6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid

Product Name: 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid
CAS No.: 189005-44-5
Chemical Name: 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid
Synonyms: Zolpidem Acid Impurity;Zolpidem Acid Impurity 2;Zolpidem Acid Impurity 1;Zolpidem Related Compound 5;6-Methyl-2-(4-Methylphenyl)Imi;e[1,2-a]-pyridine-3-acetic Acid;2-[6-Methyl-2-(4-methylphenyl)imida;6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]-;6-METHYL-2-(4-METHYLPHENYL)- IMIDAZO{1,2-A}PYRIDINE-3-;(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETIC ACID
CBNumber: CB4342445
Molecular Formula: C17H16N2O2
Formula Weight: 280.32
MOL File: 189005-44-5.mol

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6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid Property

Melting point:: 243-245°C
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form: solid
pka: 2.87±0.10(Predicted)
color: Yellow
CAS DataBase Reference: 189005-44-5(CAS DataBase Reference)

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: M325903
Product name: ZolpidemAcid
Packaging: 2g
Price: $235
Updated: 2021/12/16

TRC

Product number: M325903
Product name: ZolpidemAcid
Packaging: 25g
Price: $1210
Updated: 2021/12/16

AK Scientific

Product number: J10667
Product name: ZolpidemRelatedCompound5
Packaging: 5mg
Price: $19
Updated: 2021/12/16

AK Scientific

Product number: J10667
Product name: ZolpidemRelatedCompound5
Packaging: 25mg
Price: $38
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IM46256
Product name: 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid
Packaging: 1g
Price: $60
Updated: 2021/12/16

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6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Beige Solid

Uses

An intermediate in the synthesis of Zolpidem.

Synthesis

82626-48-0

189005-44-5

Example 1a Synthesis of 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetic acid: zolpidem (8.0 g, 26.0 mmol) was dissolved in 6N hydrochloric acid (80 mL) at 0°C and protected by argon with magnetic stirring. The reaction mixture was heated to reflux for 18 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and the pH was adjusted to 6.5 by slowly adding 20% sodium hydroxide solution.The precipitated white solid was collected by vacuum filtration to afford the target product, 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetic acid (6.9 g, 94% yield), as a white solid.1H NMR (DMSO-d6) δ 2.30 ( s, 3H), 2.35 (s, 3H), 3.94 (s, 2H), 7.10 (d, J = 9.1 Hz, 1H), 7.25 (d, J = 7.8 Hz, 2H), 7.48 (d, J = 9.1 Hz, 1H), 7.72 (d, J = 7.8 Hz, 2H), 8.18 (s, 1H).13C NMR (100 MHz, DMSO-d6) δ 18.4, 21.4, 30.8, 114.8, 116.6, 121.6, 122.9, 127.9, 128.2, 129.8, 132.4, 137.3, 143.0, 143.5, 171.8.

References

[1] Patent: WO2005/44818, 2005, A2. Location in patent: Page/Page column 18

6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid Suppliers

Canada 1 China 136 Germany 1 India 13 United Kingdom 5 United States 26 Global 182

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View Lastest Price from 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid 189005-44-5
Price: US $1.00/kg
Min. Order: 0.10000000kg
Purity: 99%
Supply Ability: 200KG
Release date: 2024-10-18

Dingwang Technology (Wuhan) Co., Ltd.

Product: Zolpidic Acid 189005-44-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 TONS
Release date: 2022-11-08

Career Henan Chemical Co

Product: 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid 189005-44-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

189005-44-5, 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acidRelated Search:

6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine Triphenyltin acetate 1-Methylimidazole 2,6-Lutidine 4-Methylpyridine Pyridine 2,4,6-Collidine Ethyl 2-(Chlorosulfonyl)acetate Imidazole Azamethiphos Bensulfuron methyl Kresoxim-methyl Methyl 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetate Tolyloyl propionamide Thiophanate-methyl 6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide Methyl Zolpidem tartrate Impurity 6

6-METHYL-2-(4-METHYLPHENYL)IMIDAZO[1,2-A]-PYRIDINE-3-ACETIC ACID

6-methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid

(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETIC ACID

zolpidic acid/6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetic acid

6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]-

6-methyl-2-(4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetic acid (Zolpidic acid)

6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-aceticacid(ForZolpidem)

2-(4-Methylphenyl)-6-methylimidazole[1,2-a]-pyridine-3-acetic Acid

6-Methyl-2-(4-Methylphenyl)Imi

6-METHYL-2-(4-METHYLPHENYL)- IMIDAZO{1,2-A}PYRIDINE-3-

6-METHYL-2-(4-METHYLPHENYL)IMIDAZO[1,2-A]-PYRIDINE-3-ACETIC ACID (FOR ZOLPIDEM)

2-(4-Methylphenyl)-6-methylimidazole[1,2-α]-pyridine-3-acetic Acid

Imidazo[1,2-a]pyridine-3-acetic acid, 6-methyl-2-(4-methylphenyl)-

2-(4-Methylphenyl)-6-MethyliMidazole[1,2-a]-pyridine-3-acetic Acid (ZolpideM IMpurity)

2-(4-METHYL PHENYL)6-METHYLIMIDAZO-(1,2-A)PYRIDINE-3-ACETIC ACID

2-(6-Methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)acetic acid

6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acidATE

Zolpidem Acid Impurity 2

Zolpidem Related Compound 5

[2-(4-methylpheny)-6-methyl[1,2-a]imidazopyridine-3- acetic acid

Dasatinib impurity 4/6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetic acid

2-[6-methyl-2-(4-methylphenyl)-3-imidazo[1,2-a]pyridinyl]acetic acid

2-(4-Methylphenyl)-6-methylimidazole[1,2-a]-pyridine-3-acetic acid 98%

Zolpidem Acid Impurity 1

2-[6-Methyl-2-(4-methylphenyl)imida

e[1,2-a]-pyridine-3-acetic Acid

Zolpidem Acid Impurity

2-(4-Methylphenyl)-6*Methyl Imidazol [1,2-a] Pyridine -3-methylene carboxylic acid (Zolpidic Acid)

6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic...

Tianfu Chem 6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid

Zolpidem Tartrate Impurity: 2-(6-Methyl-2-p-tolylimidazo[1,2-a]pyridin-3-yl)acetic acid

189005-44-5

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Heterocyclic Compounds