RO 31-8220 METHANESULFONATE

Product Name: RO 31-8220 METHANESULFONATE
CAS No.: 125314-64-9
Chemical Name: RO 31-8220 METHANESULFONATE
Synonyms: RO-31-8220;RO 31-8220 MESYLATE;BisindolylMaleiMide IX;Bisindoylmaleimidine IX;RO 31-8220 METHANESULFONATE;Ro 31-8220 methanesulfonate salt;BISINDOLYLMALEIMIDE IX METHANESULFONATE;BISINDOYLMALEIMIDINE IX METHANESULFONATE;Ro 31-8220 mesylate (Bisindolylmaleimide IX);3-[1-3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL) MALEIMIDE
CBNumber: CB4355393
Molecular Formula: C25H23N5O2S
Formula Weight: 457.55
MOL File: 125314-64-9.mol

More

Less

RO 31-8220 METHANESULFONATE Property

Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: H₂O: 7.3 mg/mL
form: solid
pka: 7.90±0.60(Predicted)
color: orange to red

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Tocris

Product number: 2002
Product name: Ro31-8220mesylate
Purity: ≥97%(HPLC)
Packaging: 10
Price: $270
Updated: 2021/12/16

Usbiological

Product number: 256481
Product name: Ro 31-8220 mesylate
Packaging: 10mg
Price: $531
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181118
Product name: Ro 31-8220 mesylate
Purity: >98%
Packaging: 100mg
Price: $615.4
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000215
Product name: RO-31-8220
Purity: 95.00%
Packaging: 1MG
Price: $664.82
Updated: 2021/12/16

ApexBio Technology

Product number: B1287
Product name: Ro31-8220
Packaging: 50mg
Price: $399
Updated: 2021/12/16

More

Less

RO 31-8220 METHANESULFONATE Chemical Properties,Usage,Production

Uses

Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.

Definition

ChEBI: Ro 31-8220 is an imidothiocarbamic ester, a member of indoles and a member of maleimides. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor. It is functionally related to a maleimide.

Biological Activity

Protein kinase C inhibitor, with activity at other protein kinases (IC 50 values are 33, 3, 8, 15 and 38 nM for PKC α , MAPKAP-K1b, MSK1, GSK3 β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na + channels in the micromolar range.

References

[1]. wilkinson se, parker pj, nixon js. isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase c. biochem j, 1993, 294 ( pt 2): 335-337.
[2]. beltman j, mccormick f, cook sj. the selective protein kinase c inhibitor, ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (mkp-1) expression, induces c-jun expression, and activates jun n-terminal kinase. j biol chem, 1996, 271(43): 27018-27024.
[3]. geiselhart l, conti dj, freed bm. ro 31-8220, a novel protein kinase c inhibitor, inhibits early and late t cell activation events. transplantation, 1996, 61(11): 1637-1642.
[4]. standaert ml, bandyopadhyay g, antwi ek, et al. ro 31-8220 activates c-jun n-terminal kinase and glycogen synthase in rat adipocytes and l6 myotubes. comparison to actions of insulin.

RO 31-8220 METHANESULFONATE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

RO 31-8220 METHANESULFONATE Suppliers

China 61 Germany 2 Switzerland 2 United Kingdom 1 United States 9 Global 75

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

ChemCell Biomedicine Co.,Ltd.

Tel: 020-13556033878 2965585218 13556033878
Fax: 0086-0757-85406358
Email: chemcell@hotmail.com
Country: China
ProdList: 369
Advantage: 52

SpringPharma Tech Co.,Ltd

Tel: +86-25-68710855, +86-25-68710897
Fax: 025-68710856
Email: sales@springpharma.net
Country: China
ProdList: 1261
Advantage: 62

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9254
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8449
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

125314-64-9, RO 31-8220 METHANESULFONATERelated Search:

Silver GF109203X RO 31-8220 (BISINDOYLMALEIMIDINE IX) RO-31-8220 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione RO 31-8220 METHANESULFONATE

BISINDOLYLMALEIMIDE IX METHANESULFONATE

BISINDOYLMALEIMIDINE IX METHANESULFONATE

RO-31-8220

RO 31-8220 MESYLATE

RO 31-8220 METHANESULFONATE

3-[3-[2,5-DIHYDRO-4-(1-METHYL-1H-INDOL-3-YL)-2,5-DIOXO-1H-PYRROL-3-YL]-1H-INDOL-1-YL]PROPYL CARBAMIMIDOTHIOIC ACID ESTER MESYLATE

3-[1-3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL) MALEIMIDE

3-[1-[3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE METHANESULFONATE

2-[1-[3-(AMIDINOTHIO)PROPYL]-1H-INDOL-3-YL]-3-(1-METHYLINDOL-3-YL)-MALEIMIDE METHANESULFONATE

BisindolylMaleiMide IX

2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate salt

Bisindoylmaleimidine IX

Ro 31-8220 methanesulfonate salt

3-[1-[3-(Amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide] meslate

Ro 31-8220 mesylate (Bisindolylmaleimide IX)

Carbamimidothioic acid, 3-(3-(2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl ester

125314-64-9

C25H23N5O2SCH3SO3H

Protein Kinase