ChemicalBook > CAS DataBase List > 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
- Product Name
- 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
- CAS No.
- 36341-25-0
- Chemical Name
- 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
- Synonyms
- Y109;Y-109;YL-109;Y-109;Y109;Phenol, 4-(2-benzothiazolyl)-2-methoxy-;4-(benzo[d]thiazol-2-yl)-2-Methoxyphenol;4-(1,3-Benzothiazol-2-yl)-2-methoxyphenol;2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE;4-(3H-1,3-benzothiazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one;inhibit,aryl,YL 109,hydrocarbon,AhR,antitumor,Aryl Hydrocarbon Receptor,YL109,carboxyl,breast,Hsp70-interacting,CHIP,protein,AhR,cancer,YL-109,terminus,invasiveness,Inhibitor
- CBNumber
- CB61477104
- Molecular Formula
- C14H11NO2S
- Formula Weight
- 257.31
- MOL File
- 36341-25-0.mol
More
Less
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Property
- storage temp.
- 2-8°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml; Ethanol: 1 mg/ml
- form
- A crystalline solid
- color
- Light yellow to yellow
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 30290
- Product name
- YL-109
- Packaging
- 5mg
- Price
- $110
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30290
- Product name
- YL-109
- Packaging
- 50mg
- Price
- $380
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30290
- Product name
- YL-109
- Packaging
- 10mg
- Price
- $195
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30290
- Product name
- YL-109
- Packaging
- 25mg
- Price
- $352
- Updated
- 2024/03/01
AK Scientific
- Product number
- 3261AH
- Product name
- 4-(Benzo[D]thiazol-2-yl)-2-methoxyphenol
- Packaging
- 1g
- Price
- $520
- Updated
- 2021/12/16
More
Less
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Chemical Properties,Usage,Production
Biological Activity
YL-109 is a novel antitumor agent that inhibits the growth and invasion of breast cancer cells in vitro and in vivo.
in vitro
YL-109 (0.001-10 μM; 96 h or 24 h) inhibits cell proliferation, motility, and invasiveness in breast cancer cells.
YL-109 (1 μM) increases both CHIP mRNA and protein levels in MDA-MB-231 cells.
Cell Proliferation Assay
| Cell Line: | < td class="col2"> MCF-7 and MDA-MB-231 cells|
| Concentration: | 0.001, 0.01, 0.1, 1, 10 μM |
| Incubation Time: | 96 hours |
| Result: | Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50 =85.8 nM and 4.02 μM, respectively). |
in vivo
YL-109 (15 mg/kg; sc for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo.
< /p>
| Animal Model: | BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells |
| Dosage: | 15 mg/kg |
| Administration: < /td> | Sc every 2 days for 63 days |
| Result: | Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells. |
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58