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PARP

Description Source Background
Product Name
PARP
Chemical Name
PARP
Synonyms
PARP;PPOL;ARTD1;PARP-1;EC 2.4.2.30;BOVINE PARP;PARP (BOVINE);PARP-1 (HUMAN);PARP-1 (BOVINE);BOVINE PARP ENZYME
CBNumber
CB4335241
Formula Weight
0
MOL File
Mol file
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PARP Property

storage temp. 
−70°C
form 
buffered aqueous glycerol solution
biological source
rabbit
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Safety

Hazard Codes 
B,T,N,Xn
Risk Statements 
20/22-24-37/38-41-51/53-43-36-20/21/22
Safety Statements 
23-24/25-45-36/37/39-26-61-36/37
WGK Germany 
1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB4500488
Product name
Anti-PARP (Cleaved-Gly<SUP>215</SUP>) antibody produced in rabbit
Purity
affinity isolated antibody
Packaging
100 μg
Price
$522
Updated
2025/07/31
Sigma-Aldrich
Product number
P0996
Product name
PARP-1 human
Purity
recombinant, expressed in E. coli
Packaging
1000UNITS
Price
$743
Updated
2025/07/31
Sigma-Aldrich
Product number
SAB4500488
Product name
Anti-PARP (Cleaved-Gly215) antibody produced in rabbit
Purity
affinity isolated antibody
Packaging
100μg
Price
$506
Updated
2024/03/01
Usbiological
Product number
130886
Product name
PARP1
Packaging
100ug
Price
$539
Updated
2021/12/16
Usbiological
Product number
357912
Product name
PARP1
Packaging
48Tests
Price
$588
Updated
2021/12/16
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PARP Chemical Properties,Usage,Production

Uses

PARP-1 is a nuclear enzyme that synthesizes ADP-ribose polymers from NAD+, specifically binds Zn2+ and DNA, and recognizes single-strand breaks in DNA. PARP1 has been used in a study to assess racial and tissue-specific cancer risk associated with polymorphism in the PARP1 gene. It has also been used in a study to investigate inhibitors of PARP-1 for potential cancer treatments.

General Description

Poly(ADP-ribose) polymerase 1 (PARP-1) is associated with the inflammation response during atherosclerosis.

Biochem/physiol Actions

PARP-1 is inactivated by cleavage into a 24kDA and 89kDA fragment by activated caspase-3 or caspase-7. This results in the decreased ability to repair DNA damage and an increase in apoptosis.

Description

PARP1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 354 amino acids (662-1014a.a.) and having a molecular mass of 39.6 kDa. PARP1 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli

Background

PARP1 takes part in the base excision repair pathway, by catalyzing the poly ADP-ribosyl of a restricted number of acceptor proteins involved in chromatin architecture and in DNA metabolism.. PARP1 mediates the poly ADP-ribosy of APLF and CHFR. PARP1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. PARP1 is a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly ADP-ribosyl. PARP1 takes part in the regulation of various significant cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. PARP1 is a site of mutation in Fanconi anemia, and is involved in the pathophysiology of type I diabetes.

PARP Preparation Products And Raw materials

Raw materials

Preparation Products

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PARP Suppliers

China 26 Japan 1 Switzerland 2 United States 9 Global 38
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
Wuhan Chemstan Biotechnology Co., Ltd.
Tel
027-65317797 15926423062
Fax
QQ：422450190
Email
422450190@qq.com
Country
China
ProdList
10308
Advantage
58
Shanghai Huzhen Industrial Co., LTD
Tel
021-60345367 13916550749
Email
sales@shzbio.com
Country
China
ProdList
9965
Advantage
58
Perfect mRNA
Tel
4006682586 15252998975
Email
rd@perfectmRNA.com
Country
China
ProdList
336
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58
Signalway Antibody LLC
Tel
025-58868422
Email
info@sabbiotech.com
Country
China
ProdList
6243
Advantage
58
Beijing Biosynthesis Biotechnology Co Ltd
Tel
400-9019800
Email
sales@bioss.com.cn
Country
China
ProdList
6102
Advantage
58
Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58
Biosharp
Tel
400-600-4213
Email
info@labgic.com
Country
China
ProdList
6191
Advantage
58

PARPRelated Search:

1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Ribose Gasdermin-A HumanKGF-2 phosphodiesterase 4A, cAMP-specific Inorganic pyrophosphate Tyrosine-protein kinase Srms mTNFα Cys-Protein G EEK/FC CHIMERA

  • Anti-Cyclin L2, C-Terminal antibody produced in rabbit
  • Anti-PARP (Cleaved-Gly215) antibody produced in rabbit
  • PARP-1 (BOVINE) AUTOMODIFIED
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  • PARP-1 (BOVINE)
  • PARP-1 (HUMAN)
  • PARP (BOVINE)
  • BOVINE POLY(ADP-RIBOSE) POLYMERASE
  • EC 2.4.2.30
  • POLY(ADP-RIBOSE) POLYMERASE-1
  • POLY(ADP-RIBOSE) SYNTHETASE-1
  • NAD+ ADP-RIBOSYLTRANSFERASE
  • Poly(ADP-ribose) Polymerase human
  • POLY(ADP-RIBOSE) POLYMERASE
  • POLY(ADP-RIBOSE) PROTEIN
  • POLY(ADP-RIBOSE) SYNTHETASE-1 (AUTOMODIFIED)
  • Poly(ADP-ribose) Polymerase Automodified bovine
  • POLY(ADP-RIBOSE) POLYMERASE-1 (AUTOMODIFIED)
  • PARP-1
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  • Human PARP1 Protein, His Tag
  • ARTD1
  • PPOL