7-NITROINDOLE-3-CARBOXALDEHYDE
- Product Name
- 7-NITROINDOLE-3-CARBOXALDEHYDE
- CAS No.
- 10553-14-7
- Chemical Name
- 7-NITROINDOLE-3-CARBOXALDEHYDE
- Synonyms
- Zinc02572407;7-NITROINDOLE-3-ALDEHYDE;3-Carboxy-7-nitro-1H-indole;7-NITROINDOLE-3-CARBOXALDEHYDE;7-NITROINDOLE-3-CARBOXYALDEHYDE;7-NITRO-1H-INDOLE-3-CARBALDEHYDE;7-Nitroindole-3-carboxaldehyde 98%;7-Nitro-1H-indole-3-carboxaldehyde;7-Nitroindole-3-carboxaldehyde,97%;(7-nitro-3-indolylidene)methanolate
- CBNumber
- CB4316686
- Molecular Formula
- C9H6N2O3
- Formula Weight
- 190.16
- MOL File
- 10553-14-7.mol
7-NITROINDOLE-3-CARBOXALDEHYDE Property
- Boiling point:
- 441.5±25.0 °C(Predicted)
- Density
- 1.516±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 12.47±0.30(Predicted)
- form
- Solid
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C9H6N2O3/c12-5-6-4-10-9-7(6)2-1-3-8(9)11(13)14/h1-5,10H
- InChIKey
- ADGKBVRTGVODMM-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2[N+]([O-])=O)C(C=O)=C1
- CAS DataBase Reference
- 10553-14-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- N900623
- Product name
- 7-Nitro-1H-indole-3-carbaldehyde
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- N900623
- Product name
- 7-Nitro-1H-indole-3-carbaldehyde
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR1670
- Product name
- 7-Nitro-1H-indole-3-carboxaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- 4H55-1-W9
- Product name
- 7-Nitro-1H-indole-3-carboxaldehyde
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- 071712
- Product name
- 7-Nitroindole-3-carboxyaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $231
- Updated
- 2021/12/16
7-NITROINDOLE-3-CARBOXALDEHYDE Chemical Properties,Usage,Production
Synthesis
6960-42-5
68-12-2
10553-14-7
Phosphorus oxychloride (POCl3, 0.418 mL, 3.13 mmol) was slowly added dropwise to N,N-dimethylformamide (DMF, 2.08 mL) at 0°C and under argon protection. After stirring the reaction mixture for 5 min, a DMF solution of 7-nitroindole (200 mg, 1.25 mmol) was added (at a concentration of 10 mL of DMF per 1 g of indole). Subsequently, the reaction mixture was gradually warmed to room temperature and stirring was continued for 3 hours. After completion of the reaction, 3.8 M aqueous potassium hydroxide solution (3.29 mL, 12.5 mmol) was added to the mixture and stirring was continued for 15 hours. Next, saturated aqueous sodium bicarbonate and ethyl acetate (EtOAc) were added to the reaction system until the mixture became clarified, followed by separation of the organic layer. The aqueous phase was extracted with ethyl acetate and the combined organic layers were washed with brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent ratio hexane/ethyl acetate = 1/5) to afford the target product 7-nitroindole-3-carbaldehyde (228 mg, 1.20 mmol, 96% yield) as a yellow amorphous solid.
References
[1] Chemical and Pharmaceutical Bulletin, 2018, vol. 66, # 8, p. 810 - 817
[2] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 158 - 167
[3] Tetrahedron Letters, 2009, vol. 50, # 1, p. 75 - 76
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 23, p. 7541 - 7551
[5] Journal of Organic Chemistry, 2013, vol. 78, # 6, p. 2362 - 2372
7-NITROINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
7-NITROINDOLE-3-CARBOXALDEHYDE Suppliers
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View Lastest Price from 7-NITROINDOLE-3-CARBOXALDEHYDE manufacturers
- Product
- 7-Nitroindole-3-carboxaldehyde in stock Factory 10553-14-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 largest production capacity Factory
- Release date
- 2019-04-03
- Product
- 7-NITROINDOLE-3-CARBOXALDEHYDE 10553-14-7
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02