2'-Deoxy-L-thymidine

ChemicalBook > CAS DataBase List > 2'-Deoxy-L-thymidine

2'-Deoxy-L-thymidine

Product Name: 2'-Deoxy-L-thymidine
CAS No.: 3424-98-4
Chemical Name: 2'-Deoxy-L-thymidine
Synonyms: Ldt;L-Dt;Sebivo;NV 02B;Epavudine;Aids112549;elbivudine;Aids-112549;BETA-L-THYMIDINE;L-Deoxythymidine
CBNumber: CB4321891
Molecular Formula: C10H14N2O5
Formula Weight: 242.23
MOL File: 3424-98-4.mol

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2'-Deoxy-L-thymidine Property

Melting point:: 188-190°C
alpha: D20 -20.3° (c = 0.192 in water)
Density: 1.452±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: H2O: soluble10mg/mL (clear solution)
form: powder
pka: 9.55±0.10(Predicted)
color: white to beige
optical activity: [α]/D -15 to -22°, c = 1 in H2O
InChIKey: IQFYYKKMVGJFEH-CSMHCCOUSA-N

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 24/25
WGK Germany: 3
RTECS: UV9048500
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0293
Product name: Telbivudine
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0293
Product name: Telbivudine
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $523
Updated: 2024/03/01

Cayman Chemical

Product number: 21453
Product name: Telbivudine
Packaging: 10mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 21453
Product name: Telbivudine
Packaging: 100mg
Price: $656
Updated: 2024/03/01

Cayman Chemical

Product number: 21453
Product name: Telbivudine
Packaging: 5mg
Price: $57
Updated: 2024/03/01

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2'-Deoxy-L-thymidine Chemical Properties,Usage,Production

Description

Telbivudine is a b-L-thymidine nucleoside analog launched for the once-daily oral treatment of chronic hepatitis B virus (HBV) infection. It is the fourth nucleoside or nucleotide analog to be marketed for this indication. The previous drugs from this class include lamivudine, a deoxythiacytosine analog, adefovir, a nucleotide analog, and entecavir, a guanosine analog. Adefovir, entecavir, and telbivudine are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections. Telbivudine is efficiently phosphorylated by cellular kinases to the active triphosphate derivative, which inhibits HBV DNA polymerase by competing with the natural substrate, thymidine- 5’-triphosphate.

Chemical Properties

2'-Deoxy-L-thymidine is White Solid

Originator

Idenix (US)

Uses

Nucleoside analog; specific inhibitor of hepatitis B virus (HBV) replication. Antiviral.

Uses

Telbivudine(Tyzeka, Sebivo) is an antiviral drug used in the treatment of hepatitis B infection. Clinical trials have shown it to be significantly more effective than lamivudine or adefovir, and less likely to cause resistance. Telbivudine is a synthetic

Definition

ChEBI: A pyrimidine 2'-deoxyribonucleoside that is the L-enantiomer of thymine. A synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase.

brand name

(Novirio).

2'-Deoxy-L-thymidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2'-Deoxy-L-thymidine manufacturers

Hebei Duling International Trade Co. LTD

Product: 2'-Deoxy-L-thymidine 3424-98-4
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2023-04-20

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Telbivudine 3424-98-4
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 99.5%min
Supply Ability: 10kg
Release date: 2021-08-20

Hebei Mojin Biotechnology Co., Ltd

Product: 2'-Deoxy-L-thymidine 3424-98-4
Price: US $20.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000kg
Release date: 2023-08-17

3424-98-4, 2'-Deoxy-L-thymidineRelated Search:

CHLOROPHOSPHONAZO III Thymidine 3'-Azido-3'-deoxy-D-thymidine Clevudine DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* 3'-Deoxy-D-thymidine 3'-AMINO-3'-DEOXY-D-THYMIDINE 2',3'-Didehydro-3'-deoxy-D-thymidine 5'-AZIDO-5'-DEOXY-D-THYMIDINE 3'-Azido-3'-deoxy-D-thymidine5'-monophosphatesodiumsalt 2'-Deoxy-L-thymidine-d3 5-METHYL-1-(β-L-RIBOFURANOSYL)URACIL 3'-Azido-3'-deoxy-D-thymidine-b-D-glucuronidesodiumsalt 3'-Iodo-3'-deoxy-D-thymidine 5'-Amino-5'-deoxy-D-thymidine 2'-Deoxy-L-thymidine Deoxynucleotide Deoxidizer

BETA-L-THYMIDINE

2'-DEOXY-L-THYMIDINE

L-Thymidine(Telbivudine)

1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione

Β-L-2'-DEOXY-THYMIDINE

2'-Deoxy-L-thyMidine(Telbivudine)

Telbivudine(Tyzeka, Sebivo)

1-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-Methyl-

Telbivudine(L-ThyMidine,LDT-600)

1-[(2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-5-Methyl-1,2,3,4-tetrahydropyriMidine-2,4-dione

2,4(1H,3H)-PyriMidinedione,1-(2-deoxy-b-L-erythro-pentofuranosyl)-5-Methyl-

Sebivo

Telbivudine(L-ThyMidine)

Telbivudine, >=98%

1-(2-Deoxy--L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

1-(2-deoxy--L-erythro-pentofuranosyl)thymine

Epavudine

NV 02B

Aids112549

Aids-112549

L-Deoxythymidine

Ldt

L-Dt

Thymine, 1-(2-deoxy-.beta.-L-erythro-pentofuranosyl)-

1-[(2S,4R,5S)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione

2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-L-erythro-pentofuranosyl)-5-methyl-

elbivudine

2'-Deoxy-L-thymidine USP/EP/BP

Telbivudine (Epavudine)

Telbivudine 13C 15N2

Inhibitor,Telbivudine,inhibit,HBV,Hepatitis B virus

1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

2'-Deoxy-L-thymidine

3424-98-4

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