Boc-aminooxy-PEG1-Propargyl
- Product Name
- Boc-aminooxy-PEG1-Propargyl
- CAS No.
- 1895922-72-1
- Chemical Name
- Boc-aminooxy-PEG1-Propargyl
- Synonyms
- Boc-aminooxy-PEG1-Propargyl;t-Boc-aminooxy-PEG1-propargyl;Carbamic acid, N-[2-(2-propyn-1-yloxy)ethoxy]-, 1,1-dimethylethyl ester
- CBNumber
- CB43162897
- Molecular Formula
- C10H17NO4
- Formula Weight
- 215.25
- MOL File
- 1895922-72-1.mol
Boc-aminooxy-PEG1-Propargyl Property
- Density
- 1.063±0.06 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
N-Bromosuccinimide Price
- Product number
- BP-23163
- Product name
- t-Boc-aminooxy-PEG1-propargyl
- Purity
- 98%
- Packaging
- 250mg
- Price
- $450
- Updated
- 2021/12/16
Boc-aminooxy-PEG1-Propargyl Chemical Properties,Usage,Production
Description
t-Boc-aminooxy-PEG1-propargyl is a click chemistry PEG linker with a t-Boc-aminooxy group. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The t-Boc aminooxy group can be deprotected under mild acidic conditions and then can react with an aldehyde or ketone group to form a stable oxime linkage. The hydrophilic PEG spacer increases solubility in aqueous media.
Uses
Boc-aminooxy-PEG1-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-aminooxy-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs; Alkyl/ether
References
[1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651
Boc-aminooxy-PEG1-Propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
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