ChemicalBook > CAS DataBase List > N-desalkylflurazepam

N-desalkylflurazepam

Product Name
N-desalkylflurazepam
CAS No.
2886-65-9
Chemical Name
N-desalkylflurazepam
Synonyms
DESALKYLFLURAZEPAM;NORFLUDIAZEPAM;N-desallkylflurazepam;FlurazepaM Related CoMpound F;cm7116;ro5-3367;sch17514;MMK1 TFA;RO 5-3367;nor-Flurazepam
CBNumber
CB4316060
Molecular Formula
C15H10ClFN2O
Formula Weight
288.7
MOL File
2886-65-9.mol
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N-desalkylflurazepam Property

Melting point:
204-206°C
Boiling point:
454.0±45.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
Flash point:
9℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
A neat solid
pka
11.55±0.70(Predicted)
InChI
InChI=1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
InChIKey
UVCOILFBWYKHHB-UHFFFAOYSA-N
SMILES
N1C2=CC=C(Cl)C=C2C(C2=CC=CC=C2F)=NCC1=O
CAS DataBase Reference
2886-65-9(CAS DataBase Reference)
NIST Chemistry Reference
Norfludiazepam(2886-65-9)
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
22-24/25-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
2
RTECS 
DF2370100
HS Code 
2933997500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H336May cause drowsiness or dizziness

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D-915
Product name
Desalkylflurazepam solution
Purity
1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$46.6
Updated
2024/03/01
Sigma-Aldrich
Product number
BP730
Product name
N-Desalkylflurazepam
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
25MG
Price
$222
Updated
2024/03/01
Sigma-Aldrich
Product number
1285603
Product name
Flurazepam Related Compound F
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$456
Updated
2024/03/01
Cayman Chemical
Product number
18484
Product name
Desalkylflurazepam
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18484
Product name
Desalkylflurazepam
Purity
≥98%
Packaging
5mg
Price
$145
Updated
2024/03/01
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N-desalkylflurazepam Chemical Properties,Usage,Production

Description

Desalkylflurazepam (Item No. 18484) is an analytical reference material that is structurally categorized as a benzodiazepine. It is an active metabolite of several benzodiazepines, including flurazepam , flutoprazepam, fludiazepam, midazolam, and quazepam. Desalkylflurazepam inhibits L-type voltage-gated calcium channels (Cav; IC50s = 55 and 37 μM for Cav1.2 and 1.3, respectively) by positively modulating GABAA receptors. It can be detected in urine, serum, and meconium by LC-MS/MS. This product is intended for research and forensic applications.

Chemical Properties

Light Yellow Solid

Uses

The major human metabolite of flurazepam. This is a controlled drug precursor therefore a liscence may be required for purchase

Definition

ChEBI: Desalkylflurazepam is a benzodiazepine.

General Description

N-Desalkylflurazepam (also known as norflurazepam, 2886-65-9) is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.

Mode of action

N-Desalkylflurazepam is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.

N-desalkylflurazepam Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-desalkylflurazepam manufacturers

Dorne Chemical Technology co. LTD
Product
NORFLUDIAZEPAM 2886-65-9
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
100kg
Release date
2024-03-26
Anhui Yiao New Material Technology Co., Ltd
Product
norfludiazepam 2886-65-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2023-08-25
Zhejiang Hangyu API Co., Ltd
Product
N-desalkylflurazepam 2886-65-9
Price
US $100.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
100kg
Release date
2023-12-14

2886-65-9, N-desalkylflurazepamRelated Search:

CHLOROPHENYLSILANE 97 Hydrochlorothiazide tert-Butylchlorodiphenylsilane Epichlorohydrin PHENYL VALERATE Chlorodimethylphenylsilane DBU Triphenylmethyl Chloride Phenylhydrazine Dihydromyrcenol 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one FLURAZEPAM DIHYDROCHLORIDE Doxefazepam Elfazepam Chloroacetic acid Proflazepam Difluorochloromethane Fludiazepam

  • NORFLUDIAZEPAM
  • Dealkylflurazepam
  • Descarbethoxyloflazepate
  • Flurazepam M (des-alkyl)
  • Flurazepam M (N-1-des-alkyl)
  • Flurazepam, des-alkyl
  • N-1-desalkyl-flurazepam
  • N-Desalkyl-2-oxoquazepam
  • N-Desalkylflurazepam
  • N-Desalkylflutoprazepam
  • norflutoprazepam
  • RO 5-3367
  • 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-2h-4-benzodiazepin-2-one
  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-fluorophenyl)-1,3-dihydro-
  • 7-chloro-5-(o-fluorophenyl)-1,3-dihydro-2h-4-benzodiazepin-2-one
  • ro5-3367
  • sch17514
  • DESALKYLFLURAZEPAM
  • Flurazepam Related Compound F Solution, 100ppm
  • Midazolam Impurity F
  • Desalkylflurazepam (CRM)
  • Midazolam Impurity 6(Midazolam EP Impurity F)
  • 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-BENZO[E][1,4]DIAZEPIN-2-ONE
  • 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-1,4-BENZODIAZEPIN-2-ONE
  • 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE
  • 5-(2-FLUOROPHENYL)-7-CHLORO-1,4-BENZODIAZEPIN-2-ONE
  • Midazolam ImpurityⅠ:7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • Flurazepam Hydrochloride ImpurityⅠ：7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • cm7116
  • DESALKYLFLURAZEPAM,100/MLINMETHANOL
  • nor-Flurazepam
  • Flurazepam Related Compound F (50 mg) (7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one)
  • 7-Chloro-5-(2-fluorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
  • FlurazepaM Related CoMpound F
  • 7-chloro-5-(2-fluorophenyl)- 1,4-Benzodiazepin-2-one
  • desalkylflurazepam Solution, 100ppm
  • N-desallkylflurazepam
  • Desalkylflurazepam solution
  • 7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDROXY-4-BENZODIAZEPIN-2-ONE
  • 5-(2-Fluorophenyl)-1,3-dihydro-7-chloro-2H-1,4-benzodiazepin-2-one
  • DESALKYLFLURAZEPAM,1.0MG/MLINMETHANOL
  • 7-CHLORO-5-(2-FLUOROPHENYL)-1,3- DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE 98.0% MIN
  • 2H-1,4-BENZODIAZEIN-2-ONE-7-CHLORO-5-(2-FLUOROPHENYL)-1,3-DIHYDRO
  • 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one
  • 5-(2-Fluorophenyl)-1,3-dihydro-7-chloro-2H-1,4-benzodiazepin-2-oneNorfludiazepam
  • 5-(2-Fluorophenyl)-7-chloro-1,3-dihydro-3H-1,4-benzodiazepin-2-one
  • nor-Flurazepam (1.0 mg/mL in Methanol)
  • Flurazepam Related Compound F(Secondary Standards traceble to USP)
  • TIANFU CHEM 7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • Flurazepam Hydrochloride ImpurityⅠ：7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • Midazolam ImpurityⅠ:7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • Flurazepam Related Compound F (7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one) (1285603)
  • 7-Chloro-5-(2-fluoropheny)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • Flurazepam USP Related Compound F
  • N-Desalkylflurazepam, Norflurazepam
  • Flurazepam-N-desalkyl