SPDP-PEG4-acid

Product Name: SPDP-PEG4-acid
CAS No.: 581065-97-6
Chemical Name: SPDP-PEG4-acid
Synonyms: SPDP-PEG4-COOH;SDPD-PEG4-COOH;SPDP-PEG4-acid;Opss-peg(4)-cooh;3-Oxo-1-(pyridin-2-yldisulfaneyl)-7,10,13,16-tetraoxa-4-azanonadecan-19-oic acid;Propanoic acid, 3-[[13-oxo-15-(2-pyridinyldithio)-3,6,9-trioxa-12-azapentadec-1-yl]oxy]-
CBNumber: CB03163139
Molecular Formula: C19H30N2O7S2
Formula Weight: 462.5807
MOL File: 581065-97-6.mol

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SPDP-PEG4-acid Property

Boiling point:: 677.3±55.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: 2-8°C, stored under nitrogen
form: Liquid
pka: 4.28±0.10(Predicted)
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-21939
Product name: SPDP-PEG4-acid
Purity: 98%
Packaging: 100mg
Price: $360
Updated: 2021/12/16

BroadPharm

Product number: BP-21939
Product name: SPDP-PEG4-acid
Purity: 98%
Packaging: 500mg
Price: $500
Updated: 2021/12/16

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SPDP-PEG4-acid Chemical Properties,Usage,Production

Description

SPDP-PEG4-acid is a PEG linker containing SPDP crosslinker and carboxylic acid moieties. SPDP is reactive toward thiol groups and contains a cleavable disulfide bond. Its membrane permeability allows for intracellular crosslinking reactions. The terminal caboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic properties of the PEG linkers increase compound solubility in aqueous media.

Uses

SPDP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

SPDP-PEG4-acid Preparation Products And Raw materials

Raw materials

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View Lastest Price from SPDP-PEG4-acid manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: SPDP-PEG4-COOH 581065-97-6
Price: US $0.00/mg
Min. Order: 500mg
Purity: >99.00%
Supply Ability: 500mg
Release date: 2024-03-27

581065-97-6, SPDP-PEG4-acidRelated Search:

SPDP-PEG1-COOH SPDP-PEG5-NHS ester SPDP-PEG10-NHS ester SPDP-PEG8-NHS ester SPDP-PEG8-acid SPDP-PEG5-COOH SPDP-PEG3-NHS ester SPDP-PEG6-acid SPDP-PEG2-NHS ester SPDP-PEG3-COOH SPDP-PEG1-NHS ester SPDP SPDP-PEG6-NHS ester Acrylamide SPDP-PEG4-NHS ester SPDP-dPEG(R)12-NHS ester SPDP-PEG11-NHS ester SPDP-PEG11-COOH

SPDP-PEG4-COOH

Opss-peg(4)-cooh

SPDP-PEG4-acid

SDPD-PEG4-COOH

Propanoic acid, 3-[[13-oxo-15-(2-pyridinyldithio)-3,6,9-trioxa-12-azapentadec-1-yl]oxy]-

3-Oxo-1-(pyridin-2-yldisulfaneyl)-7,10,13,16-tetraoxa-4-azanonadecan-19-oic acid

581065-97-6

C19H30N2O7S2

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