Fezolinetant
- Product Name
- Fezolinetant
- CAS No.
- 1629229-37-3
- Chemical Name
- Fezolinetant
- Synonyms
- ESN-364;Fezolinetant;Fexolinetant;Non zolpidem;Fezolinetant, 10 mM in DMSO;FEZOLINETANT; ESN-364; ESN 364; ESN364;(S)-1-((2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-2,3-dihydro-1H-indene-4-carbonitrile;Inhibitor,Neurokinin Receptor,ESN364,Tachykinin receptor,ESN 364,Fezolinetant,inhibit,NK receptor;(R)-(4-fluorophenyl)(8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone;Methanone, [(8R)-5,6-dihydro-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl](4-fluorophenyl)-
- CBNumber
- CB43159873
- Molecular Formula
- C16H15FN6OS
- Formula Weight
- 358.39
- MOL File
- 1629229-37-3.mol
Fezolinetant Property
- Boiling point:
- 623.0±65.0 °C(Predicted)
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:20.0(Max Conc. mg/mL);55.8(Max Conc. mM)
- pka
- -0.28±0.40(Predicted)
- form
- Solid
- color
- White to yellow
- InChI
- InChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1
- InChIKey
- PPSNFPASKFYPMN-SECBINFHSA-N
- SMILES
- C(N1CCN2C(C3SN=C(C)N=3)=NN=C2[C@H]1C)(C1=CC=C(F)C=C1)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 39523
- Product name
- Fezolinetant
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $112
- Updated
- 2026/04/30
- Product number
- 39523
- Product name
- Fezolinetant
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $212
- Updated
- 2026/04/30
- Product number
- 39523
- Product name
- Fezolinetant
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $501
- Updated
- 2026/04/30
- Product number
- 39523
- Product name
- Fezolinetant
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $945
- Updated
- 2026/04/30
- Product number
- CS-7952
- Product name
- Fezolinetant
- Purity
- 98.16%
- Packaging
- 25mg
- Price
- $1140
- Updated
- 2021/12/16
Fezolinetant Chemical Properties,Usage,Production
Uses
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.
Definition
ChEBI: Fezolinetant is a triazolopyrazine that is 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine substituted by 3-methyl-1,2,4-thiadiazol-5-yl, 4-fluorobenzoyl and methyl groups at positions 3, 7, and 8R, respectively. It is a prescription medicine used to reduce moderate to severe vasomotor symptoms due to menopause. It has a role as a neurokinin-3 receptor antagonist. It is a member of monofluorobenzenes, a triazolopyrazine, a member of thiadiazoles, a member of benzamides and a tertiary carboxamide.
Mechanism of action
Fezolinetant is an oral non-hormonal therapy that is an NK3R antagonist. It works by binding to and blocking the activity of NK3 receptors, which play a role in the regulation of body temperature in the brain.
Side effects
The common side effects of Fezolinetant include abdominal pain, diarrhoea, insomnia, back pain, hot flushes and elevated liver transaminases.
in vivo
Fezolinetant (ESN364, 1 mg/kg, iv bolus) reversibly inhibits the regular, pulsatile secretion of LH in the ovarectomized ewe. ESN364 represses the pulse pattern of LH in all treated animals. ESN364 (5 mg/kg, p.o.) lowers plasma LH, but not FSH, in the castrated monkey. ESN364 (10, 25, 50 mg/kg, orally) also blocks the LH surge and decreases ovarian hormone levels throughout the menstrual cycle in monkeys[1].
IC 50
NK3
Fezolinetant Preparation Products And Raw materials
Raw materials
Preparation Products
Fezolinetant Suppliers
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View Lastest Price from Fezolinetant manufacturers
- Product
- Fezolinetant 1629229-37-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-07
- Product
- Fezolinetant 1629229-37-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 100
- Release date
- 2024-08-13
- Product
- Fezolinetant 1629229-37-3
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 50kg/Month
- Release date
- 2024-07-03