Uses
ChemicalBook > CAS DataBase List > (1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOL

(1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOL

Uses
Product Name
(1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOL
CAS No.
133082-13-0
Chemical Name
(1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOL
Synonyms
(1S)-1-(2-ChL;(S)-1-(2-chlorophenyl)ethane-1,2-diol;(S)-2-(2-CHLOROPHENYL)ETHANE-1,2-DIOL;(1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOL;(1S)-1-(2-Chlorophenyl)-1,2-ethanediol;(1S)-1-(2-Chlorophenyl)ethane-1,2-diol l;(S)-(+)-1-(2-CHLOROPHENYL)-1 2- &;(S)-(+)-1-(2-CHLOROPHENYL)-1,2-ETHANEDIOL;1,2-Ethanediol, 1-(2-chlorophenyl)-, (1S)-;(1S)-1-(2-Chlorophenyl)ethane-1,2-diol,95%
CBNumber
CB4341367
Molecular Formula
C8H9ClO2
Formula Weight
172.61
MOL File
133082-13-0.mol
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(1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOL Property

Melting point:
68-75 °C(lit.)
Boiling point:
293 °C(lit.)
Density 
1.1910 (rough estimate)
refractive index 
1.5530 (estimate)
Flash point:
108 °C
storage temp. 
Sealed in dry,Room Temperature
pka
13.24±0.20(Predicted)
optical activity
[α]20/D +70°, c = 0.2 in chloroform
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26
WGK Germany 
3
HS Code 
2906290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
494194
Product name
(S)-(+)-1-(2-Chlorophenyl)-1,2-ethanediol
Purity
96%
Packaging
1g
Price
$49.9
Updated
2023/06/20
TRC
Product number
C596848
Product name
(S)-(+)-1-(2-Chlorophenyl)-1,2-ethanediol
Packaging
50mg
Price
$60
Updated
2021/12/16
TRC
Product number
C596848
Product name
(S)-(+)-1-(2-Chlorophenyl)-1,2-ethanediol
Packaging
100mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC149258
Product name
(1S)-1-(2-Chlorophenyl)ethane-1,2-diol
Packaging
250mg
Price
$65
Updated
2021/12/16
AK Scientific
Product number
X3149
Product name
(1S)-1-(2-Chlorophenyl)ethane-1,2-diol
Packaging
1g
Price
$107
Updated
2021/12/16
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(1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOL Chemical Properties,Usage,Production

Uses

o-Chlorophenyl glycol is an organic intermediate that can be obtained by oxidizing 2-chlorostyrene with hydrogen peroxide in the presence of a Cr-Anderson type polyacid modified by the catalyst (S)-1-(2-hydroxy-1-phenylethyl)thiourea.

Chemical Properties

white to beige crystals and / or chunks

Synthesis

34966-49-9

32345-65-6

General procedure for the synthesis of (R)-1-(2-chlorophenyl)-1,2-ethanediol from methyl 2-(2-chlorophenyl)-2-oxoacetate: In an inert atmosphere glove box, the substrate methyl 2-(2-chlorophenyl)-2-oxoacetate (0.5 mmol), base (0.05 mmol), Ru-MACHO catalyst (5 μmol) and methanol (0.5 mL). The glass reactor was sealed and transferred to an autoclave, followed by replacing the air in the kettle with hydrogen three times. The reaction was carried out at 25°C or 80°C with constant stirring for 12-24 h under 10-50 bar hydrogen pressure. Upon completion of the reaction, the autoclave was cooled to room temperature. The residual hydrogen was slowly released in a fume hood and the reaction mixture was transferred to a conical flask containing deionized water (2 mL) and extracted with ethyl acetate (3 x 5 mL). The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford the pure target product (R)-1-(2-chlorophenyl)-1,2-ethanediol.

References

[1] Synlett, 2016, vol. 27, # 11, p. 1748 - 1752
[2] Green Chemistry, 2012, vol. 14, # 5, p. 1372 - 1375

(1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOL Suppliers

Belgium 1 China 60 Germany 1 India 1 Japan 1 Switzerland 1 United Kingdom 1 United States 7 Global 73
Acros Organics
Tel
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Fax
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Email
info@acros.com
Country
Belgium
ProdList
6772
Advantage
81
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View Lastest Price from (1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
(1S)-1-(2-Chlorophenyl)-1,2-ethanediol 133082-13-0
Price
US $1.10-9.90/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-08-18
Career Henan Chemical Co
Product
(1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOL 133082-13-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-01

133082-13-0, (1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOLRelated Search:

1-(4-chlorophenyl)ethane-1,2-diol 1,2-Diphenyl-1,2-bis(4-chlorophenyl)ethane-1,2-diol 1,1,2,2-Tetra(4-chlorophenyl)ethane-1,2-diol,1,1,2,2-Tetrakis(4-chlorophenyl)ethane-1,2-diol 4-CHLORO-2-[2-(2,4-DICHLORO-PHENYL)-[1,3]DIOXOLAN-2-YLMETHOXY]-BENZOTHIAZOLE 2,2'-DICHLOROBENZILIC ACID [2-(2,4-DICHLOROPHENYL)-[1,3]DIOXOLAN-2-YL]METHANOL Losigamone cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate (1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOL (S)-2-HYDROXY-2-METHYL(2-CHLOROBENZENE)ACETIC ACID (S)-2-Chloromandelic acid

  • (S)-2-(2-CHLOROPHENYL)ETHANE-1,2-DIOL
  • (S)-(+)-1-(2-CHLOROPHENYL)-1,2-ETHANEDIOL
  • (1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOL
  • (S)-(+)-1-(2-CHLOROPHENYL)-1 2- &
  • (1S)-1-(2-CHLOROPHENYL)ETHANE-1,2-DIOL 95%
  • (1S)-1-(2-Chlorophenyl)ethane-1,2-diol,95%
  • (1S)-1-(2-Chlorophenyl)-1,2-ethanediol
  • (1S)-1-(2-Chlorophenyl)ethane-1,2-diol l
  • (1S)-1-(2-ChL
  • 1,2-Ethanediol, 1-(2-chlorophenyl)-, (1S)-
  • (S)-1-(2-chlorophenyl)ethane-1,2-diol
  • (<i>S</i>)-(+)-1-(2-Chlorophenyl)-1,2-ethanediol
  • 133082-13-0
  • C8H9ClO2
  • ClC6H4CHOHCH2OH
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Organic Building Blocks
  • Polyols
  • Chiral Building Blocks
  • Organic Building Blocks
  • Polyols