ChemicalBook > CAS DataBase List > RO-31-8220
RO-31-8220
Description- Product Name
- RO-31-8220
- CAS No.
- 138489-18-6
- Chemical Name
- RO-31-8220
- Synonyms
- CS-1132;RO-31-8220;Ro31-8220MsOH;Ro 31-8220 Mesylat;Ro 31-8220/Ro318220;RO-31-8220 USP/EP/BP;BisindolylMaleiMide IX Mesylate;BISINDOLYLMALEIMIDE IX, METHANESULFONATE;Ro-31-8220 - CAS 138489-18-6 - Calbiochem;Bisindolylmaleimide IX (Ro 31-8220 Mesylate)
- CBNumber
- CB9711637
- Molecular Formula
- C25H23N5O2S
- Formula Weight
- 457.55
- MOL File
- 138489-18-6.mol
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RO-31-8220 Property
- storage temp.
- 2-8°C
- solubility
- DMSO:52.77(Max Conc. mg/mL);95.31(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);45.15(Max Conc. mM)
DMF:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
Ethanol:2.77(Max Conc. mg/mL);5.0(Max Conc. mM) - form
- Red solid
- color
- Red
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Safety
- HS Code
- 2933790090
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 557520
- Product name
- Ro-31-8220 - CAS 138489-18-6 - Calbiochem
- Purity
- A cell-permeable, reversible, competitive, and selective inhibitor of protein kinase C (PKC; IC?? = 10 nM) over CaM kinase II (IC?? = 17 μM) and protein kinase A (IC?? = 900 nM).
- Packaging
- 500μg
- Price
- $159
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- R136
- Product name
- Ro 31-8220 methanesulfonate salt
- Purity
- solid
- Packaging
- 1MG
- Price
- $201
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- R136
- Product name
- Ro 31-8220 methanesulfonate salt
- Purity
- solid
- Packaging
- 5MG
- Price
- $631
- Updated
- 2023/06/20
Cayman Chemical
- Product number
- 13334
- Product name
- Bisindolylmaleimide IX (mesylate)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13334
- Product name
- Bisindolylmaleimide IX (mesylate)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $166
- Updated
- 2024/03/01
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RO-31-8220 Chemical Properties,Usage,Production
Description
Ro 31-8220 mesylate is a potent PKC inhibitor, inhibits PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC with IC50 values of 5, 24, 14, 27, 24 and 23 nM, also inhibits MAPKAP -K1b, MSK1, S6K1 and GSK3β with IC50 of 3, 8, 15, 38 nM.
Uses
Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.
General Description
Ro 31-8220 is a bisindolylmaleimide derivative of staurosporine. Ro 31-8220 blocks MAP kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and stimulates Jun N-terminal Kinase (JNK1). It has immunosuppressive properties.
Biochem/physiol Actions
Inhibitor of GRK-5 (G protein-coupled receptor kinase); PKC (protein kinase C); MAPKAP kinase 1β and p70 S6 kinase.
storage
+4°C
RO-31-8220 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from RO-31-8220 manufacturers
Career Henan Chemical Co
- Product
- Bisindolylmaleimide IX mesylate 138489-18-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-01
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