Description
ChemicalBook > CAS DataBase List > RO-31-8220

RO-31-8220

Description
Product Name
RO-31-8220
CAS No.
138489-18-6
Chemical Name
RO-31-8220
Synonyms
CS-1132;RO-31-8220;Ro31-8220MsOH;Ro 31-8220 Mesylat;Ro 31-8220/Ro318220;RO-31-8220 USP/EP/BP;BisindolylMaleiMide IX Mesylate;BISINDOLYLMALEIMIDE IX, METHANESULFONATE;Ro-31-8220 - CAS 138489-18-6 - Calbiochem;Bisindolylmaleimide IX (Ro 31-8220 Mesylate)
CBNumber
CB9711637
Molecular Formula
C25H23N5O2S
Formula Weight
457.55
MOL File
138489-18-6.mol
More
Less

RO-31-8220 Property

storage temp. 
2-8°C
solubility 
DMSO:52.77(Max Conc. mg/mL);95.31(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);45.15(Max Conc. mM)
DMF:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
Ethanol:2.77(Max Conc. mg/mL);5.0(Max Conc. mM)
form 
Red solid
color 
Red
More
Less

Safety

HS Code 
2933790090
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
557520
Product name
Ro-31-8220 - CAS 138489-18-6 - Calbiochem
Purity
A cell-permeable, reversible, competitive, and selective inhibitor of protein kinase C (PKC; IC?? = 10 nM) over CaM kinase II (IC?? = 17 μM) and protein kinase A (IC?? = 900 nM).
Packaging
500μg
Price
$159
Updated
2024/03/01
Sigma-Aldrich
Product number
R136
Product name
Ro 31-8220 methanesulfonate salt
Purity
solid
Packaging
1MG
Price
$201
Updated
2023/06/20
Sigma-Aldrich
Product number
R136
Product name
Ro 31-8220 methanesulfonate salt
Purity
solid
Packaging
5MG
Price
$631
Updated
2023/06/20
Cayman Chemical
Product number
13334
Product name
Bisindolylmaleimide IX (mesylate)
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
13334
Product name
Bisindolylmaleimide IX (mesylate)
Purity
≥98%
Packaging
5mg
Price
$166
Updated
2024/03/01
More
Less

RO-31-8220 Chemical Properties,Usage,Production

Description

Ro 31-8220 mesylate is a potent PKC inhibitor, inhibits PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC with IC50 values of 5, 24, 14, 27, 24 and 23 nM, also inhibits MAPKAP -K1b, MSK1, S6K1 and GSK3β with IC50 of 3, 8, 15, 38 nM.

Uses

Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.

General Description

Ro 31-8220 is a bisindolylmaleimide derivative of staurosporine. Ro 31-8220 blocks MAP kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and stimulates Jun N-terminal Kinase (JNK1). It has immunosuppressive properties.

Biochem/physiol Actions

Inhibitor of GRK-5 (G protein-coupled receptor kinase); PKC (protein kinase C); MAPKAP kinase 1β and p70 S6 kinase.

storage

+4°C

RO-31-8220 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

RO-31-8220 Suppliers

China 109 Europe 1 India 2 Japan 2 United Kingdom 3 United States 18 Global 135
Discovery Fine Chemicals
Tel
--
Fax
--
Country
Europe
ProdList
1780
Advantage
38
More
Less

View Lastest Price from RO-31-8220 manufacturers

Career Henan Chemical Co
Product
Bisindolylmaleimide IX mesylate 138489-18-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

138489-18-6, RO-31-8220Related Search:

GO 6976 D-ERYTHRO-SPHINGOSINE GO 6983 Nintedanib Dasatinib ABT 263 Ponatinib Ibrutinib GF109203X GANGLIOSIDE GD1A DISODIUM SALT BISINDOLYLMALEIMIDE VII 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione RO-31-8220 1-METHYLINDOLE-3-ACETAMIDE RO-31-8220,RO 31-8220 METHANESULFONATE,RO 31-8220 MESYLATE 3-Isopropenyl-1-methyl-1H-pyrrole RO 31-8220 (BISINDOYLMALEIMIDINE IX)

  • RO-31-8220
  • Ro 31-8220 Mesylat
  • BISINDOLYLMALEIMIDE IX, METHANESULFONATE
  • 3-[1-[3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE
  • BISINDOLYLMALEIMIDE IX METHANESULPHONATE SALT
  • BisindolylMaleiMide IX Mesylate
  • BisindolylMaleiMide IX . Methansulfonate [Ro 31-8220]
  • Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, methanesulfonate (1:1)
  • Ro31-8220MsOH
  • Ro 31-8220/Ro318220
  • Ro-31-8220 - CAS 138489-18-6 - Calbiochem
  • 3-[3-[2,5-Dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl carbamimidothioic acid ester mesylate
  • RO 31-8220 METHANESULFONATE; BISINDOLYLMALEIMIDE IX MESYLATE;RO318220
  • CS-1132
  • Bisindolylmaleimide IX (Ro 31-8220 Mesylate)
  • RO-31-8220 USP/EP/BP
  • 3-(3-(4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl carbamimidothioate
  • 138489-18-6
  • C25H23N5O2SCH4O3S
  • C25H23N5O2S
  • C26H27N5O5S2
  • Smad
  • TGF-beta
  • Inhibitors
  • TGF-beta/Smad
  • inhibitor