RO 31-8220 METHANESULFONATE
- Product Name
- RO 31-8220 METHANESULFONATE
- CAS No.
- 125314-64-9
- Chemical Name
- RO 31-8220 METHANESULFONATE
- Synonyms
- RO-31-8220;RO 31-8220 MESYLATE;BisindolylMaleiMide IX;Bisindoylmaleimidine IX;RO 31-8220 METHANESULFONATE;Ro 31-8220 methanesulfonate salt;BISINDOLYLMALEIMIDE IX METHANESULFONATE;BISINDOYLMALEIMIDINE IX METHANESULFONATE;Ro 31-8220 mesylate (Bisindolylmaleimide IX);3-[1-3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL) MALEIMIDE
- CBNumber
- CB4355393
- Molecular Formula
- C25H23N5O2S
- Formula Weight
- 457.55
- MOL File
- 125314-64-9.mol
RO 31-8220 METHANESULFONATE Property
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- H2O: 7.3 mg/mL
- form
- solid
- pka
- 7.90±0.60(Predicted)
- color
- orange to red
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 2002
- Product name
- Ro31-8220mesylate
- Purity
- ≥97%(HPLC)
- Packaging
- 10
- Price
- $270
- Updated
- 2021/12/16
- Product number
- 256481
- Product name
- Ro 31-8220 mesylate
- Packaging
- 10mg
- Price
- $531
- Updated
- 2021/12/16
- Product number
- orb181118
- Product name
- Ro 31-8220 mesylate
- Purity
- >98%
- Packaging
- 100mg
- Price
- $615.4
- Updated
- 2021/12/16
- Product number
- KIN0000215
- Product name
- RO-31-8220
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $664.82
- Updated
- 2021/12/16
- Product number
- B1287
- Product name
- Ro31-8220
- Packaging
- 50mg
- Price
- $399
- Updated
- 2021/12/16
RO 31-8220 METHANESULFONATE Chemical Properties,Usage,Production
Uses
Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.
Definition
ChEBI: Ro 31-8220 is an imidothiocarbamic ester, a member of indoles and a member of maleimides. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor. It is functionally related to a maleimide.
Biological Activity
Protein kinase C inhibitor, with activity at other protein kinases (IC 50 values are 33, 3, 8, 15 and 38 nM for PKC α , MAPKAP-K1b, MSK1, GSK3 β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na + channels in the micromolar range.
References
[1]. wilkinson se, parker pj, nixon js. isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase c. biochem j, 1993, 294 ( pt 2): 335-337.
[2]. beltman j, mccormick f, cook sj. the selective protein kinase c inhibitor, ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (mkp-1) expression, induces c-jun expression, and activates jun n-terminal kinase. j biol chem, 1996, 271(43): 27018-27024.
[3]. geiselhart l, conti dj, freed bm. ro 31-8220, a novel protein kinase c inhibitor, inhibits early and late t cell activation events. transplantation, 1996, 61(11): 1637-1642.
[4]. standaert ml, bandyopadhyay g, antwi ek, et al. ro 31-8220 activates c-jun n-terminal kinase and glycogen synthase in rat adipocytes and l6 myotubes. comparison to actions of insulin.
RO 31-8220 METHANESULFONATE Preparation Products And Raw materials
Raw materials
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