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RO 31-8220 METHANESULFONATE

Product Name
RO 31-8220 METHANESULFONATE
CAS No.
125314-64-9
Chemical Name
RO 31-8220 METHANESULFONATE
Synonyms
RO-31-8220;RO 31-8220 MESYLATE;BisindolylMaleiMide IX;Bisindoylmaleimidine IX;RO 31-8220 METHANESULFONATE;Ro 31-8220 methanesulfonate salt;BISINDOLYLMALEIMIDE IX METHANESULFONATE;BISINDOYLMALEIMIDINE IX METHANESULFONATE;Ro 31-8220 mesylate (Bisindolylmaleimide IX);3-[1-3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL) MALEIMIDE
CBNumber
CB4355393
Molecular Formula
C25H23N5O2S
Formula Weight
457.55
MOL File
125314-64-9.mol
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RO 31-8220 METHANESULFONATE Property

Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: 7.3 mg/mL
form 
solid
pka
7.90±0.60(Predicted)
color 
orange to red
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris
Product number
2002
Product name
Ro31-8220mesylate
Purity
≥97%(HPLC)
Packaging
10
Price
$270
Updated
2021/12/16
Usbiological
Product number
256481
Product name
Ro 31-8220 mesylate
Packaging
10mg
Price
$531
Updated
2021/12/16
ApexBio Technology
Product number
B1287
Product name
Ro31-8220
Packaging
10mg
Price
$138
Updated
2021/12/16
ApexBio Technology
Product number
B1287
Product name
Ro31-8220
Packaging
50mg
Price
$399
Updated
2021/12/16
Biorbyt Ltd
Product number
orb181118
Product name
Ro 31-8220 mesylate
Purity
>98%
Packaging
100mg
Price
$615.4
Updated
2021/12/16
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RO 31-8220 METHANESULFONATE Chemical Properties,Usage,Production

Uses

Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.

Definition

ChEBI: Ro 31-8220 is an imidothiocarbamic ester, a member of indoles and a member of maleimides. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor. It is functionally related to a maleimide.

Biological Activity

Protein kinase C inhibitor, with activity at other protein kinases (IC 50 values are 33, 3, 8, 15 and 38 nM for PKC α , MAPKAP-K1b, MSK1, GSK3 β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na + channels in the micromolar range.

in vivo

Ro 31-8220 (6 mg/kg/d, s.c.) is well tolerated, and has half-life of 5.7 hours in mice. Ro 31-8220-treated MLP?/? mice show a dramatic rescue in fractional shortening after treatment for 6 weeks, but the WT mice shows no change[4].

IC 50

PKC-α: 5 nM (IC50); PKC-βII: 14 nM (IC50); PKC-βI: 24 nM (IC50); PKC-ε: 24 nM (IC50); PKC-γ: 27 nM (IC50); Rat Brain PKC: 23 nM (IC50); MAPKAP-K1b: 3 nM (IC50); MSK1: 8 nM (IC50); S6K1: 15 nM (IC50); GSK3β: 38 nM (IC50)

References

[1]. wilkinson se, parker pj, nixon js. isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase c. biochem j, 1993, 294 ( pt 2): 335-337.
[2]. beltman j, mccormick f, cook sj. the selective protein kinase c inhibitor, ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (mkp-1) expression, induces c-jun expression, and activates jun n-terminal kinase. j biol chem, 1996, 271(43): 27018-27024.
[3]. geiselhart l, conti dj, freed bm. ro 31-8220, a novel protein kinase c inhibitor, inhibits early and late t cell activation events. transplantation, 1996, 61(11): 1637-1642.
[4]. standaert ml, bandyopadhyay g, antwi ek, et al. ro 31-8220 activates c-jun n-terminal kinase and glycogen synthase in rat adipocytes and l6 myotubes. comparison to actions of insulin.

RO 31-8220 METHANESULFONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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RO 31-8220 METHANESULFONATE Suppliers

China 78 Germany 2 Switzerland 2 United Kingdom 1 United States 10 Global 93
Shanghai Boyle Chemical Co., Ltd.
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125314-64-9, RO 31-8220 METHANESULFONATERelated Search:

Silver GF109203X RO 31-8220 (BISINDOYLMALEIMIDINE IX) RO-31-8220 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione RO 31-8220 METHANESULFONATE

  • BISINDOLYLMALEIMIDE IX METHANESULFONATE
  • BISINDOYLMALEIMIDINE IX METHANESULFONATE
  • RO-31-8220
  • RO 31-8220 MESYLATE
  • RO 31-8220 METHANESULFONATE
  • 3-[3-[2,5-DIHYDRO-4-(1-METHYL-1H-INDOL-3-YL)-2,5-DIOXO-1H-PYRROL-3-YL]-1H-INDOL-1-YL]PROPYL CARBAMIMIDOTHIOIC ACID ESTER MESYLATE
  • 3-[1-3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL) MALEIMIDE
  • 3-[1-[3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE METHANESULFONATE
  • 2-[1-[3-(AMIDINOTHIO)PROPYL]-1H-INDOL-3-YL]-3-(1-METHYLINDOL-3-YL)-MALEIMIDE METHANESULFONATE
  • BisindolylMaleiMide IX
  • 2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate salt
  • Bisindoylmaleimidine IX
  • Ro 31-8220 methanesulfonate salt
  • 3-[1-[3-(Amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide] meslate
  • Ro 31-8220 mesylate (Bisindolylmaleimide IX)
  • Carbamimidothioic acid, 3-(3-(2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl ester
  • 125314-64-9
  • C25H23N5O2SCH3SO3H
  • Protein Kinase