SPDP-PEG8-NHS ester

Product Name: SPDP-PEG8-NHS ester
CAS No.: 1252257-56-9
Chemical Name: SPDP-PEG8-NHS ester
Synonyms: SPDP-dPEG;LC-PEG8-SPDP;SDPD-PEG8-NHS;Opss-peg(8)-nhs;SPDP-dPEG^{®SPDP-PEG8-NHS ester;SPDP-dPEG^{®SPDP-dPEG? 8-NHS ester;SPDP-dPEG(R)8-NHS ester;SPDP-dPEG??-NHS ester (QBD-10376)}}
CBNumber: CB43163142
Molecular Formula: C31H49N3O13S2
Formula Weight: 735.86306
MOL File: 1252257-56-9.mol

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SPDP-PEG8-NHS ester Property

Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: -20°C
form: solid or viscous liquid
pka: 15.01±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: QBD10376
Product name: SPDP-dPEG®8-NHS ester
Packaging: 100MG
Price: $361
Updated: 2025/07/31

Sigma-Aldrich

Product number: QBD10376
Product name: SPDP-dPEG®8-NHS ester
Packaging: 1000MG
Price: $1810
Updated: 2025/07/31

TRC

Product number: O858653
Product name: OPSS-PEG(8)-NHS
Packaging: 1mg
Price: $45
Updated: 2021/12/16

dPEG

Product number: 10376
Product name: SPDP-dPEG®₈-NHSester
Packaging: 100mg
Price: $250
Updated: 2021/12/16

Activate Scientific

Product number: AS107961
Product name: SPDP-dPEG(R)8-NHSester
Purity: 94%
Packaging: 1g
Price: $1885
Updated: 2021/12/16

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SPDP-PEG8-NHS ester Chemical Properties,Usage,Production

Description

SPDP-PEG8-NHS ester is a PEG linker containing an SPDP crosslinker and an NHS ester. The SPDP crosslinker is reactive toward amine and thiol groups and contains a cleavable disulfide bond. This crosslinker is also membrane permeable which allows for intracellular reactions to take place. The NHS ester can react with primary amines to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

Uses

LC-PEG8-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs)[1].

reaction suitability

reactivity: thiol reactive
reagent type: cross-linking reagent
reactivity: amine reactive

IC 50

Disulfide Cleavable Linker; Cleavable Linker

References

[1] Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54(10):3606-23. DOI:10.1021/jm2002958

SPDP-PEG8-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

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SPDP-PEG8-NHS ester Suppliers

China 44 India 1 United States 3 Global 48

Chengdu Pukang Biotechnology Co., Ltd

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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Hunan HuaTeng Pharmaceutical Co., Ltd.,

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Sigma-Aldrich

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Shanghai YuanYe Biotechnology Co., Ltd.

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Beijing Jin Ming Biotechnology Co., Ltd.

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Xi'an Confluore Biological Technology Co., Ltd.

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Alpha Biopharmaceuticals Co., Ltd

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Henan Alpha Chemical Co., Ltd.

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
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View Lastest Price from SPDP-PEG8-NHS ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: SPDP-PEG8-NHS ester 1252257-56-9
Price: US $0.00/mg
Min. Order: 500mg
Purity: >99.00%
Supply Ability: 500mg
Release date: 2024-03-27

1252257-56-9, SPDP-PEG8-NHS esterRelated Search:

SPDP SPDP-PEG2-NHS ester SPDP-PEG9-COOH SPDP-PEG2-COOH PYRIDINE-2-CARBOXAMIDE Polyethylene glycol monolaurate Polyethylene Glycol Nicotinamide Polyethylene glycol monooleate SPDP-PEG8-acid SPDP-PEG4-acid SPDP-PEG4-NHS ester SPDP-dPEG(R)12-NHS ester

SPDP-PEG8-NHS ester

SDPD-PEG8-NHS

SPDP-dPEG(R)8-NHS ester

Opss-peg(8)-nhs

LC-PEG8-SPDP

Propanoic acid, 3-[[25-oxo-27-(2-pyridinyldithio)-3,6,9,12,15,18,21-heptaoxa-24-azaheptacos-1-yl]oxy]-, 2,5-dioxo-1-pyrrolidinyl ester

SPDP-dPEG&reg

SPDP-dPEG&#174

8-NHS ester<img src="/content/dam/sigma-aldrich/head/search/new.png" alt="New" />

SPDP-dPEG

SPDP-dPEG? 8-NHS ester

SPDP-dPEG?8-NHS ester

SPDP-dPEG??-NHS ester (QBD-10376)

1252257-56-9

C31H49N3O13S2

peg