6-Azido-L-norleucine HCl
- Product Name
- 6-Azido-L-norleucine HCl
- CAS No.
- 1454334-76-9
- Chemical Name
- 6-Azido-L-norleucine HCl
- Synonyms
- H-Lys(N3)-OH.HCl;6-Azido-L-norleucine HCl;L-Lys(N3)-OH hydrochloride;Nε-Azido-L-Lysine hydrochloride;L-Azidonorleucine hydrochloride;(2S)-2-amino-6-azidohexanoic acid;(S)-2-Amino-6-azidohexanoic acid hydrochloride;(2S)-2-amino-6-azidohexanoic acid hydrochloride;6-Azido-L-norleucine HCl,L-Azidonorleucine hydrochloride
- CBNumber
- CB43170078
- Molecular Formula
- C6H13ClN4O2
- Formula Weight
- 208.64602
- MOL File
- 1454334-76-9.mol
6-Azido-L-norleucine HCl Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to off-white
- Water Solubility
- Soluble to 100 mM in water
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- A3554
- Product name
- L-Azidonorleucine Hydrochloride
- Packaging
- 250MG
- Price
- $190
- Updated
- 2025/07/31
- Product number
- 6585
- Product name
- L-Azidonorleucinehydrochloride
- Packaging
- 10
- Price
- $97
- Updated
- 2021/12/16
- Product number
- HAA1625
- Product name
- H-L-Lys(N3)-OH*HCl
- Packaging
- 500mg
- Price
- $133.65
- Updated
- 2021/12/16
- Product number
- 30456
- Product name
- Nε-Azido-L-Lysinehydrochloride,98-101%(Assaybytitration)
- Purity
- 98-101%(Assaybytitration)
- Packaging
- 250MG
- Price
- $138.32
- Updated
- 2021/12/16
- Product number
- HAA1625
- Product name
- H-L-Lys(N3)-OH*HCl
- Packaging
- 1g
- Price
- $207.9
- Updated
- 2021/12/16
6-Azido-L-norleucine HCl Chemical Properties,Usage,Production
Uses
L-Azidonorleucine hydrochloride, an unnatural amino acid, is A Methionine surrogate. L-Azidonorleucine hydrochloride can be used to label mammalian cell proteins and identify a diverse set of methionyl-tRNA synthetase (MetRS) mutants [1][2]. L-Azidonorleucine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
in vivo
When L-Azidonorleucine (ANL) is administered via the drinking water, an average daily L-Azidonorleucine intake of 0.9 mg/day/g of body weight for 21 d when aiming to label and identify neuronal populations of the brain are recommended. Lower dosages or shorter labeling times might be used for the labeling of other cell types. When L-Azidonorleucine is administered by i.p. injection, the testing different L-Azidonorleucine doses in the range of 4-400 mM are recommended. A 400 mM dosage administered by i.p. (i.p. volume: 10 ml/kg) once per day for 1 week is recommended for labeling some neuronal populations (such as excitatory neurons of the hippocampus). Lower dosages (e.g., 4 mM) can potentially be used for labeling other cell types or when longer labeling periods are desired[2].
storage
Store at -20°C
References
[1] Alborz Mahdavi, et al. Engineered Aminoacyl-tRNA Synthetase for Cell-Selective Analysis of Mammalian Protein Synthesis. J Am Chem Soc. 2016 Apr 6;138(13):4278-81. DOI:10.1021/jacs.5b08980
[2] Beatriz Alvarez-Castelao, et al. Cell-type-specific metabolic labeling, detection and identification of nascent proteomes in vivo. Nat Protoc. 2019 Feb;14(2):556-575. DOI:10.1038/s41596-018-0106-6
6-Azido-L-norleucine HCl Preparation Products And Raw materials
Raw materials
Preparation Products
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