BETA-ACETYLDIGOXIN
- Product Name
- BETA-ACETYLDIGOXIN
- CAS No.
- 5355-48-6
- Chemical Name
- BETA-ACETYLDIGOXIN
- Synonyms
- Digotab;digoridb;Cardioreg;novodigal;Cor-puren;B-ACETYLDIGOXIN;2-Acetyl Digoxin;β-Acetyl Digoxin;16’-acetyldigoxin;ACETYLDIGOXIN, B-
- CBNumber
- CB4328012
- Molecular Formula
- C43H66O15
- Formula Weight
- 822.98
- MOL File
- 5355-48-6.mol
BETA-ACETYLDIGOXIN Property
- Melting point:
- 271-273°C
- alpha
- D20 +30.4° (c = 1.2 in alc)
- Boiling point:
- 681.03°C (rough estimate)
- Density
- 1.1139 (rough estimate)
- refractive index
- 1.5940 (estimate)
- storage temp.
- -20°C Freezer
- solubility
- Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
- pka
- 13.41±0.70(Predicted)
Safety
- RIDADR
- 3249
- HazardClass
- 6.1(a)
- PackingGroup
- II
N-Bromosuccinimide Price
- Product number
- Y0000642
- Product name
- β-Acetyldigoxin for peak identification
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000642
- Price
- $150
- Updated
- 2024/03/01
- Product number
- Y0000565
- Product name
- β-Acetyldigoxin
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0000565
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 296661
- Product name
- b-Acetyl digoxin
- Packaging
- 1mg
- Price
- $595
- Updated
- 2021/12/16
- Product number
- A173665
- Product name
- β-AcetylDigoxin
- Packaging
- 5mg
- Price
- $1005
- Updated
- 2021/12/16
- Product number
- SHG0000423
- Product name
- BETA-ACETYL DIGOXIN
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $1963.5
- Updated
- 2021/12/16
BETA-ACETYLDIGOXIN Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Novodigal ,Asta Medica Arzneimittel
Uses
Digoxin derivative, a cardiotonic glycosides
Definition
ChEBI: Acetyldigoxin is a cardenolide glycoside.
Manufacturing Process
Dried crude product of the partial acetylation of digoxin (42 g) prepared from
digitalis - is dissolved under reflux in acetone (480 ml) and n-hexane (2400
ml) is added to the solution with stirring. Fine crystals, which begin to
separate immediately, are left at room temperature for 5 hours, then they are
filtered with suction, washed with n-hexane and dried in vacuum at 40°C,
yielding 32 g of crude β-acetyldigoxin (product 1). Product 1 (31 g) is
dissolved under reflux in chloroform (500 ml) and toluene (2500 ml) is added
thereto with stirring. The crystals, which separate after standing for 6 hours at
room temperature, are filtered, washed with toluene and ether and dried in
vacuum yielding 29 g of β-acetyldigoxin (product 2). MP: 249°-251°C.
The filtrate, which results from the separation of product 1, is evaparated to
dryness in vacuum. The residue, which mainly contains unreacted digoxin, is
purified by recrystallization from pyridine/ether/water (3.5:5:40) and
repeatedly acetylated. It can then be recycled to produce more β-
acetyldigoxin. The filtrate resulting from the separation of product 2 is
evaporated to dryness. The resulting residue contains the di- and polyacetyl
derivatives of digoxin, which are deacetylated to digoxin in a known manner and later is returned to a further acetylation process and can then be recycled
to produce more β-acetyldigoxin.
Beta-Acetyldigoxin may be prepared from digoxin, acetic acid and
dicyclohexylcarbodiimide using the last one as a condensing agent.
Therapeutic Function
Cardiotonic
BETA-ACETYLDIGOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
BETA-ACETYLDIGOXIN Suppliers
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- Germany
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