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OLIGOMYCIN C

Product Name
OLIGOMYCIN C
CAS No.
11052-72-5
Chemical Name
OLIGOMYCIN C
Synonyms
OLIGOMYCIN C;Oligmycin C;12-Deoxyoligomycin A;Oligomycin A, 12-deoxy-;OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
CBNumber
CB4354053
Molecular Formula
C45H74O10
Formula Weight
775.06
MOL File
11052-72-5.mol
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OLIGOMYCIN C Property

Boiling point:
876.2±65.0 °C(Predicted)
Density 
1.091 g/cm3
storage temp. 
−20°C
solubility 
Soluble in DMSO
form 
White to off-white powder.
pka
13.49±0.70(Predicted)
Merck 
13,6902
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Safety

Hazard Codes 
Xn
Risk Statements 
22
RIDADR 
2811
RTECS 
RK3335000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2941900000
Toxicity
LD50 ipr-mus: 8300 mg/kg JACSAT 80,6092,1958
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19162
Product name
Oligomycin C
Purity
≥95%
Packaging
1mg
Price
$364
Updated
2024/03/01
Cayman Chemical
Product number
19162
Product name
Oligomycin C
Purity
≥95%
Packaging
5mg
Price
$1088
Updated
2024/03/01
Usbiological
Product number
O6154-02
Product name
Oligomycin C
Packaging
1mg
Price
$523
Updated
2021/12/16
TRC
Product number
O532985
Product name
OligomycinC
Packaging
1mg
Price
$325
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003674
Product name
OLIGOMYCIN C
Purity
95.00%
Packaging
1MG
Price
$617.4
Updated
2021/12/16
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OLIGOMYCIN C Chemical Properties,Usage,Production

Description

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F1FO-ATP synthase. Inhibition of the ATP synthase by oligomycins leads to cell death.

Uses

Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.

Uses

Oligomycin C is an ATP synthetase and RVD inhibitor.

Safety Profile

A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors

References

[1]. yang p w, li m g, zhao j y, et al. oligomycins a and c, major secondary metabolites isolated from the newly isolated strain streptomyces diastaticus[j]. folia microbiologica, 2010, 55(1): 10-16.
[2]. marton a, mihalik r, bratincsák a, et al. apoptotic cell death induced by inhibitors of energy conservation[j]. european journal of biochemistry, 1997, 250(2): 467-475.

OLIGOMYCIN C Preparation Products And Raw materials

Raw materials

Preparation Products

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OLIGOMYCIN C Suppliers

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11052-72-5, OLIGOMYCIN CRelated Search:

3-Chloro-2-methylpropene LIPOPOLYSACCHARIDE FROM ESCHERICHIA COLI Glutathione OLIGOMYCIN A oligomycin D oligomycin G OLIGOMYCIN oligomycin sensitivity-conferring protein oligomycin E Oligomycin F OLIGOMYCIN B,OLIGOMYCIN B, STREPTOMYCES DIASTATOCHROMOGENES,Oligomycin A, 28-oxo- ,Oligomycin B fromStreptomyces diastatochromogenes 44-homooligomycin A OLIGOMYCIN C OLIGOMYCIN A,OLIGOMYCIN COMPLEX,OLIGOMYCIN A, STREPTOMYCES DIASTATOCHROMOGENES,OLIGOMYCIN, STREPTOMYCES DIASTATOCHROMOGENES 44-homooligomycin B

  • 12-Deoxyoligomycin A
  • Oligmycin C
  • OLIGOMYCIN C
  • OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES
  • Oligomycin A, 12-deoxy-
  • Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
  • Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione,22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-,(1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
  • 11052-72-5
  • 11053-72-5
  • C45H74O10
  • Antibiotics A to Z
  • Antibiotics N-S
  • BioChemical
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  • Antibiotics N-SAntibiotics
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  • Antineoplastic and Immunosuppressive AntibioticsAntibiotics
  • Chemical Structure Class
  • Inhibits an EnzymeAntibiotics
  • Macrolides
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