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BETA-ACETYLDIGOXIN

Product Name
BETA-ACETYLDIGOXIN
CAS No.
5355-48-6
Chemical Name
BETA-ACETYLDIGOXIN
Synonyms
Digotab;digoridb;Cardioreg;novodigal;Cor-puren;B-ACETYLDIGOXIN;2-Acetyl Digoxin;β-Acetyl Digoxin;16’-acetyldigoxin;ACETYLDIGOXIN, B-
CBNumber
CB4328012
Molecular Formula
C43H66O15
Formula Weight
822.98
MOL File
5355-48-6.mol
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BETA-ACETYLDIGOXIN Property

Melting point:
271-273°C
alpha 
D20 +30.4° (c = 1.2 in alc)
Boiling point:
681.03°C (rough estimate)
Density 
1.1139 (rough estimate)
refractive index 
1.5940 (estimate)
storage temp. 
-20°C Freezer
solubility 
Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
pka
13.41±0.70(Predicted)
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Safety

RIDADR 
3249
HazardClass 
6.1(a)
PackingGroup 
II
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000642
Product name
β-Acetyldigoxin for peak identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000642
Price
$150
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0000565
Product name
β-Acetyldigoxin
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000565
Price
$220
Updated
2024/03/01
Usbiological
Product number
296661
Product name
b-Acetyl digoxin
Packaging
1mg
Price
$595
Updated
2021/12/16
TRC
Product number
A173665
Product name
β-AcetylDigoxin
Packaging
5mg
Price
$1005
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0000423
Product name
BETA-ACETYL DIGOXIN
Purity
95.00%
Packaging
10MG
Price
$1963.5
Updated
2021/12/16
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BETA-ACETYLDIGOXIN Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Novodigal ,Asta Medica Arzneimittel

Uses

Digoxin derivative, a cardiotonic glycosides

Definition

ChEBI: Acetyldigoxin is a cardenolide glycoside.

Manufacturing Process

Dried crude product of the partial acetylation of digoxin (42 g) prepared from digitalis - is dissolved under reflux in acetone (480 ml) and n-hexane (2400 ml) is added to the solution with stirring. Fine crystals, which begin to separate immediately, are left at room temperature for 5 hours, then they are filtered with suction, washed with n-hexane and dried in vacuum at 40°C, yielding 32 g of crude β-acetyldigoxin (product 1). Product 1 (31 g) is dissolved under reflux in chloroform (500 ml) and toluene (2500 ml) is added thereto with stirring. The crystals, which separate after standing for 6 hours at room temperature, are filtered, washed with toluene and ether and dried in vacuum yielding 29 g of β-acetyldigoxin (product 2). MP: 249°-251°C.
The filtrate, which results from the separation of product 1, is evaparated to dryness in vacuum. The residue, which mainly contains unreacted digoxin, is purified by recrystallization from pyridine/ether/water (3.5:5:40) and repeatedly acetylated. It can then be recycled to produce more β- acetyldigoxin. The filtrate resulting from the separation of product 2 is evaporated to dryness. The resulting residue contains the di- and polyacetyl derivatives of digoxin, which are deacetylated to digoxin in a known manner and later is returned to a further acetylation process and can then be recycled to produce more β-acetyldigoxin. Beta-Acetyldigoxin may be prepared from digoxin, acetic acid and dicyclohexylcarbodiimide using the last one as a condensing agent.

Therapeutic Function

Cardiotonic

BETA-ACETYLDIGOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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BETA-ACETYLDIGOXIN Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
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China
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S.Z. PhyStandard Bio-Tech. Co., Ltd.
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0755-83725681-603
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+86 755 28094224
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China
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ChemStrong Scientific Co.,Ltd
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0755-0755-66853366 13670046396
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0755-28363542
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sales@chem-strong.com
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China
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
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sales@rrkchem.com
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AFINE CHEMICALS LIMITED
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008657185134895
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China
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Dideu Industries Group Limited
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Guangzhou Dreampharm Biotechnology Co., Ltd.
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020-36607679 17825480238
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QQ 3008233717
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China
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Hubei xin bonus chemical co. LTD
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027-59338440
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BOC Sciences
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+1-631-485-4226
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1-631-614-7828
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inquiry@bocsci.com
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United States
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5355-48-6, BETA-ACETYLDIGOXINRelated Search:


  • novodigal
  • ACETYLDIGOXIN, B-
  • BETA-ACETYLDIGOXIN
  • B-ACETYLDIGOXIN
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  • 4’’’-acetyldigoxin
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  • 3β-[[4-O-[4-O-(4-O-Acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-12β,14-dihydroxy-5β-card-20(22)-enolide
  • 3β-[4-O-[4-O-(4-O-Acetyl 2,6-dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyloxy]-12β,14-dihydroxy-5β,14β-carda-20(22)-enolide
  • Card-20(22)-enolide, 3-((o-4-o-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.4)-o-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-
  • Cardioreg
  • Cor-puren
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  • Acetyldigoxin research grade
  • 2-Acetyl Digoxin
  • (3β,5β,12β)-3-[(O-4-O-Αcetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(14)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(14)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
  • Digoxin IMpurity J
  • acetate,beta-digoxi
  • acetyl-digoxin-beta
  • digoridb
  • digoxigenin+zuckerkettewiebeiacetyl-digitoxin-alpha
  • digoxin,4’’’-acetate
  • hexamethyleneimine3,5-dinitrobenzoate
  • Digoxin EP Impurity J
  • Digoxin Impurity 10(Digoxin EP Impurity J)
  • -acetyldigoxin for peak identification CRS
  • -Acetyldigoxin CRS
  • Card-20(22)-enolide, 3-[(O-4-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
  • β-Acetyl Digoxin
  • BETA-ACETYLDIGOXIN USP/EP/BP
  • 3β-[(4-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12β,14-dihydroxy-5β-card-20(22)-enolide (β-acetyldigoxin),
  • D.?(2R)-2-(acetylamino)-3-(acetylsulfanyl)propanoicacid(N,S-diacetyl-l-cysteine).
  • (2R,3S,4S,6S)-6-(((2R,3S,4S,6S)-6-(((2R,3S,4S,6R)-6-(((3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-Dihydroxy-10,13-dimethyl-17-(5-oxo-2,5-dihydrofuran-3-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate (Digoxin Impurity)
  • 5355-48-6
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