2-(Benzylamino)-1-(4-methoxyphenyl)-propane

Product Name: 2-(Benzylamino)-1-(4-methoxyphenyl)-propane
CAS No.: 43229-65-8
Chemical Name: 2-(Benzylamino)-1-(4-methoxyphenyl)-propane
Synonyms: N-benzyl-1-(4-Methoxyphenyl)propan-2-aMine;256-155-1;Formoterol Amine;Formoterol Impurity 22;P-METHOXYPHENYL-2-BENZYLAMINOPROPANE;N-BENZYL-1-(4-METHOXYPHENYL)PROPANAMINE;1-(4-METHOXYPHENYL)-2-BENZYL PROPYL AMINE;N-benzyl-4-methoxy-α-methylphenethylamine;Para methoxy phenyl 2-benzyl amino propane;1-(4-METHOXYPHENYL)-2-(BENZYLAMINO)PROPANE
CBNumber: CB4320687
Molecular Formula: C17H21NO
Formula Weight: 255.35
MOL File: 43229-65-8.mol

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2-(Benzylamino)-1-(4-methoxyphenyl)-propane Property

Boiling point:: 377.8±22.0 °C(Predicted)
Density: 1.024±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Miscible with methanol, Methylene chloride. Immiscible with water
pka: 9.54±0.19(Predicted)
form: Oil
color: Pale yellow to yellow liquid
InChI: InChI=1S/C17H21NO/c1-14(18-13-16-6-4-3-5-7-16)12-15-8-10-17(19-2)11-9-15/h3-11,14,18H,12-13H2,1-2H3
InChIKey: CVGPWMGXKOKNFD-UHFFFAOYSA-N
SMILES: C(C1=CC=C(OC)C=C1)C(NCC1=CC=CC=C1)C
LogP: 4.8
CAS DataBase Reference: 43229-65-8(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Medical Isotopes, Inc.

Product number: 59708
Product name: 1-(4-Methoxyphenyl)-2-(benzylamino)propane
Packaging: 2.5g
Price: $1250
Updated: 2021/12/16

Crysdot

Product number: CD12072064
Product name: N-Benzyl-1-(4-methoxyphenyl)propan-2-amine
Purity: 95+%
Packaging: 250mg
Price: $74
Updated: 2021/12/16

Crysdot

Product number: CD12072064
Product name: N-Benzyl-1-(4-methoxyphenyl)propan-2-amine
Purity: 95+%
Packaging: 1g
Price: $186
Updated: 2021/12/16

AHH

Product number: MT-17106
Product name: 1-(4-Methoxyphenyl)-2-(benzylamino)propane
Purity: 98%
Packaging: 100g
Price: $536
Updated: 2021/12/16

Crysdot

Product number: CD12072064
Product name: N-Benzyl-1-(4-methoxyphenyl)propan-2-amine
Purity: 95+%
Packaging: 5g
Price: $557
Updated: 2021/12/16

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2-(Benzylamino)-1-(4-methoxyphenyl)-propane Chemical Properties,Usage,Production

Chemical Properties

Pale yellow liquid

Uses

1-(4-Methoxyphenyl)-2-(benzylamino)propane is an intermediate in the synthesis of Formoterol Fumarate (F693401).

Synthesis

122-84-9

100-46-9

43229-65-8

GENERAL METHOD: 1-(4-methoxyphenyl)propan-2-one (8.22 g, 50.0 mmol) and benzylamine (5.35 g, 50.0 mmol) were dissolved in methanol and 5% Pt/C catalyst (0.83 g) was added. The reaction mixture was stirred at 60°C and hydrogenated for 24 hours. Upon completion of the reaction, the catalyst was removed by filtration and the solvent was removed by rotary evaporation to afford the intermediate N-benzyl-1-(4-methoxyphenyl)propan-2-amine in 95% yield. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.25 (ddd, J = 16.5, 11.1, 6.8 Hz, 5H), 7.07 (d, J = 8.5 Hz, 2H), 6.83 (d, J = 8.5 Hz, 2H), 3.86 (d, J = 13.3 Hz, 1H), 3.79 (s, 3H), 3.73 (d, J = 13.3 Hz, 1H), 2.90 (dd, J = 13.0, 6.5 Hz, 1H), 2.71 (dd, J = 13.5, 7.1 Hz, 1H), 2.61 (dd, J = 13.5, 6.4 Hz, 1H), 1.10 (d, J = 6.2 Hz, 3H). lc/ms (ESI m/z): 256.4 ( M + H)+.

References

[1] Tetrahedron Letters, 1997, vol. 38, # 7, p. 1125 - 1128
[2] Organic Process Research and Development, 1998, vol. 2, # 2, p. 96 - 99
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 12, p. 2903 - 2915
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 1, p. 249 - 253
[5] Patent: US2011/313199, 2011, A1. Location in patent: Page/Page column 14

2-(Benzylamino)-1-(4-methoxyphenyl)-propane Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(Benzylamino)-1-(4-methoxyphenyl)-propane Suppliers

Canada 1 China 158 Germany 1 India 12 United Kingdom 5 United States 13 Global 190

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View Lastest Price from 2-(Benzylamino)-1-(4-methoxyphenyl)-propane manufacturers

Career Henan Chemical Co

Product: 1-(4-Methoxyphenyl)-2-benzylaminopropane 43229-65-8
Price: US $20.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2018-07-27

43229-65-8, 2-(Benzylamino)-1-(4-methoxyphenyl)-propaneRelated Search:

Trimethoprim Diethylstilbestrol Benzyl benzoate Phenoxybenzamine hydrochloride Benzyl alcohol 4-Fluorobenzylamine Benzyl bromide Formoterol Fumarate Dihydrate EP Impurity I Formoterol Impurity 13 n-benzyl-m-toluidine N-METHYL-N-BENZYLANILINE N-Phenylbenzylamine 2-PHENYLBENZYLAMINE HYDROCHLORIDE N-Benzyl-N-ethylaniline 1-(4-Methoxyphenyl)-2-benzylaminopropane Methoxy

P-METHOXYPHENYL-2-BENZYLAMINOPROPANE

N-Benzyl-4-methoxy-alpha-methylphenethylamine

1-(4-METHOXYPHENYL)-2-(BENZYLAMINO)PROPANE

4-Methoxy-α-methyl-N-(phenylmethyl)benzeneethanamine

N-Benzyl-N-(4-methoxy-α-methylphenethyl)amine

1-(3-aMino-2-benzylpropyl)-4-Methoxybenzene

N-benzyl-1-(4-Methoxyphenyl)propan-2-aMine

N-BENZYL-1-(4-METHOXYPHENYL)PROPANAMINE

1-(4-Methoxyphenyl)-2-benzylaminopropane.HCl

Para methoxy phenyl 2-benzyl amino propane

Formoterol Impurity 22

1-(4-METHOXYPHENYL)-2-BENZYL AMINO PROPANE ,98%MIN.

N-[BENZYL-N-( 1-METHYL-2-P-METHOXYPHENYLETHYL)]AMINE

256-155-1

Formoterol Amine

Benzeneethanamine, 4-methoxy-α-methyl-N-(phenylmethyl)-

(RS)-1-(3-amino-4-(benzyloxy)phenyl)-2-(benzyl((SR)-1-(4-methoxy phenyl)propan-2-yl)amino)ethan-1-ol half-fumarate

1-(4-METHOXYPHENYL)-2-BENZYL PROPYL AMINE

2-(BENZYLAMINO)-1-(4-METHOXYPHENYL)-PROPANE

N-benzyl-4-methoxy-α-methylphenethylamine

N-benzyl-1-(4-methoxyphenyl)-2-propanamine

4-Methoxy-alpha-methyl-N-(benzyl)-benzeneethanamine

43229-65-8

C17H21NO

(intermediate of formoterol fumarate)

Intermediate