SPDP-PEG8-NHS ester
- Product Name
- SPDP-PEG8-NHS ester
- CAS No.
- 1252257-56-9
- Chemical Name
- SPDP-PEG8-NHS ester
- Synonyms
- SPDP-dPEG;LC-PEG8-SPDP;SDPD-PEG8-NHS;Opss-peg(8)-nhs;SPDP-dPEG®SPDP-PEG8-NHS ester;SPDP-dPEG®SPDP-dPEG? 8-NHS ester;SPDP-dPEG(R)8-NHS ester;SPDP-dPEG??-NHS ester (QBD-10376)
- CBNumber
- CB43163142
- Molecular Formula
- C31H49N3O13S2
- Formula Weight
- 735.86306
- MOL File
- 1252257-56-9.mol
SPDP-PEG8-NHS ester Property
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- form
- solid or viscous liquid
- pka
- 15.01±0.46(Predicted)
N-Bromosuccinimide Price
- Product number
- QBD10376
- Product name
- SPDP-dPEG®8-NHS ester
- Packaging
- 100MG
- Price
- $361
- Updated
- 2025/07/31
- Product number
- QBD10376
- Product name
- SPDP-dPEG®8-NHS ester
- Packaging
- 1000MG
- Price
- $1810
- Updated
- 2025/07/31
- Product number
- O858653
- Product name
- OPSS-PEG(8)-NHS
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 10376
- Product name
- SPDP-dPEG®₈-NHSester
- Packaging
- 100mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- AS107961
- Product name
- SPDP-dPEG(R)8-NHSester
- Purity
- 94%
- Packaging
- 1g
- Price
- $1885
- Updated
- 2021/12/16
SPDP-PEG8-NHS ester Chemical Properties,Usage,Production
Description
SPDP-PEG8-NHS ester is a PEG linker containing an SPDP crosslinker and an NHS ester. The SPDP crosslinker is reactive toward amine and thiol groups and contains a cleavable disulfide bond. This crosslinker is also membrane permeable which allows for intracellular reactions to take place. The NHS ester can react with primary amines to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.
Uses
LC-PEG8-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs)[1].
reaction suitability
reactivity: thiol reactive
reagent type: cross-linking reagent
reactivity: amine reactive
IC 50
Disulfide Cleavable Linker; Cleavable Linker
References
[1] Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54(10):3606-23. DOI:10.1021/jm2002958
SPDP-PEG8-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
SPDP-PEG8-NHS ester Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@medchemexpress.com
- Country
- United States
- ProdList
- 6398
- Advantage
- 58
View Lastest Price from SPDP-PEG8-NHS ester manufacturers
- Product
- SPDP-PEG8-NHS ester 1252257-56-9
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >99.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-27