ChemicalBook > CAS DataBase List > N,N'-BIS-Z-1-GUANYLPYRAZOLE

N,N'-BIS-Z-1-GUANYLPYRAZOLE

Product Name
N,N'-BIS-Z-1-GUANYLPYRAZOLE
CAS No.
152120-55-3
Chemical Name
N,N'-BIS-Z-1-GUANYLPYRAZOLE
Synonyms
Pyrazol(Z)2;PYRAZOLE(Z)2;Pyrazol(Z)2≥ 99% (HPLC);N,N'-Bis-Z-1-Guanylpyrazole;N,N'-Bis-Z-1-Guanylpyrazole;N,N'-Di-Cbz-1H-pyrazole-1-carbo;1-[N,N'-(Di-Cbz)amidino]pyrazole;N,N'-DI-Z-1H-PYRAZOL-1-CARBAMIDINE;N,N'-DI-Z-1H-PYRAZOLE-1-CARBAMIDINE;N,N'-Di-Cbz-pyrazole-1-carboxamidine
CBNumber
CB4334204
Molecular Formula
C20H18N4O4
Formula Weight
378.39
MOL File
152120-55-3.mol
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N,N'-BIS-Z-1-GUANYLPYRAZOLE Property

Melting point:
90-96 °C
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
6.66±0.46(Predicted)
color 
White to Almost white
InChI
InChI=1S/C20H18N4O4/c25-19(27-14-16-8-3-1-4-9-16)22-18(24-13-7-12-21-24)23-20(26)28-15-17-10-5-2-6-11-17/h1-13H,14-15H2,(H,22,23,25,26)
InChIKey
NRBUVVTTYMTSKM-UHFFFAOYSA-N
SMILES
C(/N1N=CC=C1)(\NC(=O)OCC1C=CC=CC=1)=N\C(=O)OCC1C=CC=CC=1
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
10-21
HS Code 
29331990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
439428
Product name
N,N′-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine
Purity
97%
Packaging
5g
Price
$222
Updated
2025/07/31
TCI Chemical
Product number
B3605
Product name
N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboxamidine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$53
Updated
2025/07/31
TCI Chemical
Product number
B3605
Product name
N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboxamidine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$157
Updated
2025/07/31
TRC
Product number
Z701600
Product name
N,N''-Bis-Z-1-Guanylpyrazole
Packaging
500mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-W008067
Product name
N,N'-Bis-Z-1-Guanylpyrazole
Packaging
10g
Price
$68
Updated
2021/12/16
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N,N'-BIS-Z-1-GUANYLPYRAZOLE Chemical Properties,Usage,Production

Chemical Properties

Off-white powder

Uses

N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine is used as pharmaceutical intermediate.

Synthesis

152120-62-2

501-53-1

152120-55-3

Step 2 Synthesis of N,N'-bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine: N-(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine (58.62 g, 239 mmol) was dissolved in 600 mL of anhydrous THF, and the reaction mixture was cooled to 0 °C and stirred under nitrogen atmosphere. 60% NaH (28.8 g) was added to the reaction mixture in batches and the reaction temperature was maintained at 0 °C. Subsequently, 60 mL of anhydrous THF solution of benzyl chloroformate (40.9 mL) was added dropwise over 30 minutes. The reaction mixture was continued to be stirred at 0 °C for 2 hours and then brought to room temperature and stirred for 18 hours. The reaction mixture was again cooled to 0 °C and saturated aqueous Na2SO4 solution was slowly added to quench the reaction. The reaction mixture was diluted with EtOAc and filtered through diatomaceous earth. The organic layer was dried with MgSO4, filtered and concentrated under reduced pressure to give a viscous oil. After washing with hexane and drying under reduced pressure, N,N'-bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine was obtained as 67.81 g in 75% yield.

References

[1] Patent: US2008/207655, 2008, A1. Location in patent: Page/Page column 17

N,N'-BIS-Z-1-GUANYLPYRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N'-BIS-Z-1-GUANYLPYRAZOLE Suppliers

Americas 1 China 111 Europe 1 Germany 2 India 4 Japan 1 Switzerland 1 United Kingdom 3 United States 20 Global 144
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
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View Lastest Price from N,N'-BIS-Z-1-GUANYLPYRAZOLE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
N,N'-BIS-Z-1-GUANYLPYRAZOLE 152120-55-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
N,N"-BIS-Z-1-GUANYLPYRAZOLE 152120-55-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
N,N"-BIS-Z-1-GUANYLPYRAZOLE 152120-55-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

152120-55-3, N,N'-BIS-Z-1-GUANYLPYRAZOLERelated Search:

Aminoguanidine Sulfate N,N'-BIS-BOC-1-GUANYLPYRAZOLE,N,N''-bis-Boc-1-guanylpyrazole [Pyrazole(Boc)] N,N'-BIS-Z-1-GUANYLPYRAZOLE N-Z-1H-PYRAZOLE-1-CARBOXAMIDINE

  • Benzyl ((((benzyloxy)carbonyl)aMino)(1H-pyrazol-1-yl)Methylene)carbaMate
  • Pyrazol(Z)2≥ 99% (HPLC)
  • Pyrazol(Z)2N,N'-Di-Cbz-1H-pyrazole-1-carbaMidine
  • N,N'-Di-Cbz-1H-pyrazole-1-carboxamidine
  • -Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine
  • N-[phenylmethoxycarbonylamino(1-pyrazolyl)methylidene]carbamic acid (phenylmethyl) ester
  • N,N'-DI-Z-1H-PYRAZOLE-1-CARBAMIDINE
  • N,N-BIS(BENZYLOXYCARBONYL)-1H-PYRAZOLE-1
  • N,N-Bisbenzyloxycarbonyl-1-guanylpyrazole, N,N-Di-Cbz-1H-pyrazole-1-carboxamidine
  • Pyrazol(Z)2
  • PYRAZOLE(Z)2
  • N,N'-DI-Z-1H-PYRAZOL-1-CARBAMIDINE
  • N,N-BISBENZYLOXYCARBONYL-1-GUANYLPYRAZOLE
  • N,N'-Di-Cbz-1H-pyrazole-1-carbamidine
  • N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboxamidine
  • N,N'Bis(Bezyloxycarbonyl)1H-pyrazole1carboxaMidine
  • N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxaM
  • Pyrazol(Z)2 N,N'-Bis-Z-1-Guanylpyrazole
  • N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxaMidine, 98+%
  • N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine N,N'-Di-Cbz-1H-pyrazole-1-carboxamidine
  • N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboxamidine &gt
  • benzyl (NZ)-N-[phenylmethoxycarbonylamino(pyrazol-1-yl)methylidene]carbamate
  • Carbamic acid, N-[[[(phenylmethoxy)carbonyl]amino]-1H-pyrazol-1-ylmethylene]-, phenylmethyl ester
  • (Z)-Benzyl(1H-pyrazol-1-yl)methylenedicarbamate
  • 1-[N,N'-(Di-Cbz)amidino]pyrazole
  • 1-[N,N'-Bis(carbobenzoxy)amidino]pyrazole
  • N,N'-Bis(carbobenzoxy)-1H-pyrazole-1-carboximidamide
  • N,N'-Di-Cbz-1H-pyrazole-1-carbo
  • benzyl (NZ)-N-[benzyloxycarbonylamino(pyrazol-1-yl)methylene]carbamate
  • N,N'-Bis-Z-1-Guanylpyrazole
  • Pyrazol(Z)2 N,N'-Bis-Z-1-Guanylpyrazole
  • N,N'-Di-Cbz-pyrazole-1-carboxamidine
  • N,N'-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine
  • <i>N,N′</i>-Bis(benzyloxycarbonyl)-1<i>H</i>-pyrazole-1-carboxamidine
  • N,N′-Bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine, CAS 152120-55-3
  • N,N'-Bis-Z-1-Guanylpyrazole
  • 152120-55-3
  • Guanidine Protection/Guanidinylation
  • Peptide Synthesis
  • Specialty Synthesis
  • Guanidine Protection/Guanidinylation
  • Peptide Synthesis
  • Specialty Synthesis