2,4-Difluoro-3-iodoaniline
- Product Name
- 2,4-Difluoro-3-iodoaniline
- CAS No.
- 1437316-91-0
- Chemical Name
- 2,4-Difluoro-3-iodoaniline
- Synonyms
- HE-CHEMICAL 0400806;2,4-Difluoro-3-iodoaniline;2, 6-dichloro-3-bromoaniline;Benzenamine, 2,4-difluoro-3-iodo-;2,4-difluoro-3-iodoaniline - [AC77843]
- CBNumber
- CB43367577
- Molecular Formula
- C6H4F2IN
- Formula Weight
- 255
- MOL File
- 1437316-91-0.mol
2,4-Difluoro-3-iodoaniline Property
- Boiling point:
- 266.7±40.0 °C(Predicted)
- Density
- 2.086±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, protect from light
- pka
- 2.30±0.10(Predicted)
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D451708
- Product name
- 2,4-Difluoro-3-iodoaniline
- Packaging
- 1g
- Price
- $340
- Updated
- 2021/12/16
- Product number
- 1804EB
- Product name
- 2,4-Difluoro-3-iodoaniline
- Packaging
- 1g
- Price
- $870
- Updated
- 2021/12/16
- Product number
- AK362272
- Product name
- 2,4-Difluoro-3-iodoaniline
- Purity
- 97%
- Packaging
- 1g
- Price
- $91
- Updated
- 2021/12/16
- Product number
- A337360
- Product name
- 2,4-Difluoro-3-iodoaniline
- Purity
- 97%
- Packaging
- 5g
- Price
- $273
- Updated
- 2021/12/16
- Product number
- A337360
- Product name
- 2,4-Difluoro-3-iodoaniline
- Purity
- 97%
- Packaging
- 250mg
- Price
- $35
- Updated
- 2021/12/16
2,4-Difluoro-3-iodoaniline Chemical Properties,Usage,Production
Uses
2,?4-?Difluoro-?3-?iodoaniline is used in the synthetic preparation of purine derivatives that are protein kinase modulators useful in treatment and prevention of protein kinase-mediated diseases.
Synthesis
1145881-54-4
1437316-91-0
General procedure for the synthesis of 2,4-difluoro-3-iodoaniline from 1,3-difluoro-2-iodo-4-nitrobenzene: To a solution of concentrated hydrochloric acid (4 mL) of 1,3-difluoro-2-iodo-4-nitrobenzene (1.14 g, 4 mmol) was added anhydrous stannous chloride (2.71 g, 12 mmol), and the reaction mixture was heated to 50°C and kept for 1 hour. After completion of the reaction, the mixture was diluted with water, neutralized with 5% aqueous sodium hydroxide solution to pH=9, and then extracted with dichloromethane. The organic phase was washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product 2,4-difluoro-3-iodoaniline (0.93 g, 91% yield).1H NMR (CDCl3): δ 6.70-6.93 (2H, m), 6.65 (2H, br).
References
[1] Patent: WO2013/71865, 2013, A1. Location in patent: Page/Page column 57
[2] Patent: CN103102349, 2017, B. Location in patent: Paragraph 0501-0503
2,4-Difluoro-3-iodoaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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