ChemicalBook > CAS DataBase List > 4-(1-Acetylpiperazin-4-yl)phenol

4-(1-Acetylpiperazin-4-yl)phenol

Product Name
4-(1-Acetylpiperazin-4-yl)phenol
CAS No.
67914-60-7
Chemical Name
4-(1-Acetylpiperazin-4-yl)phenol
Synonyms
1-ACETYL-4-(4-HYDROXYPHENYL)PIPERAZINE;AHPP;keto06;TIMTEC-BB SBB003353;Ketoconazole Impurity;LABOTEST-BB LT00440741;Ketoconazole Impurity 13;Branchedchainofketoconazole;4-(4-Acetylpiperazino)phenol;1-Acetyl-4-(4-hydroxyphenyl)pi
CBNumber
CB4329307
Molecular Formula
C12H16N2O2
Formula Weight
220.27
MOL File
67914-60-7.mol
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4-(1-Acetylpiperazin-4-yl)phenol Property

Melting point:
180-185 °C (lit.)
Boiling point:
361.21°C (rough estimate)
Density 
1.1115 (rough estimate)
vapor pressure 
0Pa at 20℃
refractive index 
1.6000 (estimate)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Powder
pka
12.18±0.30(Predicted)
color 
White to slightly pink or beige
Water Solubility 
4.3 g/L (20 ºC)
BRN 
795777
InChIKey
AGVNLFCRZULMKK-UHFFFAOYSA-N
LogP
0.3
CAS DataBase Reference
67914-60-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36-36/37/39-22
WGK Germany 
3
HS Code 
29214910
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
511943
Product name
1-Acetyl-4-(4-hydroxyphenyl)piperazine
Purity
98%
Packaging
25g
Price
$31.5
Updated
2023/06/20
TCI Chemical
Product number
A1845
Product name
1-Acetyl-4-(4-hydroxyphenyl)piperazine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$22
Updated
2024/03/01
TCI Chemical
Product number
A1845
Product name
1-Acetyl-4-(4-hydroxyphenyl)piperazine
Purity
>98.0%(GC)(T)
Packaging
250g
Price
$122
Updated
2024/03/01
Alfa Aesar
Product number
B22083
Product name
1-Acetyl-4-(4-hydroxyphenyl)piperazine, 98%
Packaging
100g
Price
$81
Updated
2021/12/16
Alfa Aesar
Product number
B22083
Product name
1-Acetyl-4-(4-hydroxyphenyl)piperazine, 98%
Packaging
25g
Price
$26.9
Updated
2021/12/16
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4-(1-Acetylpiperazin-4-yl)phenol Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

1-Acetyl-4-(4-hydroxyphenyl)piperazine may be used in the preparation of 1-acetyl-4-(4-octadecyloxyphenyl)piperazine. It may also be used in the multi-step synthesis of ketoconazole, its 1,2,4-triazole and thiazole analogs.

General Description

1-Acetyl-4-(4-hydroxyphenyl)piperazine (AHPP), a piperazine derivative, is a structural analog of acetaminophen. Its multi-step preparation using bis-(2-chloroethyl)amine hydrochloride and p-aminophenol as starting materials has been reported.2

Flammability and Explosibility

Not classified

4-(1-Acetylpiperazin-4-yl)phenol Preparation Products And Raw materials

Raw materials

1-Acetyl-4-(4-nitrophenyl)piperazine 4-Chloronitrobenzene PIPERAZINE HEXAHYDRATE 1-(4-Nitrophenyl)piperazine

Preparation Products

Itraconazole
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4-(1-Acetylpiperazin-4-yl)phenol Suppliers

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View Lastest Price from 4-(1-Acetylpiperazin-4-yl)phenol manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-(1-Acetylpiperazin-4-yl)phenol 67914-60-7
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-24
Henan Aochuang Chemical Co.,Ltd.
Product
4-(1-Acetylpiperazin-4-yl)phenol 67914-60-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17
Qiuxian Baitai New Material Co., LTD
Product
1- acetyl -4-(4-hydroxyphenyl) piperazine 67914-60-7
Price
US $1.00/g
Min. Order
1KG
Purity
99%
Supply Ability
5ton/Month
Release date
2021-12-21

67914-60-7, 4-(1-Acetylpiperazin-4-yl)phenolRelated Search:

Acetylacetone Phenol Red PIPERACETAZINE (250 MG) Piperazine N-ACETYL-L-TYROSINE ETHYL ESTER Acetyl coenzyme A sodium salt Acetyl chloride 4,4'-Diacetylbiphenyl 4-Cyanophenol Tetraacetylethylenediamine Phenol Ketoconazole Ketoconazole Impurity 2 KetoconazoleN-Oxide 2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YL METHYL)-1,3-DIOXOLANE-4-METHANOL Ketoconazole Impurity 4 cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate rac-trans-Ketoconazole

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