 15 mg/kg
Administration: < /td> Sc every 2 days for 63 days
Result: Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells.

2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Suppliers

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
18122150900
Fax
QQ:2869377561
Email
sculk28@163.com
Country
China
ProdList
646
Advantage
55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
4966
Advantage
55
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ:65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7296
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58

36341-25-0, 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLERelated Search:


  • 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
  • YL-109
  • 4-(benzo[d]thiazol-2-yl)-2-Methoxyphenol
  • Y109
  • Y-109
  • Y-109;Y109
  • 4-(3H-1,3-benzothiazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one
  • 4-(1,3-Benzothiazol-2-yl)-2-methoxyphenol
  • Phenol, 4-(2-benzothiazolyl)-2-methoxy-
  • inhibit,aryl,YL 109,hydrocarbon,AhR,antitumor,Aryl Hydrocarbon Receptor,YL109,carboxyl,breast,Hsp70-interacting,CHIP,protein,AhR,cancer,YL-109,terminus,invasiveness,Inhibitor
  • 36341-25-0
  • Inhibitors