BETA-ACETYLDIGOXIN

Product Name: BETA-ACETYLDIGOXIN
CAS No.: 5355-48-6
Chemical Name: BETA-ACETYLDIGOXIN
Synonyms: Digotab;digoridb;Cardioreg;novodigal;Cor-puren;B-ACETYLDIGOXIN;2-Acetyl Digoxin;β-Acetyl Digoxin;16’-acetyldigoxin;ACETYLDIGOXIN, B-
CBNumber: CB4328012
Molecular Formula: C43H66O15
Formula Weight: 822.98
MOL File: 5355-48-6.mol

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BETA-ACETYLDIGOXIN Property

Melting point:: 271-273°C
alpha: D20 +30.4° (c = 1.2 in alc)
Boiling point:: 681.03°C (rough estimate)
Density: 1.1139 (rough estimate)
refractive index: 1.5940 (estimate)
storage temp.: -20°C Freezer
solubility: Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
pka: 13.41±0.70(Predicted)

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Safety

RIDADR: 3249
HazardClass: 6.1(a)
PackingGroup: II

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000642
Product name: β-Acetyldigoxin for peak identification
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000642
Price: $150
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0000565
Product name: β-Acetyldigoxin
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000565
Price: $220
Updated: 2024/03/01

Usbiological

Product number: 296661
Product name: b-Acetyl digoxin
Packaging: 1mg
Price: $595
Updated: 2021/12/16

TRC

Product number: A173665
Product name: β-AcetylDigoxin
Packaging: 5mg
Price: $1005
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0000423
Product name: BETA-ACETYL DIGOXIN
Purity: 95.00%
Packaging: 10MG
Price: $1963.5
Updated: 2021/12/16

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BETA-ACETYLDIGOXIN Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Novodigal ,Asta Medica Arzneimittel

Uses

Digoxin derivative, a cardiotonic glycosides

Definition

ChEBI: Acetyldigoxin is a cardenolide glycoside.

Manufacturing Process

Dried crude product of the partial acetylation of digoxin (42 g) prepared from digitalis - is dissolved under reflux in acetone (480 ml) and n-hexane (2400 ml) is added to the solution with stirring. Fine crystals, which begin to separate immediately, are left at room temperature for 5 hours, then they are filtered with suction, washed with n-hexane and dried in vacuum at 40°C, yielding 32 g of crude β-acetyldigoxin (product 1). Product 1 (31 g) is dissolved under reflux in chloroform (500 ml) and toluene (2500 ml) is added thereto with stirring. The crystals, which separate after standing for 6 hours at room temperature, are filtered, washed with toluene and ether and dried in vacuum yielding 29 g of β-acetyldigoxin (product 2). MP: 249°-251°C.
The filtrate, which results from the separation of product 1, is evaparated to dryness in vacuum. The residue, which mainly contains unreacted digoxin, is purified by recrystallization from pyridine/ether/water (3.5:5:40) and repeatedly acetylated. It can then be recycled to produce more β- acetyldigoxin. The filtrate resulting from the separation of product 2 is evaporated to dryness. The resulting residue contains the di- and polyacetyl derivatives of digoxin, which are deacetylated to digoxin in a known manner and later is returned to a further acetylation process and can then be recycled to produce more β-acetyldigoxin. Beta-Acetyldigoxin may be prepared from digoxin, acetic acid and dicyclohexylcarbodiimide using the last one as a condensing agent.

Therapeutic Function

Cardiotonic

BETA-ACETYLDIGOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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BETA-ACETYLDIGOXIN Suppliers

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5355-48-6, BETA-ACETYLDIGOXINRelated Search:

Hexamethyleneimine Metildigoxin DIGITOXIGENIN Ramnodigin DIGOXIN BETA-ACETYLDIGOXIN digoxigenin-mono(digitoxoside) Digoxin, teraacetate DIGOXIGENIN Digitoxin

novodigal

ACETYLDIGOXIN, B-

BETA-ACETYLDIGOXIN

B-ACETYLDIGOXIN

16’-acetyldigoxin

4’’’-acetyldigoxin

Card-20(22)-enolide, 3-[(O-4-O-acetyl-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3beta,5beta,12beta)-

3β-[[4-O-[4-O-(4-O-Acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-12β,14-dihydroxy-5β-card-20(22)-enolide

3β-[4-O-[4-O-(4-O-Acetyl 2,6-dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyloxy]-12β,14-dihydroxy-5β,14β-carda-20(22)-enolide

Card-20(22)-enolide, 3-((o-4-o-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.4)-o-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-

Cardioreg

Cor-puren

Digotab

Acetyldigoxin research grade

2-Acetyl Digoxin

(3β,5β,12β)-3-[(O-4-O-Αcetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(14)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(14)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide

Digoxin IMpurity J

acetate,beta-digoxi

acetyl-digoxin-beta

digoridb

digoxigenin+zuckerkettewiebeiacetyl-digitoxin-alpha

digoxin,4’’’-acetate

hexamethyleneimine3,5-dinitrobenzoate

Digoxin EP Impurity J

Digoxin Impurity 10(Digoxin EP Impurity J)

-acetyldigoxin for peak identification CRS

-Acetyldigoxin CRS

Card-20(22)-enolide, 3-[(O-4-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-

β-Acetyl Digoxin

BETA-ACETYLDIGOXIN USP/EP/BP

3β-[(4-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12β,14-dihydroxy-5β-card-20(22)-enolide (β-acetyldigoxin),

D.?(2R)-2-(acetylamino)-3-(acetylsulfanyl)propanoicacid(N,S-diacetyl-l-cysteine).

(2R,3S,4S,6S)-6-(((2R,3S,4S,6S)-6-(((2R,3S,4S,6R)-6-(((3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-Dihydroxy-10,13-dimethyl-17-(5-oxo-2,5-dihydrofuran-3-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate (Digoxin Impurity)

5355-48-6

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