ChemicalBook > CAS DataBase List > 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE

2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE

Product Name
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
CAS No.
36341-25-0
Chemical Name
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
Synonyms
Y109;Y-109;YL-109;Y-109;Y109;Phenol, 4-(2-benzothiazolyl)-2-methoxy-;4-(benzo[d]thiazol-2-yl)-2-Methoxyphenol;4-(1,3-Benzothiazol-2-yl)-2-methoxyphenol;2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE;4-(3H-1,3-benzothiazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one;inhibit,aryl,YL 109,hydrocarbon,AhR,antitumor,Aryl Hydrocarbon Receptor,YL109,carboxyl,breast,Hsp70-interacting,CHIP,protein,AhR,cancer,YL-109,terminus,invasiveness,Inhibitor
CBNumber
CB61477104
Molecular Formula
C14H11NO2S
Formula Weight
257.31
MOL File
36341-25-0.mol
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2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Property

storage temp. 
2-8°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml; Ethanol: 1 mg/ml
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30290
Product name
YL-109
Packaging
5mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
30290
Product name
YL-109
Packaging
50mg
Price
$380
Updated
2024/03/01
Cayman Chemical
Product number
30290
Product name
YL-109
Packaging
10mg
Price
$195
Updated
2024/03/01
Cayman Chemical
Product number
30290
Product name
YL-109
Packaging
25mg
Price
$352
Updated
2024/03/01
AK Scientific
Product number
3261AH
Product name
4-(Benzo[D]thiazol-2-yl)-2-methoxyphenol
Packaging
1g
Price
$520
Updated
2021/12/16
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2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Chemical Properties,Usage,Production

Biological Activity

YL-109 is a novel antitumor agent that inhibits the growth and invasion of breast cancer cells in vitro and in vivo.

in vitro

YL-109 (0.001-10 μM; 96 h or 24 h) inhibits cell proliferation, motility, and invasiveness in breast cancer cells.
YL-109 (1 μM) increases both CHIP mRNA and protein levels in MDA-MB-231 cells.

Cell Proliferation Assay

< td class="col2"> MCF-7 and MDA-MB-231 cells
Cell Line:
Concentration: 0.001, 0.01, 0.1, 1, 10 μM
Incubation Time: 96 hours
Result: Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50 =85.8 nM and 4.02 μM, respectively).

in vivo

YL-109 (15 mg/kg; sc for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo.

< /p>

Animal Model: BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells
Dosage: 15 mg/kg
Administration: < /td> Sc every 2 days for 63 days
Result: Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells.

2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE Suppliers

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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36341-25-0, 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLERelated Search:

YKL-5-124 yk11 YK-4-279 YKL 06-061 YL 0919

  • 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
  • YL-109
  • 4-(benzo[d]thiazol-2-yl)-2-Methoxyphenol
  • Y109
  • Y-109
  • Y-109;Y109
  • 4-(3H-1,3-benzothiazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one
  • 4-(1,3-Benzothiazol-2-yl)-2-methoxyphenol
  • Phenol, 4-(2-benzothiazolyl)-2-methoxy-
  • inhibit,aryl,YL 109,hydrocarbon,AhR,antitumor,Aryl Hydrocarbon Receptor,YL109,carboxyl,breast,Hsp70-interacting,CHIP,protein,AhR,cancer,YL-109,terminus,invasiveness,Inhibitor
  • 36341-25-0
  • Inhibitors