FIN56
- Product Name
- FIN56
- CAS No.
- 1083162-61-1
- Chemical Name
- FIN56
- Synonyms
- FIN56;FIN-56;FIN 56;FIN56 >=98% (HPLC);FIN56;FIN-56 ;FIN 56;N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide;9H-Fluorene-2,7-disulfonamide, N2,N7-dicyclohexyl-9-(hydroxyimino)-;FIN56 N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide;inhibit,GPX4,FIN56,Ferroptosis,degradation,FIN 56,Inhibitor,squalene,synthase,FIN-56
- CBNumber
- CB43160424
- Molecular Formula
- C25H31N3O5S2
- Formula Weight
- 517.66
- MOL File
- 1083162-61-1.mol
FIN56 Property
- Boiling point:
- 759.1±70.0 °C(Predicted)
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- Soluble in DMSO (>25 mg/ml)
- form
- powder
- pka
- 10.10±0.20(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
N-Bromosuccinimide Price
- Product number
- SML1740
- Product name
- FIN56
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $107
- Updated
- 2023/06/20
- Product number
- SML1740
- Product name
- FIN56
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $434
- Updated
- 2023/06/20
- Product number
- 25180
- Product name
- FIN56
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $67
- Updated
- 2024/03/01
- Product number
- 25180
- Product name
- FIN56
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 25180
- Product name
- FIN56
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $249
- Updated
- 2024/03/01
FIN56 Chemical Properties,Usage,Production
Description
FIN56 (1083162-61-1) is a novel inducer of ferroptosis acting via degradation of GPX4 and activation of squalene synthase (leading to CoQ10 depletion, a compound which inhibits ferroptosis via an unknown mechanism).1? FIN56 inhibited glioblastoma growth in vitro and in vivo via induction of ferroptosis as well as lysosomal membrane permeabilization.2
Definition
ChEBI: FIN56 is a fluorene that is N-9H-fluoren-9-ylidenehydroxylamine substituted by N-cyclohexylsulfonyl groups at positions 2 and 7. It induces ferroptosis via degradation of GPX4 and also binds and activates squalene synthase. It has a role as a ferroptosis inducer and an EC 1.11.1.9 (glutathione peroxidase) inhibitor. It is a member of fluorenes, a ketoxime and a sulfonamide. It is functionally related to a 9-hydroxyiminofluorene-2,7-disulfonamide.
Biochem/physiol Actions
Ferroptosis inducer 56 (FIN56) is a member of the class 3 ferroptosis inducers.
storage
Store at +4°C
References
Shimada et al. (2016), Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis; Chem. Biol. 12 497 Zhang et al. (2021), FIN56, a novel ferroptosis inducer, triggers lysosomal membrane permeabilization in a TFEB-dependent manner in glioblastoma; Cancer 12 6610
FIN56 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from FIN56 manufacturers
- Product
- FIN56 1083162-61-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23