OLIGOMYCIN C Property

Boiling point:

876.2±65.0 °C(Predicted)

Density 

1.091 g/cm3

storage temp. 

−20°C

solubility 

Soluble in DMSO

form 

White to off-white powder.

pka

13.49±0.70(Predicted)

Merck 

13,6902

Safety

Hazard Codes 

Xn

Risk Statements 

22

RIDADR 

2811

RTECS 

RK3335000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

2941900000

Toxicity

LD50 ipr-mus: 8300 mg/kg JACSAT 80,6092,1958

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

OLIGOMYCIN C Chemical Properties,Usage,Production

Description

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F₁F_O-ATP synthase. Inhibition of the ATP synthase by oligomycins leads to cell death.

Uses

Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.

Uses

Oligomycin C is an ATP synthetase and RVD inhibitor.

Safety Profile

A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors

References

[1]. yang p w, li m g, zhao j y, et al. oligomycins a and c, major secondary metabolites isolated from the newly isolated strain streptomyces diastaticus[j]. folia microbiologica, 2010, 55(1): 10-16.
[2]. marton a, mihalik r, bratincsák a, et al. apoptotic cell death induced by inhibitors of energy conservation[j]. european journal of biochemistry, 1997, 250(2): 467-475.