BEAUVERICIN

Product Name: BEAUVERICIN
CAS No.: 26048-05-5
Chemical Name: BEAUVERICIN
Synonyms: nivea;bovein;bassiana;beauverin;Beauveria;BEAUVERICIN;BEAUVERFICIN;Beauveria sp.;Beauvericin 97%;13C45-Beauvericin
CBNumber: CB4345714
Molecular Formula: C45H57N3O9
Formula Weight: 783.95
MOL File: 26048-05-5.mol

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BEAUVERICIN Property

Melting point:: 93-94℃
Boiling point:: 975.6±65.0 °C(Predicted)
Density: 1.126±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (30 mg/ml)
pka: -1.02±0.70(Predicted)
form: Solid
color: White
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey: GYSCAQFHASJXRS-ABKJGVMTSA-N
SMILES: C(C1C=CC=CC=1)C1C(OC(C(N(C(C(OC(C(C)C)C(=O)N(C)C(CC2C=CC=CC=2)C(=O)OC(C(C)C)C(=O)N1C)=O)CC1C=CC=CC=1)C)=O)C(C)C)=O

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Safety

WGK Germany: 3
HS Code: 29419090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B7510
Product name: Beauvericin
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $234
Updated: 2025/07/31

Sigma-Aldrich

Product number: 37012
Product name: Beauvericin
Purity: VETRANAL?, analytical standard
Packaging: 100μg
Price: $895
Updated: 2022/05/15

Cayman Chemical

Product number: 11426
Product name: Beauvericin
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 11426
Product name: Beauvericin
Purity: ≥95%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 11426
Product name: Beauvericin
Purity: ≥95%
Packaging: 10mg
Price: $261
Updated: 2024/03/01

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BEAUVERICIN Chemical Properties,Usage,Production

Description

Beauvericin (CAS 26048-05-5) induces apoptosis in A549 cancer cells.1 Disrupts mitochondrial volume regulation.2 Antifungal activity acting via inhibition of both multidrug efflux and TORC1 kinase.3 Crosses the blood-brain barrier in mice.4 Inhibits HIV-1 integrase.5

Chemical Properties

White powder

Uses

Beauvericin is a cyclic depsipeptide isolated from several fungal genera, notably Beauveria and Fusarium, first reported in 1969. Beauvericin exhibits broad antifungal, antibacterial, antiprotozoan and insecticidal activities. At the molecular level, beauvericin exhibits ionophoric properties, and inhibits acyl-CoA:cholesterol acyltransferase activity. Beauvericin induces apoptosis by elevating intracellular calcium levels.

Uses

Toxic depsipeptide with antibiotic and insecticidal effects.Beauvericin is a toxic depsipeptide with antibiotic and insecticidal effects.

Definition

ChEBI: A trimeric cyclodepsipeptide composed from alternating methylphenylalanyl and hydroxyvaleryl residues.

in vivo

Beauvericin (5 mg/kg; i.p.; after the first dosing cycle, observe for two days and continue the second dosing cycle) reduces tumor volume and increases necrosis in allogeneic transplant model mice^[3]. Beauvericin (3, 5, 7 mg/kg; i.p.; once a week for three weeks) can significantly inhibit the growth of H22 allogeneic transplant model mice and increase the levels of TNF-α and IL-2 in mice^[5].

Animal Model:	BALB/c mice injected subcutaneously with mouse CT-26 colon cancer cells on the right side^[3]
Dosage:	5 mg/kg
Administration:	ntraperitoneal injection (i.p.)；The drug was administered on the third day after the injection of colon cancer cells and continued once a day for five days, then stopped for two days of observation, and continued on the tenth day after the injection of colon cancer cells, and continued once a day for four days.
Result:	Reduced the average tumor volume by 52.8 % and the average tumor weight by 60 %.

Animal Model:	Human cervical cancer KB-3-1 xenograft mouse model^[3]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection (i.p.)； The drug was administered once a day starting on the fifth day after cervical cancer injection for five days, followed by two days of observation. The drug was administered once a day starting on the twelfth day after cervical cancer cell injection for four days.
Result:	Reduced the average tumor volume by 31.3 % and the average tumor weight by 31.2 %.

IC 50

ACAT

References

[1] CHIEN-LIN LU. Beauvericin-induced cell apoptosis through the mitogen-activated protein kinase pathway in human nonsmall cell lung cancer A549 cells.[J]. Journal of Toxicological Sciences, 2016, 41 3: 429-437. DOI:10.2131/jts.41.429
[2] ANTON A. TONSHIN . The Fusarium mycotoxins enniatins and beauvericin cause mitochondrial dysfunction by affecting the mitochondrial volume regulation, oxidative phosphorylation and ion homeostasis[J]. Toxicology, 2010, 276 1: Pages 49-57. DOI:10.1016/j.tox.2010.07.001
[3] TANVI SHEKHAR-GUTURJA. Dual action antifungal small molecule modulates multidrug efflux and TOR signaling[J]. Nature chemical biology, 2016, 12 10: 867-875. DOI:10.1038/nchembio.2165
[4] LIEN TAEVERNIER . Blood-brain barrier transport kinetics of the cyclic depsipeptide mycotoxins beauvericin and enniatins[J]. Toxicology letters, 2016, 258: Pages 175-184. DOI:10.1016/j.toxlet.2016.06.1741
[5] CHA-GYUN SHIN. Beauvericin and enniatins H, I and MK1688 are new potent inhibitors of human immunodeficiency virus type-1 integrase[J]. Journal of Antibiotics, 2009, 62 12: 687-690. DOI:10.1038/ja.2009.102

BEAUVERICIN Preparation Products And Raw materials

Raw materials

Filler Potassium Phosphate Monobasic

Preparation Products

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BEAUVERICIN Suppliers

Canada 1 China 189 Germany 1 India 1 Switzerland 1 United Kingdom 6 United States 18 USA 1 Global 218

Alabiotech Inc.

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View Lastest Price from BEAUVERICIN manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: BEAUVERICIN 26048-05-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-29

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: BEAUVERICIN 26048-05-5
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-24

Shanghai Biolang Biotechnology Co., Ltd.

Product: BEAUVERICIN 26048-05-5
Price: US $9.90-7.70/g
Min. Order: 10g
Purity: 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets，Customiz
Supply Ability: 1000kgs
Release date: 2022-02-18

26048-05-5, BEAUVERICINRelated Search:

Emamectin Bis(2-dimethylaminoethyl) ether 2-((2-(2-(DIMETHYLAMINO)ETHOXY)ETHYL) METHYLAMINO)ETHANOL, 97 1,5-DIAMINO-3-OXAPENTANE GLYCINE N-PROPYL ESTER HYDROCHLORIDE N,N-Dimethylglycine ethyl ester Propanamide, 2-hydroxy-N,N-dimethyl- (9CI) N-(2-HYDROXYETHYL)LACTAMIDE N,N-DIMETHYL-L-PHENYLALANINE BEAUVERICIN 1,5-BIS(METHYLAMINO)-3-OXAPENTANE, 98 AC-PHE-OET N,N-DIMETHYL-2-METHOXYACETAMIDE AC-PHE-OME ethyl 2-(propylamino)acetate beauvericin synthetase ethyl 2-(butylamino)acetate N,N-DI(2-METHOXY)ETHYLAMMONIUM ACETATE

Beauvericin, froM Beauveria bassiana

CYCLO-[D-ALPHA-HYDROXYISOVALERYL-L-N-METHYLPHENYLALANYL]3

CYCLO(-D-ALPHA-HYDROXYISOVALERYL-N-ME-PHE)3

BEAUVERICIN

cyclo(d-α-hydroxyisovaleryl-l-n-methyl-phe)3

BEAUVERFICIN

beauverin

beauverin bassiaua vuillemin

bovein

Beauvericin 97%

Cyclo[(2R)-2-hydroxy-3-Methylbutanoyl-N-Methyl-L-phenylalanyl-(2R)-2-hydroxy-3-Methylbutanoyl-N-Methyl-L-phenylalanyl-(2R)-2-hydroxy-3-Methylbutanoyl-N-Methyl-L-phenylalanyl]

Cyclo(-D-a-hydroxyisovaleryl-N-Me-Phe)3

Beauvericin, 99%, from Beauveria bassiana

N-Methylcyclo(L-Phe-D-Hmb-N-methyl-L-Phe-D-Hmb-N-methyl-L-Phe-D-Hmb-)

Beauveria

Beauveria Vuillemin

Beauveria Vuillemin sp

nivea

bassiana

Beauveria sp.

Beauveria bassiana (Bals.-Criv.) Vuill.

Beauveria bassiana (Balsamo) Vuillemin

Beauveria bassiana AS 3.4271

Beauveria brongiartii

BEAUVERICIN USP/EP/BP

13C45-Beauvericin

(3S,6R,9S,12R,15S,18R)-3,9,15-Tribenzyl-6,12,18-triisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexaone

(3S,6R,9S,12R,15S,18R)-3,9,15-tribenzyl-4,10,16-trimethyl-6,12,18-tris(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

Beauvericin in dried down

Beauvericin 100 μg/ml Acetonitrile

Beauvericin in Acetonitrile

Beauvericin, 10 mM in DMSO

26048-05-5

63428-80-0

C45H57N3O9

C44H57N3O8

Biochemicals and Reagents

Amino Acids and Peptides

BioChemical

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