N3-PEG5-CH2COOH
- Product Name
- N3-PEG5-CH2COOH
- CAS No.
- 217180-81-9
- Chemical Name
- N3-PEG5-CH2COOH
- Synonyms
- N3-PEG5-CH2COOH;N3-PEG5-CH2CO2H;Azido-PEG5-CH2CO2H;AZIDE-PEG5-CH2COOH;Azido-PEG5-CH2COOH;17-azido-3,6,9,12,15-pentaoxaheptadecanoic acid;2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
- CBNumber
- CB43354351
- Molecular Formula
- C12H23N3O7
- Formula Weight
- 321.33
- MOL File
- 217180-81-9.mol
N3-PEG5-CH2COOH Property
- storage temp.
- -20°C, protect from light
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- BP-23813
- Product name
- Azido-PEG5-CH2CO2H
- Purity
- 98%
- Packaging
- 500mg
- Price
- $380
- Updated
- 2021/12/16
- Product number
- BP-23813
- Product name
- Azido-PEG5-CH2CO2H
- Purity
- 98%
- Packaging
- 1g
- Price
- $570
- Updated
- 2021/12/16
- Product number
- AS103619
- Product name
- N3-PEG5-CH2COOH
- Purity
- 95+%
- Packaging
- 1g
- Price
- $588
- Updated
- 2021/12/16
- Product number
- AC-8206
- Product name
- N3-PEG5-CH2COOH
- Purity
- 97%
- Packaging
- 1g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- 437505
- Product name
- N3-PEG5-CH2COOH
- Purity
- min.97%
- Packaging
- 1g
- Price
- $504
- Updated
- 2021/12/16
N3-PEG5-CH2COOH Chemical Properties,Usage,Production
Description
Azido-PEG5-CH2CO2H is a water soluble PEG linker. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide.
Uses
Azido-PEG5-CH2CO2H is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-CH2CO2H is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG5-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
Cleavable Linker; PEGs
References
[1] Yong Zu Kim, et al. Antibody-drug conjugates comprising branched linkers and methods related thereto. WO2017089895A1.
N3-PEG5-CH2COOH Preparation Products And Raw materials
Raw materials
Preparation Products
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