Description
ChemicalBook > CAS DataBase List > RO-31-8220

RO-31-8220

Description
Product Name
RO-31-8220
CAS No.
138489-18-6
Chemical Name
RO-31-8220
Synonyms
CS-1132;RO-31-8220;Ro31-8220MsOH;Ro 31-8220 Mesylat;Ro 31-8220/Ro318220;RO-31-8220 USP/EP/BP;Ro-31-8220 in solution;BisindolylMaleiMide IX Mesylate;Ro 31-8220 Mesylate, 10 mM in DMSO;BISINDOLYLMALEIMIDE IX, METHANESULFONATE
CBNumber
CB9711637
Molecular Formula
C25H23N5O2S
Formula Weight
457.55
MOL File
138489-18-6.mol
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RO-31-8220 Property

storage temp. 
2-8°C
solubility 
DMSO:52.77(Max Conc. mg/mL);95.31(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);45.15(Max Conc. mM)
DMF:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
Ethanol:2.77(Max Conc. mg/mL);5.0(Max Conc. mM)
form 
Red solid
color 
Red
biological source
synthetic (organic)
Water Solubility 
water: 1mg/mL
DMSO: 100mg/mL
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Safety

HS Code 
2933790090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
557520
Product name
Ro-31-8220 - CAS 138489-18-6 - Calbiochem
Purity
A cell-permeable, reversible, competitive, and selective inhibitor of protein kinase C (PKC; IC?? = 10 nM) over CaM kinase II (IC?? = 17 μM) and protein kinase A (IC?? = 900 nM).
Packaging
500μg
Price
$139
Updated
2025/07/31
Sigma-Aldrich
Product number
R136
Product name
Ro 31-8220 methanesulfonate salt
Purity
solid
Packaging
1MG
Price
$201
Updated
2023/06/20
Sigma-Aldrich
Product number
R136
Product name
Ro 31-8220 methanesulfonate salt
Purity
solid
Packaging
5MG
Price
$631
Updated
2023/06/20
TCI Chemical
Product number
R0257
Product name
Ro 31-8220 Mesylate
Packaging
10MG
Price
$229
Updated
2025/07/31
Cayman Chemical
Product number
13334
Product name
Bisindolylmaleimide IX (mesylate)
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
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RO-31-8220 Chemical Properties,Usage,Production

Description

Ro 31-8220 mesylate is a potent PKC inhibitor, inhibits PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC with IC50 values of 5, 24, 14, 27, 24 and 23 nM, also inhibits MAPKAP -K1b, MSK1, S6K1 and GSK3β with IC50 of 3, 8, 15, 38 nM.

Uses

Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.

General Description

Ro 31-8220 is a bisindolylmaleimide derivative of staurosporine. Ro 31-8220 blocks MAP kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and stimulates Jun N-terminal Kinase (JNK1). It has immunosuppressive properties.

Biochem/physiol Actions

Inhibitor of GRK-5 (G protein-coupled receptor kinase); PKC (protein kinase C); MAPKAP kinase 1β and p70 S6 kinase.

in vivo

Ro 31-8220 (6 mg/kg/d, s.c.) is well tolerated, and has half-life of 5.7 hours in mice. Ro 31-8220-treated MLP?/? mice show a dramatic rescue in fractional shortening after treatment for 6 weeks, but the WT mice shows no change[4].

IC 50

PKC-α: 5 nM (IC50); PKC-βII: 14 nM (IC50); PKC-βI: 24 nM (IC50); PKC-ε: 24 nM (IC50); PKC-γ: 27 nM (IC50); Rat Brain PKC: 23 nM (IC50); MAPKAP-K1b: 3 nM (IC50); MSK1: 8 nM (IC50); S6K1: 15 nM (IC50); GSK3β: 38 nM (IC50)

storage

+4°C

RO-31-8220 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO-31-8220 Suppliers

China 145 Europe 1 India 2 Japan 2 United Kingdom 3 United States 19 Global 172
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Jinan Trio PharmaTech Co., Ltd.
Tel
0531-88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com
Country
China
ProdList
1856
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
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View Lastest Price from RO-31-8220 manufacturers

Career Henan Chemical Co
Product
Bisindolylmaleimide IX mesylate 138489-18-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

138489-18-6, RO-31-8220Related Search:

GO 6976 D-ERYTHRO-SPHINGOSINE GO 6983 Nintedanib Dasatinib ABT 263 Ponatinib Ibrutinib GF109203X GANGLIOSIDE GD1A DISODIUM SALT BISINDOLYLMALEIMIDE VII 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione RO-31-8220 1-METHYLINDOLE-3-ACETAMIDE RO-31-8220,RO 31-8220 METHANESULFONATE,RO 31-8220 MESYLATE 3-Isopropenyl-1-methyl-1H-pyrrole RO 31-8220 (BISINDOYLMALEIMIDINE IX)

  • RO-31-8220
  • Ro 31-8220 Mesylat
  • BISINDOLYLMALEIMIDE IX, METHANESULFONATE
  • 3-[1-[3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE
  • BISINDOLYLMALEIMIDE IX METHANESULPHONATE SALT
  • BisindolylMaleiMide IX Mesylate
  • BisindolylMaleiMide IX . Methansulfonate [Ro 31-8220]
  • Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, methanesulfonate (1:1)
  • Ro31-8220MsOH
  • Ro 31-8220/Ro318220
  • Ro-31-8220 - CAS 138489-18-6 - Calbiochem
  • 3-[3-[2,5-Dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl carbamimidothioic acid ester mesylate
  • RO 31-8220 METHANESULFONATE; BISINDOLYLMALEIMIDE IX MESYLATE;RO318220
  • CS-1132
  • Bisindolylmaleimide IX (Ro 31-8220 Mesylate)
  • RO-31-8220 USP/EP/BP
  • 3-(3-(4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl carbamimidothioate
  • Ro 31-8220 mesylate (Bisindolylmaleimide IX), Protein kinase inhibitor
  • Ro 31-8220 Mesylate, 10 mM in DMSO
  • Ro-31-8220 in solution
  • 138489-18-6
  • C25H23N5O2SCH4O3S
  • C25H23N5O2S
  • C26H27N5O5S2
  • Smad
  • TGF-beta
  • Inhibitors
  • TGF-beta/Smad
  • inhibitor