RO 31-8220 METHANESULFONATE

ChemicalBook > CAS DataBase List > RO 31-8220 METHANESULFONATE

RO 31-8220 METHANESULFONATE

Product Name: RO 31-8220 METHANESULFONATE
CAS No.: 125314-64-9
Chemical Name: RO 31-8220 METHANESULFONATE
Synonyms: RO-31-8220;RO 31-8220 MESYLATE;BisindolylMaleiMide IX;Bisindoylmaleimidine IX;RO 31-8220 METHANESULFONATE;Ro 31-8220 methanesulfonate salt;BISINDOLYLMALEIMIDE IX METHANESULFONATE;BISINDOYLMALEIMIDINE IX METHANESULFONATE;Ro 31-8220 mesylate (Bisindolylmaleimide IX);3-[1-3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL) MALEIMIDE
CBNumber: CB4355393
Molecular Formula: C25H23N5O2S
Formula Weight: 457.55
MOL File: 125314-64-9.mol

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RO 31-8220 METHANESULFONATE Property

Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: H₂O: 7.3 mg/mL
form: solid
pka: 7.90±0.60(Predicted)
color: orange to red

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2002
Product name: Ro31-8220mesylate
Purity: ≥97%(HPLC)
Packaging: 10
Price: $270
Updated: 2021/12/16

Usbiological

Product number: 256481
Product name: Ro 31-8220 mesylate
Packaging: 10mg
Price: $531
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181118
Product name: Ro 31-8220 mesylate
Purity: >98%
Packaging: 100mg
Price: $615.4
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000215
Product name: RO-31-8220
Purity: 95.00%
Packaging: 1MG
Price: $664.82
Updated: 2021/12/16

ApexBio Technology

Product number: B1287
Product name: Ro31-8220
Packaging: 50mg
Price: $399
Updated: 2021/12/16

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RO 31-8220 METHANESULFONATE Chemical Properties,Usage,Production

Uses

Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.

Definition

ChEBI: Ro 31-8220 is an imidothiocarbamic ester, a member of indoles and a member of maleimides. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor. It is functionally related to a maleimide.

Biological Activity

Protein kinase C inhibitor, with activity at other protein kinases (IC 50 values are 33, 3, 8, 15 and 38 nM for PKC α , MAPKAP-K1b, MSK1, GSK3 β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na + channels in the micromolar range.

References

[1]. wilkinson se, parker pj, nixon js. isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase c. biochem j, 1993, 294 ( pt 2): 335-337.
[2]. beltman j, mccormick f, cook sj. the selective protein kinase c inhibitor, ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (mkp-1) expression, induces c-jun expression, and activates jun n-terminal kinase. j biol chem, 1996, 271(43): 27018-27024.
[3]. geiselhart l, conti dj, freed bm. ro 31-8220, a novel protein kinase c inhibitor, inhibits early and late t cell activation events. transplantation, 1996, 61(11): 1637-1642.
[4]. standaert ml, bandyopadhyay g, antwi ek, et al. ro 31-8220 activates c-jun n-terminal kinase and glycogen synthase in rat adipocytes and l6 myotubes. comparison to actions of insulin.

RO 31-8220 METHANESULFONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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RO 31-8220 METHANESULFONATE Suppliers

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125314-64-9, RO 31-8220 METHANESULFONATERelated Search:

Silver GF109203X RO 31-8220 (BISINDOYLMALEIMIDINE IX) RO-31-8220 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione RO 31-8220 METHANESULFONATE

BISINDOLYLMALEIMIDE IX METHANESULFONATE

BISINDOYLMALEIMIDINE IX METHANESULFONATE

RO-31-8220

RO 31-8220 MESYLATE

RO 31-8220 METHANESULFONATE

3-[3-[2,5-DIHYDRO-4-(1-METHYL-1H-INDOL-3-YL)-2,5-DIOXO-1H-PYRROL-3-YL]-1H-INDOL-1-YL]PROPYL CARBAMIMIDOTHIOIC ACID ESTER MESYLATE

3-[1-3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL) MALEIMIDE

3-[1-[3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE METHANESULFONATE

2-[1-[3-(AMIDINOTHIO)PROPYL]-1H-INDOL-3-YL]-3-(1-METHYLINDOL-3-YL)-MALEIMIDE METHANESULFONATE

BisindolylMaleiMide IX

2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate salt

Bisindoylmaleimidine IX

Ro 31-8220 methanesulfonate salt

3-[1-[3-(Amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide] meslate

Ro 31-8220 mesylate (Bisindolylmaleimide IX)

Carbamimidothioic acid, 3-(3-(2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl ester

125314-64-9

C25H23N5O2SCH3SO3H

Protein Kinase