ChemicalBook > CAS DataBase List > OLIGOMYCIN C
OLIGOMYCIN C
- Product Name
- OLIGOMYCIN C
- CAS No.
- 11052-72-5
- Chemical Name
- OLIGOMYCIN C
- Synonyms
- OLIGOMYCIN C;Oligmycin C;12-Deoxyoligomycin A;Oligomycin A, 12-deoxy-;OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
- CBNumber
- CB4354053
- Molecular Formula
- C45H74O10
- Formula Weight
- 775.06
- MOL File
- 11052-72-5.mol
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OLIGOMYCIN C Property
- Boiling point:
- 876.2±65.0 °C(Predicted)
- Density
- 1.091 g/cm3
- storage temp.
- −20°C
- solubility
- Soluble in DMSO
- form
- White to off-white powder.
- pka
- 13.49±0.70(Predicted)
- Merck
- 13,6902
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 19162
- Product name
- Oligomycin C
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $364
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19162
- Product name
- Oligomycin C
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $1088
- Updated
- 2024/03/01
TRC
- Product number
- O532985
- Product name
- OligomycinC
- Packaging
- 1mg
- Price
- $325
- Updated
- 2021/12/16
Usbiological
- Product number
- O6154-02
- Product name
- Oligomycin C
- Packaging
- 1mg
- Price
- $523
- Updated
- 2021/12/16
Apolloscientific
- Product number
- BIO1007
- Product name
- Oligomycin C
- Packaging
- 1mg
- Price
- $134
- Updated
- 2021/12/16
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OLIGOMYCIN C Chemical Properties,Usage,Production
Description
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F1FO-ATP synthase. Inhibition of the ATP synthase by oligomycins leads to cell death.
Uses
Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.
Uses
Oligomycin C is an ATP synthetase and RVD inhibitor.
Safety Profile
A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors
IC 50
Macrolide
References
[1]. yang p w, li m g, zhao j y, et al. oligomycins a and c, major secondary metabolites isolated from the newly isolated strain streptomyces diastaticus[j]. folia microbiologica, 2010, 55(1): 10-16.
[2]. marton a, mihalik r, bratincsák a, et al. apoptotic cell death induced by inhibitors of energy conservation[j]. european journal of biochemistry, 1997, 250(2): 467-475.
OLIGOMYCIN C Preparation Products And Raw materials
Raw materials
Preparation Products
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11052-72-5, OLIGOMYCIN CRelated Search:
Lipopolysaccharides
3-Chloro-2-methylpropene
Glutathione
OLIGOMYCIN A
oligomycin D
oligomycin G
OLIGOMYCIN
oligomycin sensitivity-conferring protein
oligomycin E
Oligomycin F
OLIGOMYCIN B,OLIGOMYCIN B, STREPTOMYCES DIASTATOCHROMOGENES,Oligomycin A, 28-oxo- ,Oligomycin B fromStreptomyces diastatochromogenes
44-homooligomycin A
OLIGOMYCIN C
OLIGOMYCIN A,OLIGOMYCIN COMPLEX,OLIGOMYCIN A, STREPTOMYCES DIASTATOCHROMOGENES,OLIGOMYCIN, STREPTOMYCES DIASTATOCHROMOGENES
44-homooligomycin B