SPDP-PEG4-acid

Product Name: SPDP-PEG4-acid
CAS No.: 581065-97-6
Chemical Name: SPDP-PEG4-acid
Synonyms: SPDP-PEG4-COOH;SDPD-PEG4-COOH;SPDP-PEG4-acid;Opss-peg(4)-cooh;3-Oxo-1-(pyridin-2-yldisulfaneyl)-7,10,13,16-tetraoxa-4-azanonadecan-19-oic acid;Propanoic acid, 3-[[13-oxo-15-(2-pyridinyldithio)-3,6,9-trioxa-12-azapentadec-1-yl]oxy]-
CBNumber: CB03163139
Molecular Formula: C19H30N2O7S2
Formula Weight: 462.5807
MOL File: 581065-97-6.mol

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SPDP-PEG4-acid Property

Boiling point:: 677.3±55.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: 2-8°C, stored under nitrogen
form: Liquid
pka: 4.28±0.10(Predicted)
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-21939
Product name: SPDP-PEG4-acid
Purity: 98%
Packaging: 100mg
Price: $360
Updated: 2021/12/16

BroadPharm

Product number: BP-21939
Product name: SPDP-PEG4-acid
Purity: 98%
Packaging: 500mg
Price: $500
Updated: 2021/12/16

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SPDP-PEG4-acid Chemical Properties,Usage,Production

Description

SPDP-PEG4-acid is a PEG linker containing SPDP crosslinker and carboxylic acid moieties. SPDP is reactive toward thiol groups and contains a cleavable disulfide bond. Its membrane permeability allows for intracellular crosslinking reactions. The terminal caboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic properties of the PEG linkers increase compound solubility in aqueous media.

Uses

SPDP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

SPDP-PEG4-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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SPDP-PEG4-acid Suppliers

China 36 India 1 United States 3 Global 40

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
Fax: 0731-82251112
Email: sales@huatengsci.com
Country: China
ProdList: 5873
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6355
Advantage: 58

Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
Advantage: 58

Alpha Biopharmaceuticals Co., Ltd

Tel: 0411-39042497
Fax: 0411-39042693
Email: sales@alphabiopharm.com
Country: China
ProdList: 1951
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

Nextpeptide Inc

Tel: +86-0571-81612335 +8613336028439
Email: sales@nextpeptide.com
Country: China
ProdList: 19908
Advantage: 58

Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

Tel: 13892832556
Email: 2440688701@qq.com
Country: China
ProdList: 1995
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

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View Lastest Price from SPDP-PEG4-acid manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: SPDP-PEG4-COOH 581065-97-6
Price: US $0.00/mg
Min. Order: 500mg
Purity: >99.00%
Supply Ability: 500mg
Release date: 2024-03-27

581065-97-6, SPDP-PEG4-acidRelated Search:

SPDP-PEG1-COOH SPDP-PEG5-NHS ester SPDP-PEG10-NHS ester SPDP-PEG8-NHS ester SPDP-PEG8-acid SPDP-PEG5-COOH SPDP-PEG3-NHS ester SPDP-PEG6-acid SPDP-PEG2-NHS ester SPDP-PEG3-COOH SPDP-PEG1-NHS ester SPDP SPDP-PEG6-NHS ester Acrylamide SPDP-PEG4-NHS ester SPDP-dPEG(R)12-NHS ester SPDP-PEG11-NHS ester SPDP-PEG11-COOH

SPDP-PEG4-COOH

Opss-peg(4)-cooh

SPDP-PEG4-acid

SDPD-PEG4-COOH

Propanoic acid, 3-[[13-oxo-15-(2-pyridinyldithio)-3,6,9-trioxa-12-azapentadec-1-yl]oxy]-

3-Oxo-1-(pyridin-2-yldisulfaneyl)-7,10,13,16-tetraoxa-4-azanonadecan-19-oic acid

581065-97-6

C19H30N2O7S2

peg