N,N'-BIS-Z-1-GUANYLPYRAZOLE

Product Name: N,N'-BIS-Z-1-GUANYLPYRAZOLE
CAS No.: 152120-55-3
Chemical Name: N,N'-BIS-Z-1-GUANYLPYRAZOLE
Synonyms: Pyrazol(Z)2;PYRAZOLE(Z)2;Pyrazol(Z)2≥ 99% (HPLC);N,N'-Bis-Z-1-Guanylpyrazole;N,N'-Bis-Z-1-Guanylpyrazole;N,N'-Di-Cbz-1H-pyrazole-1-carbo;1-[N,N'-(Di-Cbz)amidino]pyrazole;N,N'-DI-Z-1H-PYRAZOL-1-CARBAMIDINE;N,N'-DI-Z-1H-PYRAZOLE-1-CARBAMIDINE;N,N'-Di-Cbz-pyrazole-1-carboxamidine
CBNumber: CB4334204
Molecular Formula: C20H18N4O4
Formula Weight: 378.39
MOL File: 152120-55-3.mol

More

Less

N,N'-BIS-Z-1-GUANYLPYRAZOLE Property

Melting point:: 90-96 °C
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 6.66±0.46(Predicted)
color: White to Almost white
InChI: InChI=1S/C20H18N4O4/c25-19(27-14-16-8-3-1-4-9-16)22-18(24-13-7-12-21-24)23-20(26)28-15-17-10-5-2-6-11-17/h1-13H,14-15H2,(H,22,23,25,26)
InChIKey: NRBUVVTTYMTSKM-UHFFFAOYSA-N
SMILES: C(/N1N=CC=C1)(\NC(=O)OCC1C=CC=CC=1)=N\C(=O)OCC1C=CC=CC=1

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10-21
HS Code: 29331990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 439428
Product name: N,N′-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine
Purity: 97%
Packaging: 5g
Price: $222
Updated: 2025/07/31

TCI Chemical

Product number: B3605
Product name: N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboxamidine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $53
Updated: 2025/07/31

TCI Chemical

Product number: B3605
Product name: N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboxamidine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $157
Updated: 2025/07/31

TRC

Product number: Z701600
Product name: N,N''-Bis-Z-1-Guanylpyrazole
Packaging: 500mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-W008067
Product name: N,N'-Bis-Z-1-Guanylpyrazole
Packaging: 10g
Price: $68
Updated: 2021/12/16

More

Less

N,N'-BIS-Z-1-GUANYLPYRAZOLE Chemical Properties,Usage,Production

Chemical Properties

Off-white powder

Uses

N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine is used as pharmaceutical intermediate.

Synthesis

152120-62-2

501-53-1

152120-55-3

Step 2 Synthesis of N,N'-bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine: N-(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine (58.62 g, 239 mmol) was dissolved in 600 mL of anhydrous THF, and the reaction mixture was cooled to 0 °C and stirred under nitrogen atmosphere. 60% NaH (28.8 g) was added to the reaction mixture in batches and the reaction temperature was maintained at 0 °C. Subsequently, 60 mL of anhydrous THF solution of benzyl chloroformate (40.9 mL) was added dropwise over 30 minutes. The reaction mixture was continued to be stirred at 0 °C for 2 hours and then brought to room temperature and stirred for 18 hours. The reaction mixture was again cooled to 0 °C and saturated aqueous Na2SO4 solution was slowly added to quench the reaction. The reaction mixture was diluted with EtOAc and filtered through diatomaceous earth. The organic layer was dried with MgSO4, filtered and concentrated under reduced pressure to give a viscous oil. After washing with hexane and drying under reduced pressure, N,N'-bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine was obtained as 67.81 g in 75% yield.

References

[1] Patent: US2008/207655, 2008, A1. Location in patent: Page/Page column 17

N,N'-BIS-Z-1-GUANYLPYRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N,N'-BIS-Z-1-GUANYLPYRAZOLE Suppliers

Americas 1 China 111 Europe 1 Germany 2 India 4 Japan 1 Switzerland 1 United Kingdom 3 United States 20 Global 144

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928 18796809688
Email: zhouyingxiang@highfine.com
Country: China
ProdList: 1356
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

More

Less

View Lastest Price from N,N'-BIS-Z-1-GUANYLPYRAZOLE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: N,N'-BIS-Z-1-GUANYLPYRAZOLE 152120-55-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: N,N"-BIS-Z-1-GUANYLPYRAZOLE 152120-55-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: N,N"-BIS-Z-1-GUANYLPYRAZOLE 152120-55-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

152120-55-3, N,N'-BIS-Z-1-GUANYLPYRAZOLERelated Search:

Aminoguanidine Sulfate N,N'-BIS-BOC-1-GUANYLPYRAZOLE,N,N''-bis-Boc-1-guanylpyrazole [Pyrazole(Boc)] N,N'-BIS-Z-1-GUANYLPYRAZOLE N-Z-1H-PYRAZOLE-1-CARBOXAMIDINE

Benzyl ((((benzyloxy)carbonyl)aMino)(1H-pyrazol-1-yl)Methylene)carbaMate

Pyrazol(Z)2≥ 99% (HPLC)

Pyrazol(Z)2N,N'-Di-Cbz-1H-pyrazole-1-carbaMidine

N,N'-Di-Cbz-1H-pyrazole-1-carboxamidine

-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine

N-[phenylmethoxycarbonylamino(1-pyrazolyl)methylidene]carbamic acid (phenylmethyl) ester

N,N'-DI-Z-1H-PYRAZOLE-1-CARBAMIDINE

N,N-BIS(BENZYLOXYCARBONYL)-1H-PYRAZOLE-1

N,N-Bisbenzyloxycarbonyl-1-guanylpyrazole, N,N-Di-Cbz-1H-pyrazole-1-carboxamidine

Pyrazol(Z)2

PYRAZOLE(Z)2

N,N'-DI-Z-1H-PYRAZOL-1-CARBAMIDINE

N,N-BISBENZYLOXYCARBONYL-1-GUANYLPYRAZOLE

N,N'-Di-Cbz-1H-pyrazole-1-carbamidine

N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboxamidine

N,N'Bis(Bezyloxycarbonyl)1H-pyrazole1carboxaMidine

N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxaM

Pyrazol(Z)2 N,N'-Bis-Z-1-Guanylpyrazole

N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxaMidine, 98+%

N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine N,N'-Di-Cbz-1H-pyrazole-1-carboxamidine

N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboxamidine &gt

benzyl (NZ)-N-[phenylmethoxycarbonylamino(pyrazol-1-yl)methylidene]carbamate

Carbamic acid, N-[[[(phenylmethoxy)carbonyl]amino]-1H-pyrazol-1-ylmethylene]-, phenylmethyl ester

(Z)-Benzyl(1H-pyrazol-1-yl)methylenedicarbamate

1-[N,N'-(Di-Cbz)amidino]pyrazole

1-[N,N'-Bis(carbobenzoxy)amidino]pyrazole

N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboximidamide

N,N'-Di-Cbz-1H-pyrazole-1-carbo

benzyl (NZ)-N-[benzyloxycarbonylamino(pyrazol-1-yl)methylene]carbamate

N,N'-Bis-Z-1-Guanylpyrazole

Pyrazol(Z)2 N,N'-Bis-Z-1-Guanylpyrazole

N,N'-Di-Cbz-pyrazole-1-carboxamidine

N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine

<i>N,N′</i>-Bis(benzyloxycarbonyl)-1<i>H</i>-pyrazole-1-carboxamidine

N,N′-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine, CAS 152120-55-3

N,N'-Bis-Z-1-Guanylpyrazole

152120-55-3

Guanidine Protection/Guanidinylation

Peptide Synthesis

Specialty Synthesis

Guanidine Protection/Guanidinylation

Peptide Synthesis

Specialty Synthesis