Azido-PEG5-CH2CO2-PFP
- Product Name
- Azido-PEG5-CH2CO2-PFP
- CAS No.
- 2144777-92-2
- Chemical Name
- Azido-PEG5-CH2CO2-PFP
- Synonyms
- N3-PEG5-COOPFP;Azido-PEG5-CH2COO-PFP;Azido-PEG5-CH2CO2-PFP;Perfluorophenyl 17-azido-3,6,9,12,15-pentaox aheptadecanoate
- CBNumber
- CB64849544
- Molecular Formula
- C18H22F5N3O7
- Formula Weight
- 487.38
- MOL File
- 2144777-92-2.mol
N-Bromosuccinimide Price
- Product number
- BP-23815
- Product name
- Azido-PEG5-CH2CO2-PFP
- Purity
- 98%
- Packaging
- 100mg
- Price
- $340
- Updated
- 2021/12/16
Azido-PEG5-CH2CO2-PFP Chemical Properties,Usage,Production
Description
Azido-PEG5-CH2CO2-PFP is a PEG linker that contains an azide and a PFP group with one carbon between PEG arm and PFP ester group. The azide group can undergo copper-catalyzed Click Chemistry reactions to react with alkynes. The PFP group can react with amines to form stable bonds. PFP moieties are also less susceptible to undergo hydrolysis. The hydrophilic PEG spacer increases the water solubility of the compound. Longer PEG chains enhance the water solubility properties of the chain.
Uses
Azido-PEG5-CH2CO2-PFP is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1]. Azido-PEG5-CH2CO2-PFP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs; Alkyl/ether
References
[1] Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. DOI:10.1016/j.bmc.2019.115228
Azido-PEG5-CH2CO2-PFP Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Azido-PEG5-CH2CO2-PFP manufacturers
- Product
- Azido-PEG5-CH2COO-PFP 2144777-92-2
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >98.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-23